Zobrazeno 1 - 10
of 231
pro vyhledávání: '"Alan S Wayne"'
Autor:
Armin Ghobadi, Ibrahim Aldoss, Shannon Maude, Alan S Wayne, Deepa Bhojwani, Ashish Bajel, Bhagirathbhai Dholaria, Rawan Faramand, Ryan Mattison, Michael Rettig, Ouiam Bakkacha, John Muth, Angela Pannunzio, Brett Ramsey, Eileen Mcnulty, Matthew Cooper, Jan Davidson-Moncada, Kenneth Jacobs, John Dipersio
Publikováno v:
HemaSphere, Vol 7, p e1789302 (2023)
Externí odkaz:
https://doaj.org/article/54e632fd8a1741b4b44130773003313c
Autor:
Hema Dave, Miriam R Anver, Donna O Butcher, Patrick Brown, Javed Khan, Alan S Wayne, Sivasubramanian Baskar, Christoph Rader
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52655 (2012)
Despite high cure rates for pediatric B-lineage acute lymphoblastic leukemia (B-ALL), short-term and long-term toxicities and chemoresistance are shortcomings of standard chemotherapy. Immunotherapy and chemoimmunotherapy based on monoclonal antibodi
Externí odkaz:
https://doaj.org/article/d7cbb8cb33014e3c8c5d5f5be6d5c12b
Autor:
Chun-Hua Wu, Jingbo Li, Li Li, Jianping Sun, Muller Fabbri, Alan S. Wayne, Robert C. Seeger, Ambrose Y. Jong
Publikováno v:
Journal of Extracellular Vesicles, Vol 8, Iss 1 (2019)
Extracellular vesicles (EVs) are secreted membrane vesicles, which play complex physiological and pathological functions in intercellular communication. Recently, we isolated natural killer (NK) cell-derived EVs (NK-EVs) from ex vivo expansion of NK
Externí odkaz:
https://doaj.org/article/06d61625c7294be28451544698ddea20
Autor:
Rebecca A. Gardner, Michael C. Jensen, Julie R. Park, Alan S. Wayne, Michael A. Pulsipher, Wenjun Huang, Stephanie D. Rawlings-Rhea, Catherine Lindgren, Stephanie Mgebroff, Christopher Brown, Adam Beebe, Qian Vicky Wu, Kristy Seidel, Adam Brand, Corinne Summers, Gabriella R. Kimmerly, Colleen Annesley, Ashley L. Wilson, Francesco Ceppi
T cells modified to express a chimeric antigen receptor (CAR) targeting CD19 can induce potent and sustained responses in children with relapsed/refractory acute lymphoblastic leukemia (ALL). The durability of remission is related to the length of ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::363b59482bf591f9a4d029b35fb989f1
https://doi.org/10.1158/2326-6066.c.6550635
https://doi.org/10.1158/2326-6066.c.6550635
Autor:
Rebecca A. Gardner, Michael C. Jensen, Julie R. Park, Alan S. Wayne, Michael A. Pulsipher, Wenjun Huang, Stephanie D. Rawlings-Rhea, Catherine Lindgren, Stephanie Mgebroff, Christopher Brown, Adam Beebe, Qian Vicky Wu, Kristy Seidel, Adam Brand, Corinne Summers, Gabriella R. Kimmerly, Colleen Annesley, Ashley L. Wilson, Francesco Ceppi
Supplementary Data from Modified Manufacturing Process Modulates CD19CAR T-cell Engraftment Fitness and Leukemia-Free Survival in Pediatric and Young Adult Subjects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49d4d6f0f3631018757125e35698724b
https://doi.org/10.1158/2326-6066.22544421
https://doi.org/10.1158/2326-6066.22544421
HA22 (Moxetumomab pasudotox) is a recombinant immunotoxin (RIT), composed of an anti-CD22 Fv fused to a truncated portion of Pseudomonas exotoxin A. HA22 is in clinical trials to treat patients with hairy cell leukemia and acute lymphoblastic leukemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53691f1f4ebe5c4c60ca83df3f5a93bb
https://doi.org/10.1158/1535-7163.c.6538782
https://doi.org/10.1158/1535-7163.c.6538782
Fig S1. H89 increased ADP-ribosylation and MCL-1 degradation in SEM cells Fig S2. Combination of RIT and H89 lowers MCL1 and induces PARP-cleavage Fig S3. PKA regulator, S6K1-, or ROCK2-inhibitor show little change in LMB-11 activity Fig S4. Combinat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26966be058d0ff9c2065371388d2a783
https://doi.org/10.1158/1535-7163.22507776.v1
https://doi.org/10.1158/1535-7163.22507776.v1
Figure S1. KOPN-8 from murine BM has similar levels of CD22 and RIT sensitivity as in cell culture Figure S2. LMB-11-Alexa 647 in KOPN-8 from murine BM reaches maximal signal intensity after only 1 h circulation time Figure S3. Compared to the most a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37ad57fc44d26ae4f0ac62ee670f3e60
https://doi.org/10.1158/1078-0432.22460082
https://doi.org/10.1158/1078-0432.22460082
Purpose: Recombinant immunotoxins (rITs) targeting CD22 are highly active in hairy cell leukemia, but less so in acute lymphoblastic leukemia (ALL). This study aims to understand the variable activity of an rIT against ALL toward improving responses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90c1eb1a8a8a5ab2a2aa5d0710acd9da
https://doi.org/10.1158/1078-0432.c.6524397
https://doi.org/10.1158/1078-0432.c.6524397
Autor:
Francesco Ceppi, Ashley L. Wilson, Colleen Annesley, Gabriella R. Kimmerly, Corinne Summers, Adam Brand, Kristy Seidel, Qian Vicky Wu, Adam Beebe, Christopher Brown, Stephanie Mgebroff, Catherine Lindgren, Stephanie D. Rawlings-Rhea, Wenjun Huang, Michael A. Pulsipher, Alan S. Wayne, Julie R. Park, Michael C. Jensen, Rebecca A. Gardner
Publikováno v:
Cancer Immunol Res
T cells modified to express a chimeric antigen receptor (CAR) targeting CD19 can induce potent and sustained responses in children with relapsed/refractory acute lymphoblastic leukemia (ALL). The durability of remission is related to the length of ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8108b1c6d3d653f46a24feed6803d24d
https://doi.org/10.1158/2326-6066.cir-21-0501
https://doi.org/10.1158/2326-6066.cir-21-0501