Výsledky vyhledávání - "Alan R. Culwell"

Secreted Forms of β-Amyloid Precursor Protein Protect Against Ischemic Brain Injury

Autor: Susan D. Craddock, Russell E. Rydel, Virginia L. Smith-Swintosky, L. Creed Pettigrew, Mark P. Mattson, Alan R. Culwell

Publikováno v: Journal of Neurochemistry. 63:781-784

The beta-amyloid precursor protein (beta APP) is the source of the amyloid beta-peptide that accumulates in the brain in Alzheimer's disease. A major processing pathway for beta APP involves an enzymatic cleavage within the amyloid beta-peptide seque

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b1a8205dc25a4f2ce06b03679ac2dcc
https://doi.org/10.1046/j.1471-4159.1994.63020781.x

Zobrazit plný text záznamu

Sprouting and abnormal contacts of nonmedullated axons, and deposition of extracellular material induced by the amyloid precursor protein (APP) and other protease inhibitors

Autor: Alan R. Culwell, Jaime Alvarez, Nibaldo C. Inestrosa, Ricardo D. Moreno

Publikováno v: Brain Research. 718:13-24

We have reported that the local administration of serine protease inhibitors (amyloid precursor protein with the Kunitz insert (APP K + ), aprotinin, and Lupeptin) to the rat sciatic nerve determines a sprouting response of myelinated axons, prolifer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf1a657dfd9c8a7b046129e3fa5e3fe9
https://doi.org/10.1016/0006-8993(95)01555-8

Zobrazit plný text záznamu

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein

Autor: Frederick Esch, Mark P. Mattson, Alan R. Culwell, Bin Cheng, Russell E. Rydel, Ivan Lieberburg

Publikováno v: Neuron. 10(2)

The β-amyloid precursor protein (βAPP) is a membrane-spanning glycoprotein that is the source of the β-amyloid peptide (βAP) which accumulates as senile plaques in the brains of patients with Alzheimer's disease. βAPP is normally processed such

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d990541d509b46d3d086c0b6f20f62b4
https://pubmed.ncbi.nlm.nih.gov/8094963

Zobrazit plný text záznamu

Apolipoprotein E: phospholipid binding studies with synthetic peptides from the carboxyl terminus

Autor: Doris A. Sparrow, Merry Kovar, James T. Sparrow, Germain J. P. Fernando, Alan R. Culwell, Antonio M. Gotto

Publikováno v: Biochemistry. 31(4)

We have previously shown that the synthetic peptide apoE(129-169) forms lipid-peptide complexes with dimyristoylphosphatidylcholine (DMPC) with an L:P molar ratio of 125:1; the peptide in the isolated complex contains approximately 56% alpha-helicity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae4f3ad2f9e2a8d3da962d11baf68986
https://pubmed.ncbi.nlm.nih.gov/1734956

Zobrazit plný text záznamu

Cleavage of amyloid beta peptide during constitutive processing of its precursor

Autor: Russell W. Blacher, Donald McClure, Eric C. Beattie, Tilman Oltersdorf, Frederick Esch, Pamela S. Keim, Alan R. Culwell, Pamela J. Ward

Publikováno v: Science (New York, N.Y.). 248(4959)

The amyloid beta peptide (A beta P) is a small fragment of the much larger, broadly distributed amyloid precursor protein (APP). Abundant A beta P deposition in the brains of patients with Alzheimer's disease suggests that altered APP processing may

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61d919fa82f1eaa7e414e53db86a5011
https://pubmed.ncbi.nlm.nih.gov/2111583

Zobrazit plný text záznamu

Lipid binding by fragments of apolipoprotein C-III-1 obtained by thrombin cleavage

Autor: Antonio M. Gotto, Lee D. Blumenthal, Henry J. Pownall, James T. Sparrow, Alan R. Culwell, Fu Juan Hsu

Publikováno v: Biochemistry. 16:5427-5431

We have used thrombin to cleave apolipoprotein C-III-1 into two fragments constituting residues 1-40 (apoLP-C-III-A) and 41-79 (apoLP-C-III-B). The lipid binding properties of these fragments with dimyristoyl- and 1-palmitoyl-2-oleoylphosphatidylchol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e09ecc7db1b9616834448b9ad5f9ea9d
https://doi.org/10.1021/bi00644a004

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání