Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Alan R. Williamson"'
The Immune System: Genes Receptors, Signals provides information pertinent to the complexity of immune mechanisms. This book describes the immune response genes and products, which point to another multigene system controlling immune responsiveness.
Autor:
Alan R. Williamson
Publikováno v:
Trends in Genetics. 17:670-673
Why should patents be granted on genes? This question is a provocative and troubling issue currently facing society. Looking at the commercial realities of gene patents, I conclude that on balance their effect is to retard, rather than to stimulate,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e08cf049f1fe1da4fdb2f980215acce4
https://doi.org/10.1016/s0168-9525(01)02491-x
https://doi.org/10.1016/s0168-9525(01)02491-x
Autor:
Alan R. Williamson
Publikováno v:
Drug Discovery Today. 4:115-122
The Merck Gene Index project (MGIP) fills an important niche in the Human Genome Project by directly identifying genes through sequences of their transcripts and placing in the public domain a set of EST sequences and associated clones for the unique
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::189a415aed406915334543851ad42ef8
https://doi.org/10.1016/s1359-6446(99)01303-3
https://doi.org/10.1016/s1359-6446(99)01303-3
A TACROLIMUS-RELATED IMMUNOSUPPRESSANT WITH BIOCHEMICAL PROPERTIES DISTINCT FROM THOSE OF TACROLIMUS
Autor:
Mary M. Martin, Laurence B. Peterson, Gregory J. Wiederrecht, Janey N. Parsons, William H. Parsons, Peter J. Sinclair, Mary Beth Wilusz, Frederick Wong, John G. Cryan, Stephen J. O'Keefe, Matthew J. Wyvratt, Ray Rosa, Nolan H. Sigal, Alan R. Williamson
Publikováno v:
Transplantation. 65:10-18
Background Tacrolimus (FK506) is an immunosuppressive drug 50-100 times more potent than cyclosporine (CsA), the current mainstay of organ transplant rejection therapy. Despite being chemically unrelated, CsA and tacrolimus exert their immunosuppress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d629f9f28c4924d99389136bd19b5cd
https://doi.org/10.1097/00007890-199801150-00004
https://doi.org/10.1097/00007890-199801150-00004
Autor:
Alan R. Williamson
Publikováno v:
Science. 278:785-789
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f3c2187bfd1311f663b6989c193ff4c
https://doi.org/10.1126/science.278.5339.785a
https://doi.org/10.1126/science.278.5339.785a
Autor:
H J Zweerink, William E. Biddison, Maureen C. Gammon, Samir Y. Sauma, Julio C. Hawkins, Bruce L. Bush, Snehal Tamhankar, Maria A. Bednarek, Gene Porter, Alan R. Williamson, Barry R. Cunningham, Jeffrey D. Hermes
Publikováno v:
Human Immunology. 37:252-258
Experiments were carried out to determine whether complexes between MHC class I molecules and synthetic peptides are representative of those formed under more physiologically relevant conditions, with peptides derived intracellularly from processed a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e9df80d8f31760299a2dc2c3d0c1e0c
https://doi.org/10.1016/0198-8859(93)90508-x
https://doi.org/10.1016/0198-8859(93)90508-x
Publikováno v:
Trends in Pharmacological Sciences. 18:303-305
The principality of Monaco was the setting for a conference* on the utilization of the information being generated by the Human Genome Project (HGP). After successful conferences covering this area in the United States of America, this meeting organi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58266979de5472bd24603ab4685f017e
https://doi.org/10.1016/s0165-6147(97)90647-7
https://doi.org/10.1016/s0165-6147(97)90647-7
Autor:
Alan R. Williamson
Publikováno v:
Drug discovery today. 6(21)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3e2a2f7aa3832d5ac2e0d7bfaf7e924
https://pubmed.ncbi.nlm.nih.gov/11677160
https://pubmed.ncbi.nlm.nih.gov/11677160
Autor:
Joseph A. Borkowski, Jeffery S. Aaronson, Keith O. Elliston, Alan R. Williamson, Richard A. Blevins, Wendy J. Bailey, Barbara A. Eckman
Publikováno v:
Bioinformatics (Oxford, England). 14(1)
MOTIVATION: To make effective use of the vast amounts of expressed sequence tag (EST) sequence data generated by the Merck-sponsored EST project and other similar efforts, sequences must be organized into gene classes, and scientists must be able to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::175db5ba7c91ea4a439f6112aff75555
https://pubmed.ncbi.nlm.nih.gov/9520496
https://pubmed.ncbi.nlm.nih.gov/9520496
Autor:
Peter J. Sinclair, Gloria C. Koo, Alan R. Williamson, Irwin I. Singer, John R. Woods, Carolyn DaSilva, A Talento, Jeanne Barker, James V. Pivnichny, Nolan H. Sigal, Matthew J. Wyvratt, Frederick Wong, Francis J. Dumont, Samuel Koprak, William H. Parsons, Mary Jo Staruch
Publikováno v:
Transplantation. 65(1)
Tacrolimus (FK506) has potent immunosuppressive properties reflecting its ability to block the transcription of lymphokine genes in activated T cells through formation of a complex with FK506 binding protein-12, which inhibits the phosphatase activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3710846276c0a4f7c3b98ed9b5a08536
https://pubmed.ncbi.nlm.nih.gov/9448138
https://pubmed.ncbi.nlm.nih.gov/9448138