In an Ovine Model of Polycystic Ovary Syndrome (PCOS) Prenatal Androgens Suppress Female Fetal Renal Gluconeogenesis.

Autor: Fiona Connolly, Michael T Rae, Katharina Späth, Lyndsey Boswell, Alan S McNeilly, W Colin Duncan

Publikováno v: PLoS ONE, Vol 10, Iss 7, p e0132113 (2015)

Increased maternal androgen exposure during pregnancy programmes a polycystic ovary syndrome (PCOS)-like condition, with metabolic dysfunction, in adult female offspring. Other in utero exposures associated with the development of insulin resistance,

Externí odkaz: https://doaj.org/article/d1cf8f989eb24bc286894dde8a4b0811

The pancreas is altered by in utero androgen exposure: implications for clinical conditions such as polycystic ovary syndrome (PCOS).

Autor: Mick Rae, Cathal Grace, Kirsten Hogg, Lisa Marie Wilson, Sophie L McHaffie, Seshadri Ramaswamy, Janis MacCallum, Fiona Connolly, Alan S McNeilly, Colin Duncan

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e56263 (2013)

Using an ovine model of polycystic ovary syndrome (PCOS), (pregnant ewes injected with testosterone propionate (TP) (100 mg twice weekly) from day (d)62 to d102 of d147 gestation (maternal injection - MI-TP)), we previously reported female offspring

Externí odkaz: https://doaj.org/article/62c66d10f36048acb70728a3a367bdb0

Circadian clock mechanism driving mammalian photoperiodism

Autor: Helen C. Christian, Andrew S. I. Loudon, Matthew Hindle, Yasutaka Mizoro, Dave Burt, Ben Saer, Shona H. Wood, Judith McNeilly, Alan S. McNeilly, Yung Sung Cheng, Katarzyna Miedzinska, Simone Meddle, Nicola Begley

Publikováno v: Wood, S, Hindle, M, Mizoro, Y, Cheng, Y, Saer, B, Miedzinska-Bielecka, K, Christian, H, Begley, N, J, M, McNeilly, A, Meddle, S, Burt, D & Loudon, A 2020, ' Circadian clock mechanism driving mammalian photoperiodism. ', Nature Communications, vol. 11, 4291 (2020), pp. 1-15 . https://doi.org/10.1038/s41467-020-18061-z
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Wood, S, Hindle, M M, Mizoro, Y, Cheng, Y, Saer, B, Miedzinska, K, Christian, H C, Begley, N, McNeilly, J, McNeilly, A S, Meddle, S L, Burt, D W & Loudon, A 2020, ' Circadian clock mechanism driving mammalian photoperiodism ', Nature Communications, vol. 11, 4291 . https://doi.org/10.1038/s41467-020-18061-z

The annual photoperiod cycle provides the critical environmental cue synchronizing rhythms of life in seasonal habitats. In 1936, Bünning proposed a circadian-based coincidence timer for photoperiodic synchronization in plants. Formal studies suppor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbe68ec4d59282f4ea3b26b1fb3be070
https://hdl.handle.net/20.500.11820/5e075f9c-9115-4113-8aa7-1d78e2ed165d

Inhibin and oestradiol in the control of FSH secretion in the sheep

Autor: Alan S. McNeilly, David T. Baird, Bruce K. Campbell, George E Mann

Publikováno v: Bioscientifica Proceedings.

In the sheep both FSH and LH are necessary for development of large antral follicles. The secretion of FSH is controlled by the negative feedback effect of two ovarian hormones, oestradiol and inhibin, acting at the level of the anterior pituitary. B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c478725a2f9b8bbe898f106127a2c9d2
https://doi.org/10.1530/biosciprocs.2.010

Gonadotrophic control of follicle growth in the ewe

Autor: Alan S. McNeilly, Bruce K. Campbell, Helen M. Picton, D. T. Baird

Publikováno v: Bioscientifica Proceedings.

Preovulatory follicle growth in the ewe is dependent on FSH although no precise relationship appears to exist between plasma concentrations of FSH and the number of preovulatory follicles which develop or ovulation rate. This may be related to a hith

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9429e38ec869b94b886487762db18ee8
https://doi.org/10.1530/biosciprocs.2.014