Výsledky vyhledávání - "Alan Robert Brown"

Potent hypocholesterolemic activity of novel ureido phenoxyisobutyrates correlates with their intrinsic fibrate potency and not with their ACAT inhibitory activity

Autor: Deborah A. Winegar, Carl W. Sigel, James Chapman, Jo A. Salisbury, Roy L. Hawke, Alan Robert Brown, Richard M. Welch, Karl Witold Franzmann

Publikováno v: Journal of Lipid Research, Vol 38, Iss 6, Pp 1189-1203 (1997)

The hypocholesterolemic activity for novel ureido fibrate analogues was found to be over 100-fold greater than for any “second-generation” fibrate in cholesterol-fed rats. A comparison of 12 related analogues revealed that the optimal configurati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe5541442dfd2e4e477f3eab885edfdd
https://doi.org/10.1016/s0022-2275(20)37201-1

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Fibrates induce hepatic peroxisome and mitochondrial proliferation without overt evidence of cellular proliferation and oxidative stress in cynomolgus monkeys

Autor: Rosanna C. Mirabile, Carie L. Kimbrough, Charles W. Qualls, Richard T. Miller, Zhiyang Zhao, Steven P. Anderson, H. Roger Brown, M. Santostefano, Heidi M. Colton, William B. Oliver, Debie J. Hoivik, Paul N. Mudd, Ray R. Dahl, Ronda J. Ott Morgan, Alan Robert Brown, Neal F. Cariello

Publikováno v: Carcinogenesis. 25(9)

There is little primate risk factor data in the literature evaluating the relationship between proposed mechanisms of PPAR agonist-induced hepatocarcinogenesis at clinically relevant therapeutic exposures. These studies were conducted to characterize

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41e34e87dcec63939943e3f639cf1160
https://pubmed.ncbi.nlm.nih.gov/15131011

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The in vitro degradation of cisatracurium, the R, cis-R'-isomer of atracurium, in human and rat plasma

Autor: Ray R. Dahl, Josh Ravitch, Alan Robert Brown, Richard M. Welch

Publikováno v: Clinical pharmacology and therapeutics. 58(2)

Objective To assess the mechanism and rate of in vitro degradation of cisatracurium in aqueous buffer and in human and rat plasma. Methods Cisatracurium was incubated in aqueous buffer at various pH values or in human and rat plasma maintained at pH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37a843a26df3356c75049899a1185a85
https://pubmed.ncbi.nlm.nih.gov/7648763

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Stereoselective high-performance liquid chromatographic assay with fluorometric detection for the isomers of mivacurium in human plasma

Autor: Richard M. Welch, Charles D. James, Alan Robert Brown, Jane Croft Harrelson

Publikováno v: Journal of chromatography. 578(2)

A high-performance liquid chromatographic assay with fluorometric detection was developed for the analysis of the stereoisomers of mivacurium, a new short-acting neuromuscular blocker, in plasma. The isomers were isolated from plasma by solid-phase e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6cfef4cdfa8afa80de0d1863c8b8ea1
https://pubmed.ncbi.nlm.nih.gov/1400811

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Quantitation of the anticonvulsant cinromide (3-bromo-n-ethylcinnamamide) and its major plasma metabolites by thin-layer chromatography

Autor: Richard M. Welch, Alan Robert Brown, Maureen Robinson, R.L. DeAngelis, T.E. Johnson

Publikováno v: Journal of Chromatography B: Biomedical Sciences and Applications. 221:353-360

A quantitative thin-layer chromatography (TLC) procedure is described for the analysis of cinromide (3-bromo-N-ethylcinnamamide) and its two major metabolites, 3-bromocinnamamide and 3-bromocinnamic acid in plasma of the dog. These compounds were rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9da73e3a786a2e2ad76fb11e029b8e2
https://doi.org/10.1016/s0378-4347(00)84321-2

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