Výsledky vyhledávání - "Alan R. P. Paterson"

Cytotoxicity of 2-chlorodeoxyadenosine and arabinosylcytosine in leukaemic lymphoblasts from paediatric patients: significance of cellular nucleoside transporter content

Autor: John J. Akabutu, Wendy P. Gati, Adrienne M. P. Wright, Alan R. P. Paterson, Paul E. Grundy, Bernard Sowa

Publikováno v: British Journal of Haematology. 116:528-537

Summary. 2-chlorodeoxyadenosine (2-CdA) and arabinosylcytosine (araC) are nucleoside drugs that are used to treat various leukaemias, although 2-CdA has not been tested extensively in children with acute lymphoblastic leukaemia (ALL). Nucleoside cyto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b871dc722fa04e7223242cb991bb1426
https://doi.org/10.1046/j.0007-1048.2001.03300.x

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Enhancement of retention and cytotoxicity of 2-chlorodeoxyadenosine in cultured human leukemic lymphoblasts by nitrobenzylthioinosine, an inhibitor of equilibrative nucleoside transport

Autor: Alan R. P. Paterson, A. M. P. Wright, Wendy P. Gati

Publikováno v: Leukemia. 14:52-60

In leukemic cells exposed to 2-chlorodeoxyadenosine (2-CdA), levels of the nucleoside drug and its phosphate metabolites decay with time in the absence of external 2-CdA; an intrinsic part of this process is the efflux of 2-CdA. The effects of nitrob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4e0983563cebbeb8e31cb6965556359
https://doi.org/10.1038/sj.leu.2401633

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Measurement of nitrobenzylthioinosine in plasma and erythrocytes: a pharmacokinetic study in mice

Autor: Wendy P. Gati, Alan R. P. Paterson

Publikováno v: Cancer Chemotherapy and Pharmacology. 40:342-346

Purpose: Nitrobenzylthioinosine (NBMPR), a potent inhibitor of nucleoside transport in many cell types, modulates the in vivo disposition of several cytotoxic nucleoside analogs. In this study, a radioligand binding assay was developed for measuremen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93e8e589c3e2250bda8e65ebe828374a
https://doi.org/10.1007/s002800050667

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Synthesis of Substituted-Benzyl and Sugar-Modified Analogues of 6-N-(4-Nitrobenzyl)adenosine and Their Interactions with 'ES' Nucleoside Transport Systems

Autor: Carol E. Cass, Ewa S. Jakobs, Francisca R. Agbanyo, Jun-ichi Asakura, Masakatsu Kaneko, Susumu Shibuya, Morris J. Robins, Alan R. P. Paterson

Publikováno v: Nucleosides and Nucleotides. 13:1627-1646

Four classes of 6-X-benzylated purine nucleosides, (i) 6-N-(substituted-benzyl)adenosines, (ii) 6-N-(4-nitrobenzyl)adenine nucleosides with modified sugars, (iii) 6-N(S)-(4-azidobenzyl) derivatives of adenosine, 6-thioinosine, and 6-thioguanosine, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7cb2c3c25abed33606011df5890a059d
https://doi.org/10.1080/15257779408012177

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Cloning and functional expression of a complementary DNA encoding a mammalian nucleoside transport protein

Autor: Qi Quan Huang, Carol E. Cass, Sylvia Y.M. Yao, Mabel W.L. Ritzel, Alan R. P. Paterson, James D. Young

Publikováno v: Journal of Biological Chemistry. 269:17757-17760

Expression screening in Xenopus oocytes was used to isolate a cDNA from rat jejunal epithelium encoding a Na(+)-dependent nucleoside transport protein (named cNT1). The cDNA sequence of cNT1 predicts a protein of 648 amino acids (relative molecular m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::407da8aca5176d167df994a3b5b42957
https://doi.org/10.1016/s0021-9258(17)32370-0

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Functional expression of the nitrobenzylthioinosine-sensitive nucleoside transporter of human choriocarcinoma (BeWo) cells in isolated oocytes of Xenopus laevis

Autor: Carol E. Cass, C E Boumah, Catherine M. Harvey, Stephen A. Baldwin, James D. Young, Alan R. P. Paterson

Publikováno v: Biochemical Journal. 299:769-773

Cultured human choriocarcinoma (BeWo) cells have previously been shown to exhibit, in comparison with other cultured cell types, elevated nitrobenzylthioinosine (NBMPR)-sensitive transport activity and large numbers (> 10(7)/cell) of high-affinity NB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b3a8c04c43c5b37bc0d5d840d1f11cd
https://doi.org/10.1042/bj2990769

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Conjugates of Fluorescein and Saenta (5′-S-(2-Aminoethyl)-N6-(4-nitrobenzyl)-5′-thioadenosine): Flow Cytometry Probes for theESNucleoside Transporter Elements of the Plasma Membrane

Autor: Carol E. Cass, Morris J. Robins, John K. Buolamwini, Alan R. P. Paterson, Wendy P. Gati, James D. Craik, James S. Wiley

Publikováno v: Nucleosides and Nucleotides. 13:737-751

SAENTA was linked to the C-5 or C-6 positions of fluorescein through several structures to form conjugates that were bound tightly to plasma membrane sites associated with es nucleoside transport activity. The conjugates imparted fluorescence to cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1abb851de911d052084cded999536558
https://doi.org/10.1080/15257779408013276

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Inhibitory effects of propentofylline on [3H]adenosine influx

Autor: Fiona E. Parkinson, Carol E. Cass, Alan R. P. Paterson, James D. Young

Publikováno v: Biochemical Pharmacology. 46:891-896

The neuroprotective effects of adenosine are well-recognized. Recently, propentofylline, a xanthine derivative, has been shown to increase extracellular concentrations of adenosine in ischemie brain and to limit the extent of neuronal damage in exper

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8153ef612b90e6b29793b312842a6f0d
https://doi.org/10.1016/0006-2952(93)90499-m

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Functional expression of Na(+)-dependent nucleoside transport systems of rat intestine in isolated oocytes of Xenopus laevis. Demonstration that rat jejunum expresses the purine-selective system N1 (cif) and a second, novel system N3 having broad specificity for purine and pyrimidine nucleosides

Autor: Qi Quan Huang, Carol E. Cass, Alan R. P. Paterson, James D. Young, Catherine M. Harvey

Publikováno v: Journal of Biological Chemistry. 268:20613-20619

Isolated stage VI oocytes from Xenopus laevis expressed uridine transport activity after microinjection of mRNA from rat jejunum. Uridine uptake during 30 min (10 microM, 20 degrees C) by mRNA-injected oocytes reached 2.5 pmol/oocyte, compared with e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0cb4f85b3c20ea8b99426acfc15327c5
https://doi.org/10.1016/s0021-9258(20)80769-8

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