Zobrazeno 1 - 10
of 222
pro vyhledávání: '"Alan R Prescott"'
Autor:
Dipti Ranjan Lenka, Shakti Virendra Dahe, Odetta Antico, Pritiranjan Sahoo, Alan R Prescott, Miratul MK Muqit, Atul Kumar
Publikováno v:
eLife, Vol 13 (2024)
Loss-of-function Parkin mutations lead to early-onset of Parkinson’s disease. Parkin is an auto-inhibited ubiquitin E3 ligase activated by dual phosphorylation of its ubiquitin-like (Ubl) domain and ubiquitin by the PINK1 kinase. Herein, we demonst
Externí odkaz:
https://doaj.org/article/3f29e2a6e59d486a8abd2e720c70fea9
Autor:
Tsvetana Petrova, Kyle Bennett, Sambit Nanda, Sam Strickson, Cheryl L Scudamore, Alan R Prescott, Philip Cohen
Publikováno v:
PLoS ONE, Vol 17, Iss 2, p e0263151 (2022)
The expression of TNF-Receptor Associated Factor 6 (TRAF6) is essential for many physiological processes. Here we studied the phenotype of TRAF6[L74H] knock-in mice which are devoid of TRAF6 E3 ligase activity in every cell of the body, but express n
Externí odkaz:
https://doaj.org/article/5231f41ba28a4996abcc543715a58fad
Autor:
Francois Singh, Alan R Prescott, Philippa Rosewell, Graeme Ball, Alastair D Reith, Ian G Ganley
Publikováno v:
eLife, Vol 10 (2021)
Parkinson’s disease (PD) is a major and progressive neurodegenerative disorder, yet the biological mechanisms involved in its aetiology are poorly understood. Evidence links this disorder with mitochondrial dysfunction and/or impaired lysosomal deg
Externí odkaz:
https://doaj.org/article/1fe20ff9e4834b2f99a5c0d252b7aa97
Autor:
Maria Lucia Sampaio Guther, Alan R Prescott, Sabine Kuettel, Michele Tinti, Michael A J Ferguson
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 2, p e0009132 (2021)
In Trypanosoma brucei, there are fourteen enzymatic biotransformations that collectively convert glucose into five essential nucleotide sugars: UDP-Glc, UDP-Gal, UDP-GlcNAc, GDP-Man and GDP-Fuc. These biotransformations are catalyzed by thirteen disc
Externí odkaz:
https://doaj.org/article/a26f90bf8cc0433899cc58d86f6073bb
Autor:
Gerta Hoxhaj, Edward Caddye, Ayaz Najafov, Vanessa P Houde, Catherine Johnson, Kumara Dissanayake, Rachel Toth, David G Campbell, Alan R Prescott, Carol MacKintosh
Publikováno v:
eLife, Vol 5 (2016)
The mechanistic Target of Rapamycin complex 1 (mTORC1) senses intracellular amino acid levels through an intricate machinery, which includes the Rag GTPases, Ragulator and vacuolar ATPase (V-ATPase). The membrane-associated E3 ubiquitin ligase ZNRF2
Externí odkaz:
https://doaj.org/article/22e15996b1d34e3eb9da975e48348923
Autor:
Cristina Martin-Granados, Alan R Prescott, Nele Van Dessel, Aleyde Van Eynde, Miguel Arocena, Izabela P Klaska, Janina Görnemann, Monique Beullens, Mathieu Bollen, John V Forrester, Colin D McCaig
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40769 (2012)
Electrical gradients are present in many developing and regenerating tissues and around tumours. Mimicking endogenous electric fields in vitro has profound effects on the behaviour of many cell types. Intriguingly, specific cell types migrate cathoda
Externí odkaz:
https://doaj.org/article/53b1d6947e134e6aafbff575c15b6ec8
Autor:
Ana Paula F Trombone, Célio L Silva, Karla M Lima, Constance Oliver, Maria Célia Jamur, Alan R Prescott, Arlete A M Coelho-Castelo
Publikováno v:
PLoS ONE, Vol 2, Iss 9, p e923 (2007)
BACKGROUND: Experimental models using DNA vaccine has shown that this vaccine is efficient in generating humoral and cellular immune responses to a wide variety of DNA-derived antigens. Despite the progress in DNA vaccine development, the intracellul
Externí odkaz:
https://doaj.org/article/c0f1f578aa4f4ad08d77c6880a7843b6
Autor:
Selma Gulyurtlu, Monika S. Magon, Patrick Guest, Panagiotis P. Papavasiliou, Kim D. Morrison, Alan R. Prescott, Judith E. Sleeman
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 7 (2022)
RNA regulation in mammalian cells requires complex physical compartmentalisation, using structures thought to be formed by liquid-liquid phase separation. Disruption of these structures is implicated in numerous degenerative diseases. Myotonic dystro
Externí odkaz:
https://doaj.org/article/903258d2b7f94b81b35dc6b6d5b5fe78
Autor:
Alexia F Kalogeropulou, Elena Purlyte, Francesca Tonelli, Sven M Lange, Melanie Wightman, Alan R Prescott, Shalini Padmanabhan, Esther Sammler, Dario R Alessi
Publikováno v:
Biochemical Journal. 479:1759-1783
Mutations enhancing the kinase activity of LRRK2 cause Parkinson’s disease (PD) and therapies that reduce LRRK2 kinase activity are being tested in clinical trials. Numerous rare variants of unknown clinical significance have been reported, but how
Autor:
Gavuthami Murugesan, Alan R. Prescott, Rachel Toth, David G. Campbell, Claire M. Wells, Carol MacKintosh
Publikováno v:
Biochemical Journal. 479:1709-1725
The protein kinases PAK4, PAK5 and PAK6 comprise a family of ohnologues. In multiple cancers including melanomas PAK5 most frequently carries non-synonymous mutations; PAK6 and PAK4 have fewer; and PAK4 is often amplified. To help interpret these gen