Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Alan S. Waggoner"'
Autor:
Sandip A. Shelke, Yaming Shao, Artur Laski, Deepak Koirala, Benjamin P. Weissman, James R. Fuller, Xiaohong Tan, Tudor P. Constantin, Alan S. Waggoner, Marcel P. Bruchez, Bruce A. Armitage, Joseph A. Piccirilli
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
The DIR2s RNA aptamer activates the fluorescence of cyanine dyes allowing detection of two well-resolved emission colors. Here authors solve the crystal structures of the apo and OTB-SO3 fluorophore-bound DIR2s and show how the fluorophore ligand is
Externí odkaz:
https://doaj.org/article/7a5169ba2e1440eb811c773399e43486
Publikováno v:
Photochemistry and Photobiology. 95:406-410
Spectral properties and fluorogenic behaviors of five novel thiophene variants of Malachite Green (MG), termed MGTs, were determined. Appreciable changes as a function of homologation and substitution pattern, including absorption band positions and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c699770d4d0b575c2facd9b569b89c9e
https://doi.org/10.1111/php.13037
https://doi.org/10.1111/php.13037
Autor:
Alan S. Waggoner, Lauren K. Rochelle, Larry S. Barak, Veronica Lubkov, Marc G. Caron, Caroline A. Ray, Cheryl B. Bock, Thomas F. Pack, Joshua C. Snyder, H. Kim Lyerly
Publikováno v:
Journal of Biological Chemistry. 292:7208-7222
The leucine-rich G protein-coupled receptor-5 (LGR5) is expressed in adult tissue stem cells of many epithelia, and its overexpression is negatively correlated with cancer prognosis. LGR5 potentiates WNT/β-catenin signaling through its unique consti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::304a944c22f6fddcfc6a4f3d6fb7e601
https://doi.org/10.1074/jbc.m116.756635
https://doi.org/10.1074/jbc.m116.756635
Autor:
Alan S. Waggoner, Wen Liu, Yong Fan, Eric C. Freeman, Christina Bagia, Wilson S. Meng, Ellen S. Gawalt, Matthew J. Saunders
Publikováno v:
Journal of Controlled Release. 230:1-12
Herein we report an injectable film by which antibodies can be localized in vivo . The system builds upon a bifunctional polypeptide consisting of a fluorogen-activating protein (FAP) and a β-fibrillizing peptide (βFP). The FAP domain generates flu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f5e0c2963cd3f15b2a1d2399bb73fa0
https://doi.org/10.1016/j.jconrel.2016.03.032
https://doi.org/10.1016/j.jconrel.2016.03.032
Autor:
Gregory W. Fisher, Kristine Gouveia, Yang Wu, Shaun R. Stauffer, Alan S. Waggoner, Christopher Szent-Gyorgyi, Annette M. Evangelisti, Mike Poslusney, Cristian Bologa, Larry A. Sklar, Craig W. Lindsley, Anna Waller, Oleg Ursu, Jonathan W. Jarvik, Robyn L. Stanfield, Phillip H. Tapia, J. Jacob Strouse, Mark B. Carter
Publikováno v:
SLAS Discovery. 21:74-87
A new class of biosensors, fluorogen activating proteins (FAPs), has been successfully used to track receptor trafficking in live cells. Unlike the traditional fluorescent proteins (FPs), FAPs do not fluoresce unless bound to their specific small-mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6370374a2170d95abf28784c8d4b965
https://doi.org/10.1177/1087057115609145
https://doi.org/10.1177/1087057115609145
The goal of this work was to demonstrate that aprotinin conjugated to fibrinogen could (1) maintain its function and (2) control fibrin degradation. Using the chick chorioallantoic membrane (CAM) assay, we found that blood vessels did not directly in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50a18be37148fb502b4db317f8933a17
Autor:
Juan J. Rojas, Ming Zhang, Subhasish K. Chakraborty, Weizhou Hou, Marcel P. Bruchez, Steve H. Thorne, Saumya Saurabh, Padma Sampath, Alan S. Waggoner
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Universidad de Barcelona
Optical imaging of whole, living animals has proven to be a powerful tool in multiple areas of preclinical research and has allowed noninvasive monitoring of immune responses, tumor and pathogen growth, and treatment responses in longitudinal studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::478df5088febbd507f25bbf22998268d
https://doi.org/10.1172/jci81086
https://doi.org/10.1172/jci81086
Autor:
Alan S. Waggoner, Kimberly J. Zanotti, Wendy S. Brotherton, Brigitte F. Schmidt, Christopher Szent-Gyorgyi, Ha H. Pham, Bruce A. Armitage
Publikováno v:
Organic & Biomolecular Chemistry. 13:3699-3710
Dye-protein fluoromodules consist of fluorogenic dyes and single chain antibody fragments that form brightly fluorescent noncovalent complexes. This report describes two new bichromophoric dyes that extend the range of wavelengths of excitation or em
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6dbb2642c59622e1f0dbd115e14fabf
https://doi.org/10.1039/c4ob02522a
https://doi.org/10.1039/c4ob02522a
Autor:
Marcel P. Bruchez, Jyotsna Pilli, Mads Breum Larsen, Ming Zhang, Simon C. Watkins, Alan S. Waggoner, Jon W. Johnson, Joshua M. Lorenz-Guertin, Tija C. Jacob, Brigitte F. Schmidt, Madeleine R. Wilcox
Live-cell imaging methods can provide critical real-time receptor trafficking measurements. Here, we describe an optical tool to study synaptic γ-aminobutyric acid (GABA) type A receptor (GABAAR) dynamics through adaptable fluorescent-tracking capab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::207143637483b424bcc00f5927885173
https://europepmc.org/articles/PMC5702044/
https://europepmc.org/articles/PMC5702044/
Publikováno v:
Bioconjugate Chemistry
Monoclonal antibodies are one of the most useful and ubiquitous affinity reagents used in the biological sciences. Immunostaining of fixed and live cells for microscopy or cytometry measurements frequently employs fluorescently labeled antibodies, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::129937d391c77cd9780a16c51bab1481
https://doi.org/10.1021/bc500273n
https://doi.org/10.1021/bc500273n