Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Alan Peter Lewis"'
Autor:
Alan Peter Lewis, Alexander Bujotzek, Bruck Taddese, Guy Georges, Charlotte M. Deane, Wing Ki Wong, James Snowden, Jiye Shi, Sarah Robinson
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Solving the structure of an antibody-antigen complex gives atomic level information of the interactions between an antibody and its antigen, but such structures are expensive and hard to obtain. Alternative experimental sources include epitope mappin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1cf9fa7f50f05bd149c00516872b84d
https://doi.org/10.1080/19420862.2021.1873478
https://doi.org/10.1080/19420862.2021.1873478
Autor:
Matthew I. J. Raybould, Charlotte M. Deane, Aleksandr Kovaltsuk, Claire Marks, Jiye Shi, Alan Peter Lewis
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 17, Iss 3, p e1008781 (2021)
PLoS Computational Biology, Vol 17, Iss 3, p e1008781 (2021)
The naïve antibody/B-cell receptor (BCR) repertoires of different individuals ought to exhibit significant functional commonality, given that most pathogens trigger an effective antibody response to immunodominant epitopes. Sequence-based repertoire
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea49903aa2de3eb7077ac6c5e6f0c178
https://pubmed.ncbi.nlm.nih.gov/33647011
https://pubmed.ncbi.nlm.nih.gov/33647011
Autor:
Martin J. Scott, David Gower, Michael L Washburn, Katie Poulton, Alan Peter Lewis, Larissa Ouro-Gnao, Ruud de Wildt, Martin Anibal Orecchia, John Yates, Nick Barton, Carol A. Harris, Kathrine J. Smith, Julia Ticehurst, Michael J. Mullin, Peter Franz Ertl, Amanda Jowett
Publikováno v:
mAbs
Complex cellular targets such as G protein-coupled receptors (GPCRs), ion channels, and other multi-transmembrane proteins represent a significant challenge for therapeutic antibody discovery, primarily because of poor stability of the target protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97f40392ac54a6d941aeaab92117d5f5
http://europepmc.org/articles/PMC7188403
http://europepmc.org/articles/PMC7188403
Autor:
Jiye Shi, Alan Peter Lewis, Aleksandr Kovaltsuk, Claire Marks, Charlotte M. Deane, Matthew I. J. Raybould
The antibody repertoires of different individuals ought to exhibit significant functional commonality, given that most pathogens trigger a successful immune response in most people. Sequence-based approaches have so far offered little evidence for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b93fa10c2cc204c1a72380d5b1f7ce1
https://zenodo.org/record/4038102
https://zenodo.org/record/4038102
Publikováno v:
Bioinformatics. 36:3580-3581
Motivation T-cell receptors (TCRs) are immune proteins that primarily target peptide antigens presented by the major histocompatibility complex. They tend to have lower specificity and affinity than their antibody counterparts, and their binding site
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2f83a9676d22db6a64482088bd3fe2
https://doi.org/10.1093/bioinformatics/btaa194
https://doi.org/10.1093/bioinformatics/btaa194
Autor:
Alexander Bujotzek, Jaroslaw Nowak, Bruck Taddese, Charlotte M. Deane, Claire Marks, Jiye Shi, Alan Peter Lewis, Raybould Mij, Konrad Krawczyk
Therapeutic monoclonal antibodies (mAbs) must not only bind to their target but must also be free from 'developability issues', such as poor stability or high levels of aggregation. While small molecule drug discovery benefits from Lipinski's rule of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87c0ebd68101e5c3facbe7b804d95b8a
https://doi.org/10.1101/359141
https://doi.org/10.1101/359141
Publikováno v:
Biotechnology and bioengineering. 115(5)
Monoclonal antibodies of the IgG2 and IgG4 isotype were found to exhibit an increased propensity for displaying two-peak elution profiles during cation exchange chromatography. In some cases, this two-peak elution profile also resulted in the formati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4f2e24209c13c1cad75a7293336ff56
https://pubmed.ncbi.nlm.nih.gov/29315494
https://pubmed.ncbi.nlm.nih.gov/29315494
Autor:
John Tonkyn, Alan Peter Lewis, Joanna Cordy, Y. Chen, Andrew I. Bayliffe, Aili L. Lazaar, William Powley, Mary Birchler, Philippe Bareille, Peter J. Morley, Robyn Emmins, Tracey J. Wright, Robert Wilson
Publikováno v:
Clinical and experimental immunology. 182(2)
Summary During clinical trials of a tumour necrosis factor (TNF)-R1 domain antibody (dAb™) antagonist (GSK1995057), infusion reactions consistent with cytokine release were observed in healthy subjects with high levels of a novel, pre-existing huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2ca85a6b1dc4a6a9cac6dd540008463
https://pubmed.ncbi.nlm.nih.gov/26178412
https://pubmed.ncbi.nlm.nih.gov/26178412
Autor:
Adele Gibson, Karen Affleck, Alan Peter Lewis, Nicola Thompson, Alan J. Aitken, Eric Charles Meldrum
Publikováno v:
Journal of Biological Chemistry. 280:27205-27212
Proteins of the CLCA gene family have been proposed to mediate calcium-activated chloride currents. In this study, we used detailed bioinformatics analysis and found that no transmembrane domains are predicted in hCLCA1 or mCLCA3 (Gob-5). Further ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0728ecfcd1375922689436f3c356e69
https://doi.org/10.1074/jbc.m504654200
https://doi.org/10.1074/jbc.m504654200
Autor:
Pauline T. Lukey, Alan Peter Lewis, Chris Clayton, Iryna N. J. Andrade, Hazel M. Dockrell, Mark Lennon, Rohit Mistry, Jacqueline M. Cliff, Ken Duncan
Publikováno v:
The Journal of Immunology. 173:485-493
T cell activation in response to antigenic stimulation is a complex process, involving changes in the expression level of a large number of genes. We have used cDNA array technology to characterize the differences in gene expression between human CD4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4885e3d27e95886f6fb00480019f6aa
https://doi.org/10.4049/jimmunol.173.1.485
https://doi.org/10.4049/jimmunol.173.1.485