Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Alan R Crossman"'
Autor:
Birger Scholz, Marcus Svensson, Henrik Alm, Karl Sköld, Maria Fälth, Kim Kultima, Céline Guigoni, Evelyne Doudnikoff, Qin Li, Alan R Crossman, Erwan Bezard, Per E Andrén
Publikováno v:
PLoS ONE, Vol 3, Iss 2, p e1589 (2008)
L-3,4-dihydroxypheylalanine (L-dopa)-induced dyskinesia represent a debilitating complication of therapy for Parkinson's disease (PD) that result from a progressive sensitization through repeated L-dopa exposures. The MPTP macaque model was used to s
Externí odkaz:
https://doaj.org/article/073d7fe810194b57805c4854dc0d06d7
Publikováno v:
Neurobiology of Disease, Vol 70, Iss , Pp 138-148 (2014)
Regulators of G-protein signalling (RGS) proteins are implicated in striatal G-protein coupled receptor (GPCR) sensitisation in the pathophysiology of l-DOPA-induced abnormal involuntary movements (AIMs), also known as dyskinesia (LID), in Parkinson'
Externí odkaz:
https://doaj.org/article/0eba9eb1536e4ed38ed0e101b9f9182e
Autor:
Mathieu Bourdenx, Anna Nilsson, Henrik Wadensten, Maria Fälth, Qin Li, Alan R. Crossman, Per E. Andrén, Erwan Bezard
Publikováno v:
Neurobiology of Disease, Vol 62, Iss , Pp 307-312 (2014)
A role for enhanced peptidergic transmission, either opioidergic or not, has been proposed for the generation of l-3,4-dihydroxyphenylalanine (l-DOPA)-induced dyskinesia (LID) on the basis of in situ hybridization studies showing that striatal peptid
Externí odkaz:
https://doaj.org/article/187cd486ff3f415d9b9d40f959ce3726
Autor:
Alan R. Crossman, Elsa Y. Pioli, Erwan Bezard, Anna Nilsson, Qin Li, Elva Fridjonsdottir, Heather Hulme, Per E. Andrén
Publikováno v:
J Neurosci
Parkinson's disease (PD) is characterized by severe locomotor deficits and is commonly treated with the dopamine precursor L-DOPA, but its prolonged usage causes dyskinesias referred to as L-DOPA–induced dyskinesia (LID). Several studies in animal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41dec1d8c7f727045897aaf315668b3d
https://doi.org/10.1523/jneurosci.0610-20.2020
https://doi.org/10.1523/jneurosci.0610-20.2020
Publikováno v:
Neurobiology of Disease, Vol 8, Iss 2, Pp 343-350 (2001)
GABA and enkephalin-utilizing efferents from the striatum to the external segment of the pallidal complex (GPe) are thought to be overactive in Parkinson's disease (PD). This overactivity is generally held to play a major role in the genesis of parki
Externí odkaz:
https://doaj.org/article/f9848cdaf54b4f4aaa8ba044ca88b541
Autor:
M. Angela Cenci, Alan R. Crossman
Publikováno v:
Movement Disorders. 33:889-899
Understanding the biological mechanisms of l-dopa-induced motor complications is dependent on our ability to investigate these phenomena in animal models of Parkinson's disease. The most common motor complications consist in wearing-off fluctuations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::380ecb2874b836b5b52cb2104e9b5c71
https://doi.org/10.1002/mds.27337
https://doi.org/10.1002/mds.27337
Autor:
M Angela, Cenci, Alan R, Crossman
Publikováno v:
Movement disorders : official journal of the Movement Disorder Society. 33(6)
Understanding the biological mechanisms of l-dopa-induced motor complications is dependent on our ability to investigate these phenomena in animal models of Parkinson's disease. The most common motor complications consist in wearing-off fluctuations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::69ac22f188e4f525670cd35113ff48d4
https://pubmed.ncbi.nlm.nih.gov/29488257
https://pubmed.ncbi.nlm.nih.gov/29488257
Publikováno v:
Neurobiology of Disease, Vol 70, Iss, Pp 138-148 (2014)
Regulators of G-protein signalling (RGS) proteins are implicated in striatal G-protein coupled receptor (GPCR) sensitisation in the pathophysiology of l-DOPA-induced abnormal involuntary movements (AIMs), also known as dyskinesia (LID), in Parkinson'
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::796bfe4759ec08b1368d085120eb7688
http://www.sciencedirect.com/science/article/pii/S0969996114001776
http://www.sciencedirect.com/science/article/pii/S0969996114001776
Autor:
Monty Silverdale, Alan R. Crossman, David J. Burn, Lewis Kass-Iliyya, Christopher Kobylecki, Mark Kellett
Publikováno v:
Parkinsonism & Related Disorders. 20:452-455
Background The antiepileptic drug topiramate reduces levodopa-induced dyskinesia without exacerbating parkinsonism in animal models. We report a randomized, double-blind, placebo-controlled crossover trial in patients with Parkinson's disease and lev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f8cadd6d841440bb6ce2f196adb8f39
https://doi.org/10.1016/j.parkreldis.2014.01.016
https://doi.org/10.1016/j.parkreldis.2014.01.016
Autor:
Qin Li, Maria Fälth, Mathieu Bourdenx, Henrik Wadensten, Erwan Bezard, Per E. Andrén, Alan R. Crossman, Anna Nilsson
Publikováno v:
Neurobiology of Disease, Vol 62, Iss, Pp 307-312 (2014)
A role for enhanced peptidergic transmission, either opioidergic or not, has been proposed for the generation of l-3,4-dihydroxyphenylalanine (l-DOPA)-induced dyskinesia (LID) on the basis of in situ hybridization studies showing that striatal peptid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::407874c259a8f561f0267936463603c5
https://doi.org/10.1016/j.nbd.2013.10.016
https://doi.org/10.1016/j.nbd.2013.10.016