Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Alan R. Clarke"'
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-16 (2019)
Abstract Background Canonical WNT signalling plays a critical role in the regulation of ovarian development; mis-regulation of this key pathway in the adult ovary is associated with subfertility and tumourigenesis. The roles of Adenomatous polyposis
Externí odkaz:
https://doaj.org/article/a3dbe4dd62544d03a2a0e349a57e5ed3
Autor:
Cleberson J. S. Queiroz, Fei Song, Karen R. Reed, Nadeem Al-Khafaji, Alan R. Clarke, Dale Vimalachandran, Fabio Miyajima, D. Mark Pritchard, John R. Jenkins
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
IntroductionColorectal cancer (CRC) is the second leading cause of cancer death worldwide and most deaths result from metastases. We have analyzed animal models in which Apc, a gene that is frequently mutated during the early stages of colorectal car
Externí odkaz:
https://doaj.org/article/35cd54370d2640b987a79ac9f606cf31
Autor:
Boris Y. Shorning, Joanna Zabkiewicz, Afshan McCarthy, Helen B. Pearson, Douglas J. Winton, Owen J. Sansom, Alan Ashworth, Alan R. Clarke
Publikováno v:
PLoS ONE, Vol 4, Iss 2 (2009)
Externí odkaz:
https://doaj.org/article/f675ea212b284ada87576336cd403ade
Autor:
Luned M Badder, Andrew J Hollins, Bram Herpers, Kuan Yan, Kenneth B Ewan, Mairian Thomas, Jennifer R Shone, Delyth A Badder, Marc Naven, Kevin E Ashelford, Rachel Hargest, Alan R Clarke, Christina Esdar, Hans-Peter Buchstaller, J Mark Treherne, Sylvia Boj, Bahar Ramezanpour, Dirk Wienke, Leo S Price, Paul H Shaw, Trevor C Dale
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0235319 (2020)
Aberrant activation of the Wnt signalling pathway is required for tumour initiation and survival in the majority of colorectal cancers. The development of inhibitors of Wnt signalling has been the focus of multiple drug discovery programs targeting c
Externí odkaz:
https://doaj.org/article/7afb5fbeb60b440b90aba42a6bfd295c
Autor:
Boris Y Shorning, Joanna Zabkiewicz, Afshan McCarthy, Helen B Pearson, Douglas J Winton, Owen J Sansom, Alan Ashworth, Alan R Clarke
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0223041 (2019)
[This corrects the article DOI: 10.1371/journal.pone.0004264.].
Externí odkaz:
https://doaj.org/article/611a0bd1afd44e08942b9d3a05b51aed
Autor:
Lekha Dinesh Kumar, Alan R. Clarke, K. Swaminathan Iyer, Igor Luzinov, Anne Bourdoncle, Bogdan Zdyrko, Nicole M. Smith, Jedy Jose, Anant B. Patel, Liza E. Alexander, Rekha A. Nair, Meera Raja, Ganesh Mahidhara, Trevor Hay, Syed S. Beevi, Tristan D. Clemons, Vinod K. Verma, Naveen K. Tangudu
In this article, we report the development and preclinical validation of combinatorial therapy for treatment of cancers using RNA interference (RNAi). RNAi technology is an attractive approach to silence genes responsible for disease onset and progre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::254db200d7bf5335aaa6da40ed522e85
https://doi.org/10.1158/1535-7163.c.6537127.v1
https://doi.org/10.1158/1535-7163.c.6537127.v1
This file contains supplementary methods and figures describing tumour severity scoring and tumour area measurements in all three tumour model. Additionally, histological representation of cleaved caspase 3 and BrdU staining and western blots showing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6514ae70685cc344fff59feaa65e7d2c
https://doi.org/10.1158/1535-7163.22506492.v1
https://doi.org/10.1158/1535-7163.22506492.v1
Autor:
Lekha Dinesh Kumar, Alan R. Clarke, K. Swaminathan Iyer, Igor Luzinov, Anne Bourdoncle, Bogdan Zdyrko, Nicole M. Smith, Jedy Jose, Anant B. Patel, Liza E. Alexander, Rekha A. Nair, Meera Raja, Ganesh Mahidhara, Trevor Hay, Syed S. Beevi, Tristan D. Clemons, Vinod K. Verma, Naveen K. Tangudu
Supplementary Figure S3: Toxicity studies of the nanoparticle in different organs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fa07d4cec77a62ae610653b9cf4b4a8
https://doi.org/10.1158/1535-7163.22502584
https://doi.org/10.1158/1535-7163.22502584
Autor:
Lekha Dinesh Kumar, Alan R. Clarke, K. Swaminathan Iyer, Igor Luzinov, Anne Bourdoncle, Bogdan Zdyrko, Nicole M. Smith, Jedy Jose, Anant B. Patel, Liza E. Alexander, Rekha A. Nair, Meera Raja, Ganesh Mahidhara, Trevor Hay, Syed S. Beevi, Tristan D. Clemons, Vinod K. Verma, Naveen K. Tangudu
Supplementary Figure S2: Cytotoxicity assays on different cell lines. In vitro cytotoxicity assay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d85e7ac04fd421daabae1fa5784d262
https://doi.org/10.1158/1535-7163.22502587.v1
https://doi.org/10.1158/1535-7163.22502587.v1
Autor:
Lekha Dinesh Kumar, Alan R. Clarke, K. Swaminathan Iyer, Igor Luzinov, Anne Bourdoncle, Bogdan Zdyrko, Nicole M. Smith, Jedy Jose, Anant B. Patel, Liza E. Alexander, Rekha A. Nair, Meera Raja, Ganesh Mahidhara, Trevor Hay, Syed S. Beevi, Tristan D. Clemons, Vinod K. Verma, Naveen K. Tangudu
Supplementary Table S1: Forward and Reverse primers used for quantitative pcr analysis of various genes like c-Myc,p53,GAPDH,NONO and U6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c450a176cc2415546e3f3f4b75a455a
https://doi.org/10.1158/1535-7163.22502569.v1
https://doi.org/10.1158/1535-7163.22502569.v1