Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Alan Schuster"'
Autor:
Yan Song, Zhigang Yu, Allyson Pollack, Jessie Wang, Lois Lee, Alan Schuster, Charles Frost, Frank LaCreta
Publikováno v:
Clinical Pharmacology : Advances and Applications
Charles Frost,1 Yan Song,1 Zhigang Yu,2 Jessie Wang,3 Lois S Lee,4 Alan Schuster,5 Allyson Pollack,1 Frank LaCreta1 1Exploratory Clinical and Translational Research, Bristol-Myers Squibb, Princeton, NJ, USA; 2Medical Sciences, Amgen Asia R&D Center,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c38f8cd79b4d01ebe5d3a95737ecb5a0
http://europepmc.org/articles/PMC5327911
http://europepmc.org/articles/PMC5327911
Publikováno v:
Journal of Chromatography B. 1002:201-209
Sample dilution is one major challenge in dried blood spot (DBS) bioanalysis. To resolve this issue, we applied a no-dilution strategy for DBS analysis by using a calibration curve with very wide linear range. We developed an LC-MS/MS DBS assay with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b62d550e34b435c24fe9a85037e0a88e
https://doi.org/10.1016/j.jchromb.2015.08.029
https://doi.org/10.1016/j.jchromb.2015.08.029
Autor:
Jessie Wang, Clapton Dias, Rebecca A. Boyd, Zhigang Yu, Donglu Zhang, Alan Schuster, Charles Frost, Andrew Shenker, Frank LaCreta, Yan Song, Wonkyung Byon
Publikováno v:
British Journal of Clinical Pharmacology. 79:838-846
Aim Apixaban is an orally active inhibitor of coagulation factor Xa and is eliminated by multiple pathways, including renal and non-renal elimination. Non-renal elimination pathways consist of metabolism by cytochrome P450 (CYP) enzymes, primarily CY
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bf1cb0cff55f2a2a52e6f6bf0147b41
https://doi.org/10.1111/bcp.12541
https://doi.org/10.1111/bcp.12541
Autor:
Yu Chen Barrett, Andrew Shenker, Stuart I. Harris, Alan Schuster, Jessie Wang, Yan Song, Frank LaCreta, Charles Frost
Publikováno v:
Clinical Pharmacokinetics
Background and Objectives The effects of age and sex on apixaban pharmacokinetics and pharmacodynamics were studied. Methods This was an open-label, single-dose, 2 × 2 factorial study. Healthy young (aged 18–40 years) and elderly (aged ≥65 years
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88f381a779ec3cb8c6e7d109ae363671
http://europepmc.org/articles/PMC4449375
http://europepmc.org/articles/PMC4449375
Publikováno v:
Clinical Pharmacology : Advances and Applications
Yimin Cui,1 Yan Song,2 Jessie Wang,2 Zhigang Yu,2 Alan Schuster,2 Yu Chen Barrett,2 Charles Frost21Peking University First Hospital, Beijing, People's Republic of China; 2Bristol-Myers Squibb, Princeton, NJ, USABackground: The pharmacokinetics (PK),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62e4a60c65eccc6384eb409562eb5895
http://europepmc.org/articles/PMC3861362
http://europepmc.org/articles/PMC3861362
Autor:
Zhigang Yu, Yu Chen Barrett, Jessie Wang, Wonkyung Byon, Rebecca A. Boyd, Charles Frost, Alan Schuster, Sunil Nepal, Frank LaCreta, Andrew Shenker, Rogelio Mosqueda-Garcia
Publikováno v:
British Journal of Clinical Pharmacology. 76:776-786
Aim Apixaban is an oral factor Xa inhibitor approved for stroke prevention in atrial fibrillation and thromboprophylaxis in patients who have undergone elective hip or knee replacement surgery and under development for treatment of venous thromboembo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b56acd9cbef0735ab6dc041f083350db
https://doi.org/10.1111/bcp.12106
https://doi.org/10.1111/bcp.12106
Publikováno v:
Journal of Chromatography B. 934:1-7
A liquid chromatography tandem mass spectrometry (LC–MS/MS) method has been developed and validated for a PEGylated adnectin therapeutic protein in cynomolgus monkey plasma. The validated method was performed using protein precipitation coupled wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f5489b360509175b46e54ae322c3f05
https://doi.org/10.1016/j.jchromb.2013.06.027
https://doi.org/10.1016/j.jchromb.2013.06.027
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 70:401-407
To support a first-in-human (FIH) clinical study in healthy volunteers, a human plasma assay, a 20-fold more sensitive method than the validated non-clinical LC–MS/MS assays, was requested. For the clinical assay, a LLOQ of 0.050 ng/mL for Compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cb6bdfa606b851528878a49c986cefa
https://doi.org/10.1016/j.jpba.2012.06.011
https://doi.org/10.1016/j.jpba.2012.06.011
Publikováno v:
Pharmaceutical Research. 23:989-996
The purpose of the study was to investigate the specific mechanism by which elevated gastric pH reduces the absorption of BMS-561389, a factor Xa inhibitor, and to develop a solid formulation strategy to overcome this gastric pH interaction.A dissolu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f47a68ca2c766b3dee45800d63c4c009
https://doi.org/10.1007/s11095-006-9899-z
https://doi.org/10.1007/s11095-006-9899-z
Publikováno v:
Rapid Communications in Mass Spectrometry. 17:1723-1734
Selective, accurate, and reproducible liquid chromatography/tandem mass spectrometry (LC/MS/MS) methods were developed and validated for the determination of mevalonic acid, an intermediate in the biosynthesis of cholesterol and therefore a useful bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e92a66b0cd2fe2176a279fe90ca2692
https://doi.org/10.1002/rcm.1112
https://doi.org/10.1002/rcm.1112