Nasal immunization with H7 flagellin protects mice against hemolytic uremic syndrome secondary to Escherichia coli O157:H7 gastrointestinal infection

Autor: Alan Mauro Bernal, Fernando Nicolás Sosa, María Florencia Todero, Daniela Romina Montagna, Mónica Elba Vermeulen, Romina Jimena Fernández-Brando, María Victoria Ramos, Agustina Juliana Errea, Martin Rumbo, Marina Sandra Palermo

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)

IntroductionShiga-toxin (Stx) producing Escherichia coli (STEC) O157:H7 is the most frequent serotype associated with hemolytic uremic syndrome (HUS) after gastrointestinal infections. Protection against HUS secondary to STEC infections has been expe

Externí odkaz: https://doaj.org/article/ece0654e14f34e56adf05550680aea6b

Human Recombinant Fab Fragment Neutralizes Shiga Toxin Type 2 Cytotoxic Effects in vitro and in vivo

Autor: Daniela Luz, Maria Marta Amaral, Flavia Sacerdoti, Alan Mauro Bernal, Wagner Quintilio, Ana Maria Moro, Marina Sandra Palermo, Cristina Ibarra, Roxane Maria Fontes Piazza

Publikováno v: Toxins, Vol 10, Iss 12, p 508 (2018)

Shiga toxin (Stx) producing Escherichia coli (STEC) is responsible for causing hemolytic uremic syndrome (HUS), a life-threatening thrombotic microangiopathy characterized by thrombocytopenia, hemolytic anemia, and acute renal failure after bacterial

Externí odkaz: https://doaj.org/article/03ad8eb2008244f09f00787a80f5e0a6

Differential Outcome between BALB/c and C57BL/6 Mice after Escherichia coli O157:H7 Infection Is Associated with a Dissimilar Tolerance Mechanism

Autor: Marina S. Palermo, María Victoria Ramos, Mónica Vermeulen, Alan Mauro Bernal, Romina Jimena Fernandez-Brando, Andrea Cecilia Bruballa, Elsa Zotta, Gonzalo Ezequiel Pineda, Martín Rumbo, Gabriela A. Fiorentino

Publikováno v: SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
Infect Immun

Enterohemorrhagic Escherichia coli (EHEC) infections can result in a wide range of clinical presentations despite that EHEC strains belong to the O157:H7 serotype, one of the most pathogenic forms. Although pathogen virulence influences disease outco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcb993f4b32aa765b03828efedf34712
http://sedici.unlp.edu.ar/handle/10915/141078

Mechanisms involved in the adaptation of Escherichia coli O157:H7 to the host intestinal microenvironment

Autor: Stephen F. Fitzgerald, M Victoria Ramos, Romina Jimena Fernandez-Brando, Marina S. Palermo, David L. Gally, Jai J. Tree, Sean P. McAteer, Alan Mauro Bernal, Gonzalo Ezequiel Pineda, Johanna Montañez-Culma, Yennifer Cortes-Araya, Federico Fuentes

Publikováno v: Fernandez-Brando, R J, McAteer, S P, Montañez-Culma, J, Cortés-Araya, Y, Tree, J, Bernal, A, Fuentes, F, Fitzgerald, S, Pineda, G E, Ramos, M V, Gally, D L & Palermo, M S 2020, ' Mechanisms involved in the adaptation of Escherichia coli O157:H7 to the host intestinal microenvironment ', Clinical science, vol. 134, no. 24, pp. 3283-3301 . https://doi.org/10.1042/CS20200971

Host adaptation of pathogens may increase intra- and interspecies transmission. We showed previously that the passage of a clinically isolated enterohemorrhagic Escherichia coli (EHEC) O157 strain (125/99) through the gastrointestinal tract of mice i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff174500c9f25add904e5fca53c9a058
https://pubmed.ncbi.nlm.nih.gov/33346356

Role of Shiga Toxins in Cytotoxicity and Immunomodulatory Effects of Escherichia coli O157:H7 during Host-Bacterial Interactions in vitro

Autor: Romina Jimena Fernandez-Brando, Carolina Maiumi Shiromizu, Gonzalo Ezequiel Pineda, Analía Silvina Trevani, Marina S. Palermo, Andrea Cecilia Bruballa, Manuel J. Muñoz, Leticia V. Bentancor, Florencia Sabbione, María Victoria Ramos, Alan Mauro Bernal

Publikováno v: Toxins, Vol 12, Iss 1, p 48 (2020)
Toxins
Volume 12
Issue 1
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Enterohemorrhagic Escherichia coli (EHEC) strains are food-borne pathogens that can cause different clinical conditions. Shiga toxin 2a and/or 2c (Stx2)-producing E. coli O157:H7 is the serotype most frequently associated with severe human disease. I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9fdcff182f5930d8674854cd055a3e9
https://doi.org/10.3390/toxins12010048