Výsledky vyhledávání - "Alan R. Giles"

A combination of factor Xa and phosphatidylcholine-phosphatidylserine vesicles bypasses factor VIII in vivo

Autor: Kenneth G. Mann, Alan R. Giles, Michael E. Nesheim

Publikováno v: British Journal of Haematology. 69:491-497

A combination of phosphatidylcholine-phosphatidylserine lipid vesicles (PCPS), as a source of coagulant active phospholipid, when infused with factor Xa bypasses factor VIII in vivo. To demonstrate this, a reproducible model of bleeding in haemophili

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fc34aac28455aedc1ce48afe2906df7e
https://doi.org/10.1111/j.1365-2141.1988.00483.x-i1

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Preclinical experiment of auxiliary partial orthotopic liver transplantation as a curative treatment for hemophilia

Autor: Midori Shima, Saiho Ko, Ichiro Tanaka, Yoshiyuki Nakajima, Hiromichi Kanehiro, Akira Yoshioka, Jun-ichi Ori, Alan R. Giles, Hideki Kanokogi

Publikováno v: Liver Transplantation. 11:579-584

The cause of hemophilia is deficiency of coagulation factor VIII production in the liver, which can be cured by liver transplantation. Because the hepatic function of hemophilia patients is quite normal except for production of factor VIII, auxiliary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::015889d3096fc8f08bb066389fd57c88
https://doi.org/10.1002/lt.20390

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The Utility of activated Partial Thromboplastin Time (aPTT) Clot Waveform Analysis in the Investigation of Hemophilia A Patients with very Low Levels of Factor VIII Activity (FVIII:C)

Autor: Midori Shima, Alan R. Giles, Kazuyoshi Fukuda, Youko Kubota, Akira Yoshioka, Katumi Nishiya, Tomoko Matsumoto, Ichiro Tanaka

Publikováno v: Thrombosis and Haemostasis. 87:436-441

SummaryThe lower detection limit of the conventional one-stage aPTT based clotting assay for determining FVIII:C levels is generally 1.0-2.0 IU/dl. Consequently, it has been impossible to study the clinical significance of levels of FVIII:C less than

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5218eb61cec210ef2252150429cf22ca
https://doi.org/10.1055/s-0037-1613023

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The Type of Factor VIII Deficient Plasma Used Influences the Performance of the Nijmegen Modification of the Bethesda Assay for Factor VIII Inhibitors

Autor: Bert Verbruggen, John A. Samis, Kitty Verbeek, Irena Novakova, Alan R. Giles, Ewald J.B.M. Mensink

Publikováno v: Thrombosis and Haemostasis. 86:1435-1439

SummaryWe have investigated the influence of the type of factor VIII deficient plasma used on the assay results of the Nijmegen modification of the Bethesda method for factor VIII inhibitors. Immuno depleted factor VIII deficient plasmas, lacking bes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3877a8793cf8f700d48360e900fc0aa8
https://doi.org/10.1055/s-0037-1616765

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Aortic endothelial cell von Willebrand factor content, and circulating plasminogen activator inhibitor-1 are increased, but expression of endothelial leukocyte adhesion molecules is unchanged in insulin-dependent diabetic BB rats

Autor: Marnie DeReske, P. Marlene Absher, Mary Richardson, Alan R. Giles, Yotis A. Senis, Mark W.C. Hatton, John A. Samis, Donald H. Maurice, José C.O Ribau

Publikováno v: Atherosclerosis. 149:331-342

Endothelial cell injury has been implicated in the increased incidence of vascular disease associated with diabetes mellitus. In diabetic humans, elevated plasma von Willebrand Factor (vWF) has been interpreted as an indication of endothelial damage.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94cfc9d3a8762ae618561ee36c9611fe
https://doi.org/10.1016/s0021-9150(99)00344-5

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Proteolytic processing of human coagulation factor IX by plasmin

Autor: Michael E. Nesheim, John Walker, Gillian D. Ramsey, John A. Samis, Alan R. Giles

Publikováno v: Blood. 95:943-951

Previous studies have shown that thrombin generation in vivo caused a 92% decrease in factor IX (F.IX) activity and the appearance of a cleavage product after immunoblotting that comigrated with activated F.IX (F.IXa). Under these conditions, the fib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::91e92758670f8d8e2a68bb31464e8604
https://doi.org/10.1182/blood.v95.3.943.003k34_943_951

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Activated thrombin‐activatable fibrinolysis inhibitor is generated in vivo at levels that can substantially affect fibrinolysis in chimpanzees in response to thrombin generation

Autor: Alan R. Giles, Paul Y. Kim, Paula Y.G. Kim, Hugh Hoogendorn, Michael E. Nesheim

Publikováno v: Journal of Thrombosis and Haemostasis. 6:1600-1602

Thrombin activatable fibrinolysis inhibitor (TAFI, proCPU) is a 60kDa plasma zymogen that circulates at a concentration of about 75nM [1]. It is activated by thrombin [2,3], the thrombin/thrombomodulin complex [4], or plasmin [5] by proteolytic cleav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2e1a6e1395029e0b2de1f29a618efa33
https://doi.org/10.1111/j.1538-7836.2008.03067.x

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Neutrophil Elastase Cleavage of Human Factor IX Generates an Activated Factor IX-Like Product Devoid of Coagulant Function

Autor: Eunice Kam, Alan R. Giles, John A. Samis, Michael E. Nesheim

Publikováno v: Blood. 92:1287-1296

In preliminary studies, the generation of thrombin in vivo was found to induce a 92% loss of functional activity of factor IX (F.IX) despite the detection by Western blotting of a product resembling activated F.IX (F.IXa) and a 25% increase in F.IX a

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https://doi.org/10.1182/blood.v92.4.1287

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Human Neutrophil Elastase Activates Human Factor V but Inactivates Thrombin-Activated Human Factor V

Autor: Alan R. Giles, Reginald P. Manuel, Michael E. Nesheim, John A. Samis, Marilyn Garrett

Publikováno v: Blood. 90:1065-1074

The effect of human neutrophil elastase (HNE) on human factor V (F.V) or α-thrombin–activated human factor V (F.Va) was studied in vitro by prothrombinase assays, sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), and NH2 -termi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ac44dd31cf9829bd1bbd602f2fbe397
https://doi.org/10.1182/blood.v90.3.1065

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