Disposal of iron by a mutant form of lipocalin 2

Autor: Jonathan Barasch, Maria Hollmen, Rong Deng, Eldad A. Hod, Peter B. Rupert, Rebecca J. Abergel, Benjamin E. Allred, Katherine Xu, Shaun F. Darrah, Yared Tekabe, Alan Perlstein, Rebecca Wax, Efrat Bruck, Jacob Stauber, Kaitlyn A. Corbin, Charles Buchen, Vesna Slavkovich, Joseph Graziano, Steven L. Spitalnik, Guanhu Bao, Roland K. Strong, Andong Qiu

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)

Iron overload can be either hereditary or acquired via transfusions, and current treatments include the use of iron chelators that have adverse effects in some patients. Here the authors modify siderocalin to enhance iron excretion in urine, and demo

Externí odkaz: https://doaj.org/article/3ae332e27072492dad5e0ff733401a56

Disposal of iron by a mutant form of lipocalin 2

Autor: Rong Deng, Rebecca Wax, Jacob Stauber, Shaun F. Darrah, Jonathan Barasch, Roland K. Strong, Peter B. Rupert, Joseph H. Graziano, Andong Qiu, Steven L. Spitalnik, Benjamin E. Allred, Alan Perlstein, Efrat Bruck, Yared Tekabe, Charles Buchen, Guan-Hu Bao, Katherine Xu, Rebecca J. Abergel, Kaitlyn A. Corbin, Maria Hollmen, Vesna Slavkovich, Eldad A. Hod

Publikováno v: Nature communications, vol 7, iss 1
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Nature Communications
Barasch, J; Hollmen, M; Deng, R; Hod, EA; Rupert, PB; Abergel, RJ; et al.(2016). Disposal of iron by a mutant form of lipocalin 2. Nature Communications, 7. doi: 10.1038/ncomms12973. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/2m1415r6

Iron overload damages many organs. Unfortunately, therapeutic iron chelators also have undesired toxicity and may deliver iron to microbes. Here we show that a mutant form (K3Cys) of endogenous lipocalin 2 (LCN2) is filtered by the kidney but can byp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e359224f2aacd2b444b1c02bbe556f02
https://doi.org/10.1038/ncomms12973