Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Alan N Engelman"'
Autor:
Ashwanth C Francis, Anna Cereseto, Parmit K Singh, Jiong Shi, Eric Poeschla, Alan N Engelman, Christopher Aiken, Gregory B Melikyan
Publikováno v:
PLoS Pathogens, Vol 18, Iss 8, p e1010754 (2022)
In infectious HIV-1 particles, the capsid protein (CA) forms a cone-shaped shell called the capsid, which encases the viral ribonucleoprotein complex (vRNP). Following cellular entry, the capsid is disassembled through a poorly understood process ref
Externí odkaz:
https://doaj.org/article/166d03dde2f742408db1c08163d5768e
Autor:
Tatsuya Maehigashi, Seohyun Ahn, Uk-Il Kim, Jared Lindenberger, Adrian Oo, Pratibha C Koneru, Bijan Mahboubi, Alan N Engelman, Mamuka Kvaratskhelia, Kyungjin Kim, Baek Kim
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009671 (2021)
Allosteric integrase inhibitors (ALLINIs) are a class of experimental anti-HIV agents that target the noncatalytic sites of the viral integrase (IN) and interfere with the IN-viral RNA interaction during viral maturation. Here, we report a highly pot
Externí odkaz:
https://doaj.org/article/08f9da231eaa4056b8d8eda2abea8078
Autor:
Gregory J Bedwell, Alan N Engelman
Publikováno v:
eLife, Vol 10 (2021)
High-resolution imaging techniques reveal new insights into the actions of the retrovirus HIV-1 inside host cells.
Externí odkaz:
https://doaj.org/article/4c1d1457dc4f4e139161bfa132be5f39
Autor:
Chaoyi Xu, Douglas K Fischer, Sanela Rankovic, Wen Li, Robert A Dick, Brent Runge, Roman Zadorozhnyi, Jinwoo Ahn, Christopher Aiken, Tatyana Polenova, Alan N Engelman, Zandrea Ambrose, Itay Rousso, Juan R Perilla
Publikováno v:
PLoS Biology, Vol 18, Iss 12, p e3001015 (2020)
Reverse transcription, an essential event in the HIV-1 life cycle, requires deoxynucleotide triphosphates (dNTPs) to fuel DNA synthesis, thus requiring penetration of dNTPs into the viral capsid. The central cavity of the capsid protein (CA) hexamer
Externí odkaz:
https://doaj.org/article/1aa20b004af54e01aac2ef7867b6cf2f
Autor:
Jennifer L Elliott, Jenna E Eschbach, Pratibha C Koneru, Wen Li, Maritza Puray-Chavez, Dana Townsend, Dana Q Lawson, Alan N Engelman, Mamuka Kvaratskhelia, Sebla B Kutluay
Publikováno v:
eLife, Vol 9 (2020)
A large number of human immunodeficiency virus 1 (HIV-1) integrase (IN) alterations, referred to as class II substitutions, exhibit pleiotropic effects during virus replication. However, the underlying mechanism for the class II phenotype is not know
Externí odkaz:
https://doaj.org/article/fc785895057f4094b8a248a31422ab37
Autor:
Lorenz Loyola, Vasudevan Achuthan, Kathryn Gilroy, Gillian Borland, Anna Kilbey, Nancy Mackay, Margaret Bell, Jodie Hay, Sriram Aiyer, Dylan Fingerman, Rodrigo A Villanueva, Ewan Cameron, Christine A Kozak, Alan N Engelman, James Neil, Monica J Roth
Publikováno v:
PLoS Pathogens, Vol 15, Iss 12, p e1008154 (2019)
Murine leukemia virus (MLV) integrase (IN) lacking the C-terminal tail peptide (TP) loses its interaction with the host bromodomain and extraterminal (BET) proteins and displays decreased integration at promoter/enhancers and transcriptional start si
Externí odkaz:
https://doaj.org/article/91ca4810555048f5889c474b6985f372
HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors
Autor:
Pratibha C Koneru, Ashwanth C Francis, Nanjie Deng, Stephanie V Rebensburg, Ashley C Hoyte, Jared Lindenberger, Daniel Adu-Ampratwum, Ross C Larue, Michael F Wempe, Alan N Engelman, Dmitry Lyumkis, James R Fuchs, Ronald M Levy, Gregory B Melikyan, Mamuka Kvaratskhelia
Publikováno v:
eLife, Vol 8 (2019)
Allosteric HIV-1 integrase (IN) inhibitors (ALLINIs) are a promising new class of antiretroviral agents that disrupt proper viral maturation by inducing hyper-multimerization of IN. Here we show that lead pyridine-based ALLINI KF116 exhibits striking
Externí odkaz:
https://doaj.org/article/f3f96045b25c4b55a0b26306772c43fd
Autor:
Irena Zurnic, Sylvia Hütter, Ute Rzeha, Roger Helbig, Nicole Stanke, Juliane Reh, Erik Müllers, Martin V Hamann, Tobias Kern, Gesche K Gerresheim, Fabian Lindel, Erik Serrao, Paul Lesbats, Alan N Engelman, Peter Cherepanov, Dirk Lindemann
Publikováno v:
PLoS Pathogens, Vol 12, Iss 10, p e1005956 (2016)
[This corrects the article DOI: 10.1371/journal.ppat.1005860.].
Externí odkaz:
https://doaj.org/article/36bed3f647a84e079e25a02dad907282
Autor:
Irena Zurnic, Sylvia Hütter, Ute Rzeha, Nicole Stanke, Juliane Reh, Erik Müllers, Martin V Hamann, Tobias Kern, Gesche K Gerresheim, Fabian Lindel, Erik Serrao, Paul Lesbats, Alan N Engelman, Peter Cherepanov, Dirk Lindemann
Publikováno v:
PLoS Pathogens, Vol 12, Iss 8, p e1005860 (2016)
Unlike for other retroviruses, only a few host cell factors that aid the replication of foamy viruses (FVs) via interaction with viral structural components are known. Using a yeast-two-hybrid (Y2H) screen with prototype FV (PFV) Gag protein as bait
Externí odkaz:
https://doaj.org/article/33ef903bedf34a2d909d5551b84b38cd
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137797 (2015)
Hepatoma-derived growth factor (HDGF) related protein 2 (HRP2) and lens epithelium-derived growth factor (LEDGF)/p75 are closely related members of the HRP2 protein family. LEDGF/p75 has been implicated in numerous human pathologies including cancer,
Externí odkaz:
https://doaj.org/article/0711bc4b6e1842b4bb05b59c66511675