Výsledky vyhledávání - "Alan Macwhannell"

Clinical management of gastrointestinal disturbances in patients with myelodysplastic syndromes receiving iron chelation treatment with deferasirox

Autor: Dominik Selleslag, Thamer Sliwa, Christiane Schumann, Antonio Almeida, Agnes Guerci-Bresler, Alan MacWhannell, Wolf-K. Hofmann, Emanuele Angelucci, John B. Porter, Florian Nolte, Petra Muus, Blanca Xicoy, Photis Beris

Publikováno v: Leukemia Research, 35, 1131-5
Leukemia Research, 35, 9, pp. 1131-5

Item does not contain fulltext Myelodysplastic syndromes are characterized by ineffective hematopoiesis resulting in peripheral cytopenias. The majority of patients is dependent on regular transfusions of packed red blood cells leading to a secondary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a20272c5a4a6ec844d02042dbab3029
https://hdl.handle.net/2066/96734

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Elevated, combined serum free light chain levels and increased mortality: a 5-year follow-up, UK study

Autor: Joanne Taylor, Jayne Parkes, Tracy Lovatt, Stephen Harding, Lakhvir K. Assi, Sunil Handa, Abraham Jacob, Supratik Basu, Alan Macwhannell, Seetharam Anandram

Publikováno v: Journal of clinical pathology. 65(11)

AimsAbnormal serum free light chain (FLC) ratios are diagnostically important in almost all plasma cell disorders. However, absolute increases in polyclonal FLC levels are often discarded as inconsequential. Here we report an association between incr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d47e09783fab7106f819e5e9faf08110
https://pubmed.ncbi.nlm.nih.gov/22923765

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Elevated FOSB-expression; a potential marker of valproate sensitivity in AML

Autor: Farhat L. Khanim, David Grimwade, Julie Arrazi, Alistair Sawers, Mark Cook, Christopher M. Bunce, Rachel E. Hayden, Supratik Basu, Francesco Falciani, Karl P. Nightingale, Sylvie D. Freeman, Michael J. Griffiths, Charles Craddock, Bryan M. Turner, Charlotte Bradbury, Alan MacWhannell, Adam Rye

Publikováno v: British journal of haematology. 144(3)

Summary Histone deacetylase inhibitors (HDIs) are emerging as valuable new agents in the treatment of acute myeloid leukaemia (AML). However, since response rates to these agents alone are low, we sought to identify markers associated with responsive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56d88c98f81be95a6e3e0284fc5e2ee3
https://pubmed.ncbi.nlm.nih.gov/19036090

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Antibody-mediated pure red cell aplasia in a dialysis patient receiving darbepoetin alfa as the sole erythropoietic agent

Autor: Helen E. Jones, Paul Carmichael, Sunil Handa, Kanwaljit Sandhu, Johann Nicholas, Maurice A. Jackson, Jonathan Odum, Ghulam J. Mufti, Nicole Casadevall, Iain C. Macdougall, Abraham Jacob, Paul Rylance, Alan MacWhannell, Supratik Basu, Faisal Wahid

Publikováno v: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 21(10)

The introduction of recombinant human erythro-poietin (epoetin) transformed the management ofanaemia for the vast majority of dialysis patients.The immediate benefit of transfusion-independencewas a lower risk of contracting blood-borne infectionsand

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::303961bb30701622dc26f35b26676411
https://pubmed.ncbi.nlm.nih.gov/17220167

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Computational Algorithm Based On Serum Immunoassays for the Identification of Haematological Disease May Identify Patients with Other Acute Disorders

Autor: Stephen Harding, Supratik Basu, Sunil Honda, David Sutton, Jeffrey Faint, Ladan Mirbahai, Abe Jacob, Alan Macwhannell, Anandram Seetharam

Publikováno v: Blood. 120:4001-4001

Abstract 4001 Introduction Serum free light chain (FLC) measurements are used routinely to identify monoclonal immunoglobulin (M-Ig) production in patients. In addition, summated kappa + lambda concentrations have recently been shown to have prognost

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b9f484da66f70e5a4de5c082a8b4625
https://doi.org/10.1182/blood.v120.21.4001.4001

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Immunoglobulin Heavy/Light Chain Ratios as An Alternative to Immunofixation In the Identification of Monoclonal Gammopathies

Autor: Anandram Seetharam, Tracy Lovatt, Supratik Basu, Alan Macwhannell, Sunil Honda, Stephen Harding, Abe Jacob

Publikováno v: Blood. 116:5018-5018

Abstract 5018 Introduction Historically, serum protein electrophoresis (SPE), urine protein electrophoresis (UPE) and immunofixation (IFE) have been used to identify and quantify monoclonal proteins (M-proteins). Whilst this approach is adequate for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5017e8998f9a9f97e16abcc97da86723
https://doi.org/10.1182/blood.v116.21.5018.5018

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Standard Dose Chemotherapy 3+7 Induces Complete Remission in Patients Over 80 Years Old with Single-Lineage Acute Myeloid Leukemias and Normal Karyotype

Autor: Jirina Galikova, Zuzana Zemanova, Kyra Michalova, Petr Lemez, Jan Stejskal, Alan MacWhannell

Publikováno v: Blood. 112:4006-4006

Survival of elderly patients with de novo acute myeloid leukemia (AML) is poor. A single published study on patients with AML aged 80 years and above (DeLima et al., Br. J. Haematol.1996; 93: 89) concluded that chemotherapy was not indicated since me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e75a2831eea9f022e37fcdaf9910ea16
https://doi.org/10.1182/blood.v112.11.4006.4006

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