Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Alan P. Kaplan"'
Autor:
Duy Duong-Tran, Nghi Nguyen, Shizhuo Mu, Jiong Chen, Jingxuan Bao, Frederick H. Xu, Sumita Garai, Jose Cadena-Pico, Alan David Kaplan, Tianlong Chen, Yize Zhao, Li Shen, Joaquín Goñi
Publikováno v:
Mathematics, Vol 12, Iss 19, p 2967 (2024)
In systems and network neuroscience, many common practices in brain connectomic analysis are often not properly scrutinized. One such practice is mapping a predetermined set of sub-circuits, like functional networks (FNs), onto subjects’ functional
Externí odkaz:
https://doaj.org/article/d876363623f847cebdf3c340f3893d1f
Autor:
Kausar Abbas, Mintao Liu, Michael Wang, Duy Duong-Tran, Uttara Tipnis, Enrico Amico, Alan D. Kaplan, Mario Dzemidzic, David Kareken, Beau M. Ances, Jaroslaw Harezlak, Joaquín Goñi
Publikováno v:
iScience, Vol 26, Iss 9, Pp 107624- (2023)
Summary: Functional connectomes (FCs) containing pairwise estimations of functional couplings between pairs of brain regions are commonly represented by correlation matrices. As symmetric positive definite matrices, FCs can be transformed via tangent
Externí odkaz:
https://doaj.org/article/065fcd32b29f4483b3371d4d4db0fe72
Publikováno v:
APL Energy, Vol 1, Iss 1, Pp 010901-010901-5 (2023)
Perovskite CsPbI3 is a promising photovoltaic absorber material, thanks to its ideal bandgap for Si-tandem solar cell applications and its excellent thermochemical stability compared with hybrid organic–inorganic perovskites. However, CsPbI3 has it
Externí odkaz:
https://doaj.org/article/57d7b3ac9f0142adbe3f7781a7b5f464
Autor:
Duy Duong-Tran, Ralph Kaufmann, Jiong Chen, Xuan Wang, Sumita Garai, Frederick H. Xu, Jingxuan Bao, Enrico Amico, Alan D. Kaplan, Giovanni Petri, Joaquin Goni, Yize Zhao, Li Shen
Publikováno v:
Mathematics, Vol 12, Iss 3, p 455 (2024)
Human whole-brain functional connectivity networks have been shown to exhibit both local/quasilocal (e.g., a set of functional sub-circuits induced by node or edge attributes) and non-local (e.g., higher-order functional coordination patterns) proper
Externí odkaz:
https://doaj.org/article/25a914340ab04742adde15cef79ce56c
Autor:
Alan G. Kaplan
Publikováno v:
Pulmonary Therapy, Vol 5, Iss 1, Pp 11-21 (2019)
Abstract Chronic cough is common and impactful, frustrating both patients and clinicians. An empirical trial of therapy is often done with inhaled corticosteroids, but this practice should be replaced with attempting to make an accurate diagnosis. Th
Externí odkaz:
https://doaj.org/article/20f9f048f18b4085b76750a0000302de
Autor:
Zhan Ye, Amanda A Gorman, Annette M Uittenbogaard, Tanya Myers-Morales, Alan M Kaplan, Donald A Cohen, Susan C Straley
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e110956 (2014)
The virulence protein YopM of the plague bacterium Yersinia pestis has different dominant effects in liver and spleen. Previous studies focused on spleen, where YopM inhibits accumulation of inflammatory dendritic cells. In the present study we focus
Externí odkaz:
https://doaj.org/article/0cd27ae7bd4947d792edf4b54f9405de
Autor:
Annette M. Uittenbogaard, R. Lakshman Chelvarajan, Tanya eMyers-Morales, Amanda A. Gorman, W. June Brickey, Zhan eYe, Alan M. Kaplan, Donald A. Cohen, Jenny P.-Y. Ting, Susan C. Straley
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 2 (2012)
YopM is one of the six effector Yops of the human-pathogenic Yersinia, but its mechanism has not been defined. After delivery to J774A.1 monocyte-like cells, YopM can rapidly bind and activate the serine/threonine kinases RSK1 and PRK2. However, in i
Externí odkaz:
https://doaj.org/article/137463cd821e4008999c8df2193823b3
Autor:
Kiev S. Ly, Andrew Richard Hudson, Christine Hoffmaster, James T. Limberis, J. Guy Breitenbucher, Richard Barido, De Michael Chung, Yingzhuo Yan, Gary Anderson, Vincent J. Santora, Dany Gitnick, Dong Lee, Brett C. Bookser, Anne Danks, Robert E. Petroski, Graeme Freestone, Varsha Gupta, Clifford Cabebe, Andrew Morse, Michael R. Kennedy, Kristen Sebring, Zachary W. Yoder, Douglas Zook, Marco Peters, Chih-Kun Chai, Joel Renick, Jim Na, Theresa A. Almos, Shouzhen Xia, Ali Tabatabaei, John Nikpur, Samantha Sevidal, Stephine Chow, Mi Chen, Jillian Basinger, Chris L. Bellows, Lindsay Heger, David Neul, Jenny Wen, Brittany Masatsugu, Nicola J. Broadbent, Alan P. Kaplan, Chi Ching Mak
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(14)
A strategy to conformationally restrain a series of GlyT1 inhibitors identified potent analogs that exhibited slowly interconverting rotational isomers. Further studies to address this concern led to a series of azetidine-based inhibitors. Compound 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::912579fcc2f963bd82182bdd275301b0
https://pubmed.ncbi.nlm.nih.gov/32527538
https://pubmed.ncbi.nlm.nih.gov/32527538
Autor:
David Neul, Andrew Morse, Joel Renick, Brittany Masatsugu, Chi Ching Mak, James T. Limberis, Dany Gitnick, Zachary W. Yoder, Michael R. Kennedy, Kiev S. Ly, Samantha Sevidal, Richard Barido, Robert E. Petroski, Graeme Freestone, Clifford Cabebe, Jillian Basinger, Vincent J. Santora, Christine Hoffmaster, Chris L. Bellows, Yingzhuo Yan, Mi Chen, De Michael Chung, John Nikpur, Kristen Sebring, Jenny Wen, Ali Tabatabaei, Brett C. Bookser, Theresa A. Almos, Andrew Richard Hudson, J. Guy Breitenbucher, Chih-Kun Chai, Dong Lee, Lindsay Crickard, Anne Danks, Varsha Gupta, Marco Peters, Alan P. Kaplan, Jim Na, Nicola J. Broadbent, Stephine Chow, Douglas Zook
Publikováno v:
Journal of Medicinal Chemistry. 61:6018-6033
We report here the identification and optimization of a novel series of potent GlyT1 inhibitors. A ligand design campaign that utilized known GlyT1 inhibitors as starting points led to the identification of a novel series of pyrrolo[3,4- c]pyrazoles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3769bd94e72c5343ca6a4bb3a9739f64
https://doi.org/10.1021/acs.jmedchem.8b00372
https://doi.org/10.1021/acs.jmedchem.8b00372
Autor:
Andrew J. Mcriner, Xianbo Zhou, Mark E. Wilson, Dong Lee, Roderick E.M. Scott, Gary Anderson, Matthew Bletsch, John Nikpur, Rusiko Bourchouladze, Jennifer Stanley, Terence P. Keenan, Alan P. Kaplan, Regina Miller, Darlene Romashko, Adia Zhang
Publikováno v:
ACS chemical neuroscience. 8(12)
Initial work in Drosophila and mice demonstrated that the transcription factor cyclic adenosine monophosphate (cAMP) response element binding protein (CREB) is a master control gene for memory formation. The relationship between CREB and memory has a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f7b476ea0c941ce74c09b616a304f20
https://pubmed.ncbi.nlm.nih.gov/28857544
https://pubmed.ncbi.nlm.nih.gov/28857544