Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Alan Rosales"'
Autor:
David N. Fiflis, Nicolas A. Rey, Harshitha Venugopal-Lavanya, Beatrice Sewell, Aaron Mitchell-Dick, Katie N. Clements, Sydney Milo, Abigail R. Benkert, Alan Rosales, Sophia Fergione, Aravind Asokan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Type VI CRISPR enzymes have been developed as programmable RNA-guided Cas proteins for eukaryotic RNA editing. Notably, Cas13 has been utilized for site-targeted single base edits, demethylation, RNA cleavage or knockdown and alternative spl
Externí odkaz:
https://doaj.org/article/4a9e799fbf1b4f619012e055594df9cf
Autor:
Mercedes Barzi, Tong Chen, Trevor J. Gonzalez, Francis P. Pankowicz, Seh Hoon Oh, Helen L. Streff, Alan Rosales, Yunhan Ma, Sabrina Collias, Sarah E. Woodfield, Anna Mae Diehl, Sanjeev A. Vasudevan, Thao N. Galvan, John Goss, Charles A. Gersbach, Beatrice Bissig-Choisat, Aravind Asokan, Karl-Dimiter Bissig
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Clinical translation of AAV-mediated gene therapy requires preclinical development across different experimental models, often confounded by variable transduction efficiency. Here, we describe a human liver chimeric transgene-free Il2rg −/
Externí odkaz:
https://doaj.org/article/3464bdb424c442108002dbd891da2d8d
Autor:
Ezra J. Loeb, Patrick L. Havlik, Zachary C. Elmore, Alan Rosales, Sophia M. Fergione, Trevor J. Gonzalez, Timothy J. Smith, Abigail R. Benkert, David N. Fiflis, Aravind Asokan
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113902- (2024)
Summary: Adeno-associated virus (AAV) is a member of the genus Dependoparvovirus, which infects a wide range of vertebrate species. Here, we observe that, unlike most primate AAV isolates, avian AAV is transcriptionally silenced in human cells. By sw
Externí odkaz:
https://doaj.org/article/80e360eb884e4f9ebe6cb54049ee9c77
Autor:
Mercedes Barzi, Collin G. Johnson, Tong Chen, Ramona M. Rodriguiz, Madeline Hemmingsen, Trevor J. Gonzalez, Alan Rosales, James Beasley, Cheryl K. Peck, Yunhan Ma, Ashlee R. Stiles, Timothy C. Wood, Raquel Maeso-Diaz, Anna Mae Diehl, Sarah P. Young, Jeffrey I. Everitt, William C. Wetsel, William R. Lagor, Beatrice Bissig-Choisat, Aravind Asokan, Areeg El-Gharbawy, Karl-Dimiter Bissig
Publikováno v:
Science Translational Medicine. 15
Glutaric aciduria type I (GA-1) is an inborn error of metabolism with a severe neurological phenotype caused by the deficiency of glutaryl–coenzyme A dehydrogenase (GCDH), the last enzyme of lysine catabolism. Current literature suggests that toxic
Autor:
Mercedes Barzi, Collin Johnson, Tong Chen, Ramona Rodriguiz, Madeline Hemmingsen, Trevor J. Gonzalez, Alan Rosales, James Beasley, Yunhan Ma, Ashlee R. Stiles, Timothy C. Wood, Raquel Maeso-Diaz, Ana Mae Diehl, Sarah P. Young, Jeffrey I. Everitt, William C. Wetsel, Beatrice Bissig-Choisat, Aravind Asokan, Areeg El-Gharbawy, Karl-Dimiter Bissig
Publikováno v:
Molecular Genetics and Metabolism. 138:107377
Autor:
William A. Nyberg, Jonathan Ark, Angela To, Sylvanie Clouden, Gabriella Reeder, Joseph J. Muldoon, Jing-Yi Chung, William H. Xie, Vincent Allain, Zachary Steinhart, Christopher Chang, Alexis Talbot, Sandy Kim, Alan Rosales, L. Patrick Havlik, Harold Pimentel, Aravind Asokan, Justin Eyquem
Publikováno v:
Cell. 186:446-460.e19
Autor:
Xiaobo Gao, Vivette D. D'Agati, Michael W. Ross, Zhengzi Yi, Geetha M. Bommana, Alan Rosales, Buadi Tandoh, Heidi Karttunen, Weijia Zhang, Zainab Habib
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports
Scientific Reports
HIV-associated nephropathy (HIVAN) is a rapidly progressive kidney disease that is caused by HIV infection of renal epithelial cells with subsequent expression of viral genes, including vpr. Antiretroviral therapy ameliorates HIVAN without eradicatin
Autor:
Zhengzi Yi, Geetha M. Bommana, Zainab Habib, Buadi Tandoh, Heidi Karttunen, Weijia Zhang, Alan Rosales, Xiaobo Gao, Michael W. Ross, Vivette D. D'Agati
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.