Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Alan P, Benson"'
Autor:
Michael A. Colman, Alan P. Benson
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Remodelling of cardiac tissue structure, including intercellular electrical coupling, is a major determinant of the complex and heterogeneous excitation patterns associated with cardiac arrhythmias. Evaluation of the precise mechanisms by wh
Externí odkaz:
https://doaj.org/article/29f483d081134c3291d27dbf556cf9ac
Autor:
Luke A. Howlett, Harley Stevenson‐Cocks, Michael A. Colman, Matthew K. Lancaster, Alan P. Benson
Publikováno v:
Physiological Reports, Vol 11, Iss 14, Pp n/a-n/a (2023)
Abstract This study aimed to simulate ventricular responses to elevations in myocyte pacing and adrenergic stimulation using a novel electrophysiological rat model and investigate ion channel responses underlying action potential (AP) modulations. Pe
Externí odkaz:
https://doaj.org/article/f5a475f73fc043af8fb9a126b6375b73
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Chronic exposure to low levels of Carbon Monoxide is associated with an increased risk of cardiac arrhythmia. Microelectrode recordings from rat and guinea pig single isolated ventricular myocytes exposed to CO releasing molecule CORM-2 and excited a
Externí odkaz:
https://doaj.org/article/95baf7e0368f4c62809bfc9208b95fb0
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Background: Non-invasive cardiac mapping—also known as Electrocardiographic imaging (ECGi)—is a novel, painless and relatively economic method to map the electrical activation and repolarization patterns of the heart, providing a valuable tool fo
Externí odkaz:
https://doaj.org/article/9e992db8fb9b4e99b9833102faa968e7
Autor:
Michael A Colman, Alan P Benson
Remodelling of cardiac tissue structure, including intercellular electrical coupling, is a major determinant of the complex and heterogeneous excitation patterns associated with cardiac arrhythmias. Evaluation of the precise mechanisms by which local
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b34aa8d5bd9fbf7616a7ade5283abbee
https://doi.org/10.1101/2022.11.11.516084
https://doi.org/10.1101/2022.11.11.516084
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
The short QT syndrome (SQTS) is a rare cardiac disorder associated with arrhythmias and sudden death. Gain-of-function mutations to potassium channels mediating the rapid delayed rectifier current, IKr, underlie SQTS variant 1 (SQT1), in which treatm
Externí odkaz:
https://doaj.org/article/eefabde0f55c4c9a993540dea2eff325
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
Background: Prolongation of the QT interval of the electrocardiogram (ECG), underlain by prolongation of the action potential duration (APD) at the cellular level, is linked to increased vulnerability to cardiac arrhythmia. Pharmacological management
Externí odkaz:
https://doaj.org/article/662ef31147c64baf914f32c0648ceafc
Autor:
Graham N. Askew, T. Scott Bowen, Peter G. Tickle, Roger W. P. Kissane, Ever Espino-Gonzalez, Stuart Egginton, Alan P. Benson
Publikováno v:
JOURNAL OF PHYSIOLOGY-LONDON
KEY POINTS Heart failure is characterised by limb and respiratory muscle impairments that limit functional capacity and quality of life. However, compared with heart failure with reduced ejection fraction (HFrEF), skeletal muscle alterations induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad35d297215bb950763e1a50668c0313
https://doi.org/10.1113/jp280899
https://doi.org/10.1113/jp280899
Publikováno v:
Methods. 185:60-81
Computational models of the heart, from cell-level models, through one-, two- and three-dimensional tissue-level simplifications, to biophysically-detailed three-dimensional models of the ventricles, atria or whole heart, allow the simulation of exci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b03dd5a8c66adea2549cb9515cccfba
https://doi.org/10.1016/j.ymeth.2020.01.010
https://doi.org/10.1016/j.ymeth.2020.01.010
Autor:
Harry B. Rossiter, Karen M. Birch, Carrie Ferguson, Daniel T. Cannon, Matthew J. Davies, Gemma K. Lyall, Alan P. Benson
Publikováno v:
Medicine and science in sports and exercise. 53(8)
The mechanism(s) of exercise intolerance at V˙O2max remain poorly understood. In health, standard ramp-incremental (RI) exercise is limited by fatigue-induced reductions in maximum voluntary cycling power. Whether neuromuscular fatigue also limits e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::503b56905c0ea8199155b51017979549
https://pubmed.ncbi.nlm.nih.gov/34261991
https://pubmed.ncbi.nlm.nih.gov/34261991