Zobrazeno 1 - 10
of 233
pro vyhledávání: '"Alan S. Wayne"'
Autor:
Anupam Verma, Yueh-Yun Chi, Jemily Malvar, Adam Lamble, Sonali Chaudhury, Archana Agarwal, Hong-Tao Li, Gangning Liang, Roy Leong, Patrick A. Brown, Joel Kaplan, Eric S. Schafer, Tamra Slone, Melinda Pauly, Bill H. Chang, Elliot Stieglitz, Alan S. Wayne, Nobuko Hijiya, Deepa Bhojwani
Publikováno v:
Cancers, Vol 16, Iss 3, p 496 (2024)
Improvements in survival have been made over the past two decades for childhood acute myeloid leukemia (AML), but the approximately 40% of patients who relapse continue to have poor outcomes. A combination of checkpoint-inhibitor nivolumab and azacit
Externí odkaz:
https://doaj.org/article/498c6ca081b64cb09353822d5f07e337
Autor:
Alan S. Wayne, Van Huynh, Nobuko Hijiya, Rayne H. Rouce, Patrick A. Brown, Joerg Krueger, Carrie L. Kitko, Edward Dela Ziga, Michelle L. Hermiston, Michael K. Richards, Andre Baruchel, Petra C. Schuberth, John Rossi, Lang Zhou, Lovely Goyal, Rajul Jain, Remus Vezan, Behzad Kharabi Masouleh, Daniel W. Lee
Publikováno v:
Haematologica, Vol 108, Iss 3 (2022)
Here we present the 3-year results of ZUMA-4, a phase I/II multicenter study evaluating the safety and efficacy of KTEX19, an autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy, in pediatric/adolescent patients with relapsed/refracto
Externí odkaz:
https://doaj.org/article/4597945ce7d14d1d8454e4c3ebda3fd1
Autor:
Sarah K. Tasian, Lewis B. Silverman, James A. Whitlock, Richard Sposto, Joseph P. Loftus, Eric S. Schafer, Kirk R. Schultz, Raymond J. Hutchinson, Paul S. Gaynon, Etan Orgel, Caroline M. Bateman, Todd M. Cooper, Theodore W. Laetsch, Maria Luisa Sulis, Yueh-Yun Chi, Jemily Malvar, Alan S. Wayne, Susan R. Rheingold
Publikováno v:
Haematologica, Vol 107, Iss 10 (2022)
Phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) signaling is commonly dysregulated in acute lymphoblastic leukemia (ALL). The TACL2014-001 phase I trial of the mTOR inhibitor temsirolimus in combination with cyclophosphamide
Externí odkaz:
https://doaj.org/article/8445bc9f98404419b1d22c8a88c190ec
Autor:
Chun-Hua Wu, Jingbo Li, Li Li, Jianping Sun, Muller Fabbri, Alan S. Wayne, Robert C. Seeger, Ambrose Y. Jong
Publikováno v:
Journal of Extracellular Vesicles, Vol 8, Iss 1 (2019)
Extracellular vesicles (EVs) are secreted membrane vesicles, which play complex physiological and pathological functions in intercellular communication. Recently, we isolated natural killer (NK) cell-derived EVs (NK-EVs) from ex vivo expansion of NK
Externí odkaz:
https://doaj.org/article/06d61625c7294be28451544698ddea20
Publikováno v:
Journal of Extracellular Vesicles, Vol 6, Iss 1 (2017)
Extracellular vesicles (EVs) deliver bioactive macromolecules (i.e. proteins, lipids and nucleic acids) for intercellular communication in multicellular organisms. EVs are secreted by all cell types including immune cells. Immune cell-derived EVs mod
Externí odkaz:
https://doaj.org/article/946a9529645c4eed8cb85f8b37d5a27c
Autor:
Ambrose Y. Jong, Chun-Hua Wu, Jingbo Li, Jianping Sun, Muller Fabbri, Alan S. Wayne, Robert C. Seeger
Publikováno v:
Journal of Extracellular Vesicles, Vol 6, Iss 1 (2017)
Extracellular vesicles (EVs) have been the focus of great interest, as they appear to be involved in numerous important cellular processes. They deliver bioactive macromolecules such as proteins, lipids, and nucleic acids, allowing intercellular comm
Externí odkaz:
https://doaj.org/article/5a05e1fcbefd496bbc33e829ee8e32f2
Publikováno v:
Toxins, Vol 10, Iss 5, p 210 (2018)
Moxetumomab pasudotox is a fusion protein of a CD22-targeting antibody and Pseudomonas exotoxin. Minutes of exposure to Moxetumomab achieves similar cell killing than hours of exposure to a novel deimmunized variant against some acute lymphoblastic l
Externí odkaz:
https://doaj.org/article/d36490e804f3404aa559fb0d7e8fd65e
Autor:
Etai Adam, Hye Na Kim, Eun Ji Gang, Caitlin Schnair, Solomon Lee, Solah Lee, Sajad Khazal, Osanna Kosoyan, Marina Konopleva, Chintan Parekh, Deepa Bhojwani, Alan S. Wayne, Hisham Abdel-Azim, Nora Heisterkamp, Yong-Mi Kim
Publikováno v:
Cancers, Vol 9, Iss 9, p 121 (2017)
The quest continues for targeted therapies to reduce the morbidity of chemotherapy and to improve the response of resistant leukemia. Adhesion of acute lymphoblastic leukemia (ALL) cells to bone marrow stromal cells triggers intracellular signals tha
Externí odkaz:
https://doaj.org/article/44ba12fc53cc44f4bfefaad86deddafa
Autor:
Armin G. Jegalian, Nataliya P. Buxbaum, Fabio Facchetti, Mark Raffeld, Stefania Pittaluga, Alan S. Wayne, Elaine S. Jaffe
Publikováno v:
Haematologica, Vol 95, Iss 11 (2010)
Background Blastic plasmacytoid dendritic cell neoplasm is a rare malignancy that typically follows a highly aggressive clinical course in adults, whereas experience in children with this disease is very limited.Design and Methods This retrospective
Externí odkaz:
https://doaj.org/article/b3012c68e73d449bac9d2282d14bd684
Autor:
Francesco Ceppi, Ashley L. Wilson, Colleen Annesley, Gabriella R. Kimmerly, Corinne Summers, Adam Brand, Kristy Seidel, Qian Vicky Wu, Adam Beebe, Christopher Brown, Stephanie Mgebroff, Catherine Lindgren, Stephanie D. Rawlings-Rhea, Wenjun Huang, Michael A. Pulsipher, Alan S. Wayne, Julie R. Park, Michael C. Jensen, Rebecca A. Gardner
Publikováno v:
Cancer Immunol Res
T cells modified to express a chimeric antigen receptor (CAR) targeting CD19 can induce potent and sustained responses in children with relapsed/refractory acute lymphoblastic leukemia (ALL). The durability of remission is related to the length of ti