A kinetic-based model of radiation-induced intercellular signalling.

Autor: Stephen J McMahon, Karl T Butterworth, Colman Trainor, Conor K McGarry, Joe M O'Sullivan, Giuseppe Schettino, Alan R Hounsell, Kevin M Prise

Publikováno v: PLoS ONE, Vol 8, Iss 1, p e54526 (2013)

It is now widely accepted that intercellular communication can cause significant variations in cellular responses to genotoxic stress. The radiation-induced bystander effect is a prime example of this effect, where cells shielded from radiation expos

Externí odkaz: https://doaj.org/article/894d4da32ca644499b419274edd390fc

Validation of a Quality Metric Score to Assess the Placement of Hydrogel Rectal Spacer in Patients Treated With Prostate Stereotactic Radiation Therapy

Autor: Valentina Giacometti, PhD, Owen McLaughlin, MSc, Patrick Comiskey, MSc, Hannah Marshall, MSc, Orla A. Houlihan, MB, BCh, BAO, Glenn Whitten, MSc, Kevin M. Prise, PhD, Alan R. Hounsell, PhD, Suneil Jain, MB, BCh, BAO, PhD, Conor K. McGarry, PhD

Publikováno v: Advances in Radiation Oncology, Vol 9, Iss 3, Pp 101396- (2024)

Purpose: To evaluate the quality of the interspace between the prostate and rectum and assess the effect on the dose to the rectum by measuring the spacer quality score (SQS) before and after implanting a hydrogel rectal spacer. Methods and Materials

Externí odkaz: https://doaj.org/article/95281abd405647738c50df6fdc9f9f11

Simultaneous integrated boost (SIB) to dominant intra-prostatic lesions during extreme hypofractionation for prostate cancer: the impact of rectal spacers

Autor: Sarah O. S. Osman, Ciaran Fairmichael, Glenn Whitten, Gavin S. Lundy, Rachel Wesselman, Melissa LaBonte Wilson, Alan R. Hounsell, Kevin M. Prise, Denise Irvine, Conor K. McGarry, Suneil Jain

Publikováno v: Radiation Oncology, Vol 17, Iss 1, Pp 1-10 (2022)

Abstract Purpose Boosting dominant intra-prostatic lesions (DILs) has the potential to increase the therapeutic ratio in prostate cancer radiotherapy. In this study, employing 5-fraction stereotactic ablative radiotherapy (SABR) volumetric modulated

Externí odkaz: https://doaj.org/article/11192b03d9494a15b23e8a2a8018700c

A pulmonary vein atlas for radiotherapy planning

Autor: Gerard M Walls, Conor McCann, Peter Ball, Katelyn M Atkins, Raymond H Mak, Ahmed Bedair, Jolyne O'Hare, Jonathan McAleese, Claire Harrison, Karen A Tumelty, Cathryn Crockett, Sarah-Louise Black, Catherine Nelson, John O'Connor, Alan R Hounsell, Conor K McGarry, Karl T Butterworth, Aidan J Cole, Suneil Jain, Gerard G Hanna

Publikováno v: Walls, G M, McCann, C, Ball, P, Atkins, K M, Mak, R H, Bedair, A, O'Hare, J, McAleese, J, Harrison, C, Tumelty, K A, Crockett, C, Black, S-L, Nelson, C, O'Connor, J, Hounsell, A R, McGarry, C K, Butterworth, K T, Cole, A J, Jain, S & Hanna, G G 2023, ' A pulmonary vein atlas for radiotherapy planning ', Radiotherapy and Oncology, vol. 184, 109680 . https://doi.org/10.1016/j.radonc.2023.109680

Background and PurposeCardiac arrhythmia is a recognised potential complication of thoracic radiotherapy, but the responsible cardiac substructures for arrhythmogenesis have not been identified. Arrhythmogenic tissue is commonly located in the pulmon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00e611912b78afe3389244dbd05479c1
https://pure.qub.ac.uk/en/publications/bac88175-6c5a-4b6e-9b20-2b9715659575

Supplementary figure SF4 from Toxicity and Efficacy of Concurrent Androgen Deprivation Therapy, Pelvic Radiotherapy, and Radium-223 in Patients with De Novo Metastatic Hormone-Sensitive Prostate Cancer

Autor: Joe M. O'Sullivan, Sandra Biggart, Conor K. McGarry, Alan R. Hounsell, Kevin M. Prise, Darren Mitchell, Arthur Grey, Aidan Cole, Suneil Jain, Philip G. Turner

Supplementary figure SF4 shows (A) Kaplan-Meier plot to estimate median progression free survival as time from first docetaxel (or trial registration if no docetaxel received) until PSA progression per PCWG. Median progression free survival = 20.5 mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dd778b7057e540b59dbae78c82834e9
https://doi.org/10.1158/1078-0432.22480730