Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Alan R. Ferrie"'
Autor:
Gemma Victoria White, Duncan S. Holmes, Monika Rella, James H. Thorpe, Robert J. Young, Ann Louise Walker, Kathrine J. Smith, Emma V. Edgar, Alain Hovnanian, Oxana Polyakova, Ryan P. Bingham, Yichen Wang, Alan R. Ferrie, John Liddle
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:1454-1458
The connection between Netherton syndrome and overactivation of epidermal/dermal proteases particularly KLK5 has been well established. To treat sufferers of this severe condition we wished to develop a topical KLK5 inhibitor in order to normalise ep
Autor:
Andrew C. Pearce, Alexis Denis, Ann Louise Walker, Pam Nassau, Emma V. Edgar, Anne Marie Jeanne Bouillot, Lionel Trottet, Yichen Wang, Alain Hovnanian, Oxana Polyakova, Marie-Hélène Fouchet, Alexandre Moquette, Duncan S. Holmes, Alan R. Ferrie, Alain Laroze, Kathrine J. Smith, John Liddle, Ryan P. Bingham, Pamela Thomas, James H. Thorpe
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:126771
Autor:
Pam Nassau, Andrew C. Pearce, Lionel Trottet, Ann Louise Walker, Alexis Denis, Duncan S. Holmes, Pamela Thomas, Alan R. Ferrie, Kathrine J. Smith, Alexandre Moquette, James H. Thorpe, Emma V. Edgar, Anne Marie Jeanne Bouillot, Marie-Hélène Fouchet, Alain Laroze, John Liddle, Ryan P. Bingham, Alain Hovnanian, Oxana Polyakova, Yichen Wang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:126675
The connection between Netherton syndrome and overactivation of epidermal/dermal proteases, particularly Kallikrein 5 (KLK5) has been well established and it is expected that a KLK5 inhibitor would improve the dermal barrier and also reduce the pain
Autor:
Matthew D. Jones, Michelle L. Dawson, Robert Price, Jagdeep Shur, Alan R. Ferrie, Katrina Nichol, Graeme S. King, Camilla A. Mathoulin, Jennifer C. Hooton, Tracey L. Smith, Haggis Harris
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 69:496-507
The inclusion of different carrier materials in a dry powder inhaler (DPI) system can alter formulation performance, which might be attributable to variation in the adhesion between drug and carrier particles. The aim of this study was, therefore, to
Publikováno v:
International Journal of Pharmaceutics. 313:87-98
The physico-chemical behaviour of trehalose dihydrate during storage at low relative humidity and ambient temperature was investigated, using a combination of techniques commonly employed in pharmaceutical research. Weight loss, water content determi
Publikováno v:
Pharmaceutical research. 25(2)
To investigate the dispersion mechanism(s) of ternary dry powder inhaler (DPI) formulations by comparison of the interparticulate adhesions and in vitro performance of a number of carrier-drug-fines combinations.The relative levels of adhesion and co