Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Alan S. Futran"'
Autor:
Alan S. Futran, Tao Lu, Katherine Amberg-Johnson, Jiayi Xu, Xiaoxiao Yang, Saidi He, Sarah Boyce, Jeffrey A. Bell, Robert Pelletier, Takao Suzuki, Xianhai Huang, Heng Qian, Liping Fang, Li Xing, Zhaowu Xu, Stephen E. Kurtz, Jeffrey W. Tyner, Wayne Tang, Tao Guo, Karen Akinsanya, David Madge, Kristian K. Jensen
Publikováno v:
iScience, Vol 27, Iss 5, Pp 109693- (2024)
Summary: The USP7 deubiquitinase regulates proteins involved in the cell cycle, DNA repair, and epigenetics and has been implicated in cancer progression. USP7 inhibition has been pursued for the development of anti-cancer therapies. Here, we describ
Externí odkaz:
https://doaj.org/article/ad0bc59a163a477bae0474b6a3ff6a2d
Publikováno v:
Proceedings of the National Academy of Sciences. 112:8590-8595
Extracellular signal-regulated kinase (ERK) coordinates cellular responses to a range of stimuli by phosphorylating its numerous substrates. One of these substrates, Capicua (Cic), is a transcriptional repressor that was first identified in Drosophil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9aa001ff93bc74cfb5f194612e42f67
https://doi.org/10.1073/pnas.1501373112
https://doi.org/10.1073/pnas.1501373112
Autor:
Kei Yamaya, Trudi Schüpbach, Stanislav Y. Shvartsman, Alan S. Futran, Iason Kountouridis, Rebecca D. Burdine, Granton A. Jindal, Yogesh Goyal, Courtney A Balgobin
Germ-line mutations in components of the Ras/MAPK pathway result in developmental disorders called RASopathies, affecting about 1/1,000 human births. Rapid advances in genome sequencing make it possible to identify multiple disease-related mutations,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3d32bb583c33d69f5c61efebb66eee6
https://europepmc.org/articles/PMC5255624/
https://europepmc.org/articles/PMC5255624/
Autor:
Rebecca D. Burdine, Yogesh Goyal, Trudi Schüpbach, Jose L Pelliccia, Kei Yamaya, Granton A. Jindal, Eyan Yeung, Stanislav Y. Shvartsman, Alan S. Futran
Publikováno v:
Nature genetics. 49(3)
Germline mutations in Ras pathway components are associated with a large class of human developmental abnormalities, known as RASopathies, that are characterized by a range of structural and functional phenotypes, including cardiac defects and neuroc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e700997132c1d831b0e440ddcc6088b0
https://pubmed.ncbi.nlm.nih.gov/28166211
https://pubmed.ncbi.nlm.nih.gov/28166211
Publikováno v:
Current biology : CB. 23(21)
A key step towards a chemical picture of enzyme catalysis was taken in 1913, when Leonor Michaelis and Maud Menten published their studies of sucrose hydrolysis by invertase. Based on a novel experimental design and a mathematical model, their work o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0cb412de7b89b9ba899feede6a61ee9
https://pubmed.ncbi.nlm.nih.gov/24200329
https://pubmed.ncbi.nlm.nih.gov/24200329