Zobrazeno 1 - 10
of 225
pro vyhledávání: '"Alan R. Burns"'
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 931 (2023)
High-fat/sucrose diet feeding in mice causes loss of corneal nerve function and impairs corneal wound healing. While changing to a diet with a low fat/sugar composition and enrichments in complex carbohydrates mitigates the reduction in nerve functio
Externí odkaz:
https://doaj.org/article/f7cba9a43f2143df9a4b49dc63d2e156
Publikováno v:
Nutrients, Vol 14, Iss 1, p 139 (2021)
Mice fed a high fat diet (HFD) ab libitum show corneal dysregulation, as evidenced by decreased sensitivity and impaired wound healing. Time-restricted (TR) feeding can effectively mitigate the cardiometabolic effects of an HFD. To determine if TR fe
Externí odkaz:
https://doaj.org/article/c38b5cc88d264edc949ffb1ae2a8f2f3
Autor:
An‐Sheng Lee, Yu‐Chen Wang, Shih‐Sheng Chang, Ping‐Hang Lo, Chia‐Ming Chang, Jonathan Lu, Alan R. Burns, Chu‐Huang Chen, Akemi Kakino, Tatsuya Sawamura, Kuan‐Cheng Chang
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 2 (2020)
Background The circulating level of soluble lectin‐like oxidized low‐density lipoprotein receptor‐1 (sLOX‐1) is a valuable biomarker of acute myocardial infarction (AMI). The most electronegative low‐density lipoprotein, L5, signals through
Externí odkaz:
https://doaj.org/article/44013547bc7c40719d7ef5246f0c2d19
Autor:
Angie De La Cruz, Aubrey Hargrave, Sri Magadi, Justin A. Courson, Paul T. Landry, Wanyu Zhang, Fong W. Lam, Monica A. Bray, C. Wayne Smith, Alan R. Burns, Rolando E. Rumbaut
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 14, p 7360 (2021)
Platelet extravasation during inflammation is under-appreciated. In wild-type (WT) mice, a central corneal epithelial abrasion initiates neutrophil (PMN) and platelet extravasation from peripheral limbal venules. The same injury in mice expressing lo
Externí odkaz:
https://doaj.org/article/2cde00bdcb1d4a738dfb7136dbba3f0e
Autor:
Eugene A. Osae, Tiffany Bullock, Madhavi Chintapalati, Susanne Brodesser, Samuel Hanlon, Rachel Redfern, Philipp Steven, C. Wayne Smith, Rolando E. Rumbaut, Alan R. Burns
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 22, p 8772 (2020)
Background: Dyslipidemia may be linked to meibomian gland dysfunction (MGD) and altered meibum lipid composition. The purpose was to determine if plasma and meibum cholesteryl esters (CE), triglycerides (TG), ceramides (Cer) and sphingomyelins (SM) c
Externí odkaz:
https://doaj.org/article/db70843af57d4f2b869decc05430bc09
Autor:
Papa K. Van Dyck, Natasha Hockaden, Emma C. Nelson, Alyssa R. Koch, Kamil L. Hester, Neil Pillai, Gabrielle C. Coffing, Alan R. Burns, Pascal J. Lafontant
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 7, Iss 4, p 41 (2020)
In the last two decades, the zebrafish has emerged as an important model species for heart regeneration studies. Various approaches to model loss of cardiac myocytes and myocardial infarction in the zebrafish have been devised, and have included rese
Externí odkaz:
https://doaj.org/article/8d0d8612c926490991912257cdf59ff2
Autor:
M. David Stewart, Suhujey Lopez, Harika Nagandla, Benjamin Soibam, Ashley Benham, Jasmine Nguyen, Nicolas Valenzuela, Harry J. Wu, Alan R. Burns, Tara L. Rasmussen, Haley O. Tucker, Robert J. Schwartz
Publikováno v:
Disease Models & Mechanisms, Vol 9, Iss 3, Pp 347-359 (2016)
The Smyd1 gene encodes a lysine methyltransferase specifically expressed in striated muscle. Because Smyd1-null mouse embryos die from heart malformation prior to formation of skeletal muscle, we developed a Smyd1 conditional-knockout allele to deter
Externí odkaz:
https://doaj.org/article/7624d789c2964ec3942e5143c4307fb0
Autor:
Eduardo I. Cardenas, Keegan Breaux, Qi Da, Jose R. Flores, Marco A. Ramos, Michael J. Tuvim, Alan R. Burns, Rolando E. Rumbaut, Roberto Adachi
Publikováno v:
Haematologica, Vol 103, Iss 7 (2018)
Platelet degranulation is crucial for hemostasis and may participate in inflammation. Exocytosis in platelets is mediated by SNARE proteins and should be controlled by Munc13 proteins. We found that platelets express Munc13-2 and -4. We assessed plat
Externí odkaz:
https://doaj.org/article/7bb1b5d4b2e5449f9426ef5f0712b170
Autor:
Eugene A. Osae, Philipp Steven, Rachel Redfern, Samuel Hanlon, C. Wayne Smith, Rolando E. Rumbaut, Alan R. Burns
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 14, p 3505 (2019)
Meibomian gland dysfunction (MGD) is the leading cause of dry eye disease and loss of ocular surface homeostasis. Increasingly, several observational clinical studies suggest that dyslipidemia (elevated blood cholesterol, triglyceride or lipoprotein
Externí odkaz:
https://doaj.org/article/082979fc54d8418f9a6411f91ec497f4
Autor:
Kasey C. Vickers, Colin T. Maguire, Robert Wolfert, Alan R. Burns, Michael Reardon, Richard Geis, Paul Holvoet, Joel D. Morrisett
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 9, Pp 1735-1743 (2009)
Plasma levels of lipoprotein-associated phospholipase A2 (Lp-PLA2) and oxidized low density lipoprotein (oxLDL) have been identified as risk factors for cardiovascular disease. Lp-PLA2 is the sole enzyme responsible for the hydrolysis of oxidized pho
Externí odkaz:
https://doaj.org/article/e10dd9be43fd4eb3935e724bc0d838a2