Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Alan P. Watt"'
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Treatments to limit T cell activation are essential for managing autoimmune and inflammatory disorders. The B subunit of Escherichia coli heat-labile enterotoxin (EtxB) is known to ameliorate inflammatory disease in vivo but the mechanism by which th
Externí odkaz:
https://doaj.org/article/42c7003875334038917951b84ae4fe61
Autor:
David Harrison, Mark G. Bock, John R. Doedens, Christopher A. Gabel, M. Katharine Holloway, Arwel Lewis, Jane Scanlon, Andrew Sharpe, Iain D. Simpson, Pamela Smolak, Grant Wishart, Alan P. Watt
Publikováno v:
ACS Medicinal Chemistry Letters. 13:1321-1328
The NLRP3 inflammasome is a multiprotein complex that facilitates activation and release of the proinflammatory cytokines interleukin-1β (IL-1β) and IL-18 in response to infection or endogenous stimuli. It can be inappropriately activated by a rang
Autor:
Krzysztof Brzózka, Alan P. Watt, Michal Galezowski, Magdalena Mroczkowska, Stefan Chmielewski, Grzegorz Witold Topolnicki, Christopher A. Gabel, David J. Schultz, John R. Doedens, Charles-Henry Fabritius, Oleksandr Levenets, Piotr Kowalczyk, Piotr Urbanski, Katarzyna Palica, Nicolas Boutard, Anna Cierpich, Roderick A. Porter, Marta Bugaj, Jakub Woyciechowski, Marta Sowinska, David G. Harrison
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(23)
The NLRP3 inflammasome is a component of the innate immune system involved in the production of proinflammatory cytokines. Aberrant activation by a wide range of exogenous and endogenous signals can lead to chronic, low-grade inflammation. It has att
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 8 (2017)
Frontiers in Immunology, Vol 8 (2017)
Treatments to limit T cell activation are essential for managing autoimmune and inflammatory disorders. The B subunit of Escherichia coli heat-labile enterotoxin (EtxB) is known to ameliorate inflammatory disease in vivo but the mechanism by which th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87fec12720f683cb3f80691341ef5277
Autor:
Gavin Bennett, Anne J. Rüger, John Thomas Feutrill, Rosemary Lynch, Ann Lewis, Anthea L. Newton, Nico Zinn, Tammy Ladduwahetty, Sunose Mihiro, Andrew Cansfield, Giovanna Bergamini, Oliver Rausch, Alan P. Watt, Douglas W. Thomson, Katie Ellard
Publikováno v:
ACS Medicinal Chemistry Letters. 7:768-773
CZ415, a potent ATP-competitive mTOR inhibitor with unprecedented selectivity over any other kinase is described. In addition to a comprehensive characterization of its activities in vitro, in vitro ADME, and in vivo pharmacokinetic data are reported
Autor:
Duane B. Snavely, Alan P. Watt, Xiaojing J. Wang, Lenard A. Adler, Pete H. Hutson, Robert C. Alexander, Thomas Rosah, Frederick W. Reimherr, Jennifer Knighton, Anna Rivkin
Publikováno v:
Journal of Attention Disorders. 16:664-674
Objective: Preclinical models, receptor localization, and genetic linkage data support the role of D4 receptors in the etiology of ADHD. This proof-of-concept study was designed to evaluate MK-0929, a selective D4 receptor antagonist as treatment for
Autor:
Alan P. Watt
Publikováno v:
Hit and Lead Profiling: Identification and Optimization of Drug-like Molecules, Volume 43
Publikováno v:
Chemical Research in Toxicology. 17:3-16
It is generally accepted that there is neither a well-defined nor a consistent link between the formation of drug-protein adducts and organ toxicity. Because the potential does exist, however, for these processes to be causally related, the general s
Publikováno v:
Journal of Biochemical and Biophysical Methods. 54:275-286
The enantiomeric separation of a series of 2-arylindoles, developed as 5HT 2A receptor antagonists for the treatment of schizophrenia, was investigated. Evaluation of a number of chiral stationary phases (CSPs) suggested that Chiralcel OD-H and Chira
Publikováno v:
Analytical Chemistry. 74:1896-1902
A four-channel multiplexed electrospray inlet system (MUX) coupled to a triple quadrupole mass spectrometer was investigated as a higher throughput approach to quantitative analysis. Four discrete samples may be simultaneously analyzed by virtue of a