Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Alan R. Dahl"'
Autor:
Hanspeter Witschi, D. Warner North, Roger A. Renne, John B. Morris, K.M. Abdo, Alan R. Dahl, Janet M. Benson
Publikováno v:
Regulatory Toxicology and Pharmacology. 51:6-14
This report provides a summary of deliberations conducted under the charge for members of Module A participating in the Naphthalene State-of-the-Science Symposium (NS3), Monterey, CA, October 9-12, 2006. Whole animal bioassays have been performed by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56425e00e42d28aee2841b879dc26168
https://doi.org/10.1016/j.yrtph.2007.09.022
https://doi.org/10.1016/j.yrtph.2007.09.022
Publikováno v:
Experimental Lung Research. 30:755-769
The inhalation delivery of difluoromethylornithine (DFMO) was evaluated to determine its feasibility for use in lung cancer chemoprevention. Aerosol droplets of DFMO were produced, and the solvent was removed by a reflux drying column. Equivalent dos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23b266c14857699e69948db62b93679f
https://doi.org/10.1080/01902140490517836
https://doi.org/10.1080/01902140490517836
Publikováno v:
Toxicology. 160:81-86
The carcinogenicity of 1,3-butadiene (BD) varies greatly in the rodent species in which 2-year bioassay studies were completed. This raises the question of whether the risk of BD exposure in humans is more like that of the sensitive species, the mous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6faa42e89f5d86209b29a68b6bc5d1a6
https://doi.org/10.1016/s0300-483x(00)00438-8
https://doi.org/10.1016/s0300-483x(00)00438-8
Autor:
Kristen J. Nikula, D A Kracko, G.L. Finch, Janice R. Thornton-Manning, S A Wardlaw, Alan R. Dahl
Publikováno v:
Carcinogenesis. 19:655-662
Enzymes of the nasal tissue, one of the first tissues to contact inhaled toxicants, are relatively resistant to induction by traditional inducers. Because tobacco smoke has been shown to induce cytochrome P450 1A1 (CYP1A1) in rat and human lung tissu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebf0180d20599e1ab8f5c1fb62983878
https://doi.org/10.1093/carcin/19.4.655
https://doi.org/10.1093/carcin/19.4.655
Publikováno v:
Carcinogenesis. 19:493-500
While inhaled polycyclic aromatic hydrocarbons have long been suspected to induce lung cancer in humans, their dosimetry has not been fully elucidated. A key question is whether the critical exposure occurs during absorption in the lungs, or if toxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5854c320396ad9c4e0f2d9e557d2b3ac
https://doi.org/10.1093/carcin/19.3.493
https://doi.org/10.1093/carcin/19.3.493
Publikováno v:
Toxicology Methods. 8:37-44
The authors have developed a simple, accurate method to combust low-level, tritium-containing tissue samples by modifying a tube furnace with two combustion zones. The sample is pyrolyzed upstream under a slow stream of argon, after which oxygen is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e48ed51c818b96e64d52a91c073bc2c7
https://doi.org/10.1080/105172398243023
https://doi.org/10.1080/105172398243023
Autor:
Janice R. Thornton-Manning, John A. Stephens, Kevin D. Rohrbacher, Alan R. Dahl, Per Gerde, Gary G. Scott
Publikováno v:
Toxicology Methods. 8:17-25
In experiments to determine the toxicokinetics of polycyclic aromatic hydrocarbons (PAHs) in lungs at environmentally realistic levels, a technique to measure metabolites in tissueat subfemtomolar concentrations was needed. Postexposure blood concent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37834a9e5467f705e25377c91becb88f
https://doi.org/10.1080/105172398243005
https://doi.org/10.1080/105172398243005
Autor:
Rogene F. Henderson, Alan R. Dahl, William C. Griffith, Janice R. Thornton-Manning, William E. Bechtold
Publikováno v:
Toxicology. 123:125-134
1,3-Butadiene (BD), a compound used extensively in the rubber industry, is a potent carcinogen in mice and a weak carcinogen in rats in chronic carcinogenicity bioassays. While many chemicals are known to alter their own metabolism after repeated exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7c389ebf8cd289274e2db9cfd247bbc
https://doi.org/10.1016/s0300-483x(97)00112-1
https://doi.org/10.1016/s0300-483x(97)00112-1
Publikováno v:
Toxicology. 113:17-22
Species differences in the metabolism of 1,3-butadiene (BD) have been studied in an effort to explain the major differences observed in the responses of mice, the sensitive species, and rats, the resistant species, to the toxicity of inhaled BD. BD i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e9ad9109ceafde9454f383a166ffaaf
https://doi.org/10.1016/0300-483x(96)03422-1
https://doi.org/10.1016/0300-483x(96)03422-1
Publikováno v:
Toxicology Letters. 78:1-7
Previous research has shown that i.p. injection of rats with pyridine results in a significant increase in immunoreactive renal cytochrome P4502E1 (alcohol-inducible form) in a dose- and time-dependent manner. However, the cellular location of renal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a0eda9ce6112bee0b2c0048ffcb1c93
https://doi.org/10.1016/0378-4274(94)03223-t
https://doi.org/10.1016/0378-4274(94)03223-t