Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Alan N. Bateson"'
Autor:
Philip M. Hopkins, Fanning Zeng, Alexandra M. Dedman, Carol J. Milligan, Alan N. Bateson, Yahya M Bahnasi, David J. Beech, H M Wright
Publikováno v:
British Journal of Pharmacology. 153:1505-1512
Background and purpose: TRPC5 is a mammalian homologue of the Drosophila Transient Receptor Potential (TRP) channel and has expression and functions in the cardiovascular and nervous systems. It forms a calcium-permeable cation channel that can be ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1be68f170ebb6d7a00d59fa1347e5fa
https://doi.org/10.1038/sj.bjp.0707689
https://doi.org/10.1038/sj.bjp.0707689
Autor:
Alan N. Bateson
Publikováno v:
Sleep Medicine. 7:S3-S9
The benzodiazepine binding site on the GABA A receptor is the target for the majority of hypnotics, including the nonbenzodiazepine ‘Z drugs' (zaleplon, zolpidem, zopiclone and eszopiclone). Concerns still exist over long-term benzodiazepine use, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14345792972b9e325fd1eea829934545
https://doi.org/10.1016/j.sleep.2006.03.001
https://doi.org/10.1016/j.sleep.2006.03.001
A Sphingosine-1–Phosphate-Activated Calcium Channel Controlling Vascular Smooth Muscle Cell Motility
Autor:
Alexandra M. Dedman, Alex Cheong, Damian McHugh, Samir S. Shah, Karen E. Porter, Katsuhiko Muraki, David J. Beech, Alan N. Bateson, Piruthivi Sukumar, Jacqueline Naylor, Jing Li, Fanning Zeng, Philippa K. Flemming, Shang-Zhong Xu, Christopher M. Munsch
Publikováno v:
Circulation Research. 98:1381-1389
In a screen of potential lipid regulators of transient receptor potential (TRP) channels, we identified sphingosine-1–phosphate (S1P) as an activator of TRPC5. We explored the relevance to vascular biology because S1P is a key cardiovascular signal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88d4d5c8dafed754033187cc2af34d5f
https://doi.org/10.1161/01.res.0000225284.36490.a2
https://doi.org/10.1161/01.res.0000225284.36490.a2
Autor:
Alexandra M. Dedman, Fanning Zeng, Shang-Zhong Xu, David J. Beech, Jing Li, Philippa K. Flemming, Jacqueline Naylor, Katsuhiko Muraki, Alan N. Bateson, Christopher D. Benham
Publikováno v:
Journal of Biological Chemistry. 281:4977-4982
TRPC calcium channels are emerging as a ubiquitous feature of vertebrate cells, but understanding of them is hampered by limited knowledge of the mechanisms of activation and identity of endogenous regulators. We have revealed that one of the TRPC ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6e012568e03cc661169c98d72a8b240
https://doi.org/10.1074/jbc.m510301200
https://doi.org/10.1074/jbc.m510301200
Autor:
Alan N. Bateson
Publikováno v:
Sleep Medicine. 5:S9-S15
The gamma-aminobutyric acid-A (GABA(A)) receptors is the target for the most widely prescribed sleep medicines. It is a ligand-gated ion channel, activated by the amino acid neurotransmitter GABA, which normally results in hyperpolarization of neuron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02bdfb41c5227848bd504c4db8505fbe
https://doi.org/10.1016/s1389-9457(04)90002-0
https://doi.org/10.1016/s1389-9457(04)90002-0
Autor:
Chris Peers, Michael L.J. Ashford, Stephen Paul Brazier, Alan N. Bateson, Matthew E. Hartness, Paul J. Kemp
Publikováno v:
Journal of Biological Chemistry. 278:51422-51432
Various cardiorespiratory diseases (e.g. congestive heart failure, emphysema) result in systemic hypoxia and patients consequently demonstrate adaptive cellular responses which predispose them to conditions such as pulmonary hypertension and stroke.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bead42b53786ee04bc84b7231d2c96e
https://doi.org/10.1074/jbc.m309463200
https://doi.org/10.1074/jbc.m309463200
Publikováno v:
Journal of Neurochemistry. 70:2188-2194
His101 of the GABA(A) receptor alpha1 subunit is an important determinant of benzodiazepine recognition and a major site of photolabeling by [3H]flunitrazepam. To investigate further the chemical specificity of the residue in this position, we substi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c24fd5e89a78f5f60cf38141b57c8f68
https://doi.org/10.1046/j.1471-4159.1998.70052188.x
https://doi.org/10.1046/j.1471-4159.1998.70052188.x
Publikováno v:
Molecular Biotechnology. 14:25-46
Receptor-ligand interactions have traditionally been evaluated using a number of biochemical techniques including radioligand binding, photoaffinity labeling, crosslinking, and chemical modification. In modern biochemistry, these approaches have larg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55e17e77c0e48dae844e8aeea53f7796
https://doi.org/10.1385/mb:14:1:25
https://doi.org/10.1385/mb:14:1:25
Autor:
Sandra E. File, Michelle I. Arnot, Alan N. Bateson, Cathy Fernandes, Elaine E. Irvine, Ian L. Martin
Publikováno v:
Psychopharmacology. 145:251-259
Rationale: Chronic treatment with benzodiazepines results in tolerance to their sedative and anxiolytic effects and there is considerable evidence that different mechanisms underlie the development of tolerance to different behavioural effects. Objec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd31d981b21d1ba87240e2333d1911bc
https://doi.org/10.1007/s002130051056
https://doi.org/10.1007/s002130051056
Autor:
Gregory J.R. Charrois, Chien-Tsai Lai, Glen B. Baker, Alan N. Bateson, Véronique A.-M. I. Tanay
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 357:32-38
There is an increasing body of evidence suggesting that GABA plays an important role in the therapeutic effects of antidepressant/antipanic drugs. Phenelzine and imipramine are efficacious in the treatment of depression and panic disorder and phenelz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a1deaa2a5f4e7d3980598f47e5251f1
https://doi.org/10.1007/pl00005135
https://doi.org/10.1007/pl00005135