Zobrazeno 1 - 10
of 585
pro vyhledávání: '"Alan Mackay"'
Autor:
Arnault Tauziède-Espariat, Lea L. Friker, Gunther Nussbaumer, Brigitte Bison, Volodia Dangouloff-Ros, Alice Métais, David Sumerauer, Josef Zamecnik, Martin Benesch, Thomas Perwein, Dannis van Vuurden, Pieter Wesseling, Andrés Morales La Madrid, Maria Luisa Garrè, Manila Antonelli, Felice Giangaspero, Torsten Pietsch, Dominik Sturm, David T. W. Jones, Stefan M. Pfister, Yura Grabovska, Alan Mackay, Chris Jones, Jacques Grill, Yassine Ajlil, André O. von Bueren, Michael Karremann, Marion Hoffmann, Christof M. Kramm, Robert Kwiecien, David Castel, Gerrit H. Gielen, Pascale Varlet
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-11 (2024)
Abstract Diffuse pediatric-type high-grade gliomas (pedHGG), H3- and IDH-wildtype, encompass three main DNA-methylation-based subtypes: pedHGG-MYCN, pedHGG-RTK1A/B/C, and pedHGG-RTK2A/B. Since their first description in 2017 tumors of pedHGG-RTK2A/B
Externí odkaz:
https://doaj.org/article/a314c4fae9f64dd98df77f621bcc505c
Autor:
Hannah C. Leeson, Julio Aguado, Cecilia Gómez-Inclán, Harman Kaur Chaggar, Atefah Taherian Fard, Zoe Hunter, Martin F. Lavin, Alan Mackay-Sim, Ernst J. Wolvetang
Publikováno v:
Neurobiology of Disease, Vol 199, Iss , Pp 106562- (2024)
Ataxia Telangiectasia (AT) is a rare disorder caused by mutations in the ATM gene and results in progressive neurodegeneration for reasons that remain poorly understood. In addition to its central role in nuclear DNA repair, ATM operates outside the
Externí odkaz:
https://doaj.org/article/b826d148b82f43529a6250e191ea9f40
Autor:
Giulia Pericoli, Angela Galardi, Alessandro Paolini, Lucia Lisa Petrilli, Gerardo Pepe, Alessandro Palma, Marta Colletti, Roberta Ferretti, Ezio Giorda, Stefano Levi Mortera, Anna Burford, Andrea Carai, Angela Mastronuzzi, Alan Mackay, Lorenza Putignani, Chris Jones, Luisa Pascucci, Hector Peinado, Manuela Helmer-Citterich, Emmanuel de Billy, Andrea Masotti, Franco Locatelli, Angela Di Giannatale, Maria Vinci
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-24 (2023)
Abstract Background Paediatric-type diffuse High-Grade Gliomas (PDHGG) are highly heterogeneous tumours which include distinct cell sub-populations co-existing within the same tumour mass. We have previously shown that primary patient-derived and opt
Externí odkaz:
https://doaj.org/article/d7785bfb848a4134a77dbd73c0fde68b
Autor:
Gautam Wali, Sue-Faye Siow, Erandhi Liyanage, Kishore R. Kumar, Alan Mackay-Sim, Carolyn M. Sue
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
HSP-SPAST is the most common form of hereditary spastic paraplegia (HSP), a neurodegenerative disease causing lower limb spasticity. Previous studies using HSP-SPAST patient-derived induced pluripotent stem cell cortical neurons have shown that patie
Externí odkaz:
https://doaj.org/article/3201b17da6cb45dfba36c4145e81a41f
Autor:
Lucia Lisa Petrilli, Claudia Fuoco, Alessandro Palma, Luca Pasquini, Giulia Pericoli, Yura Grabovska, Alan Mackay, Sabrina Rossi, Angel M. Carcaboso, Andrea Carai, Angela Mastronuzzi, Chris Jones, Gianni Cesareni, Franco Locatelli, Maria Vinci
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Paediatric-type diffuse high-grade gliomas (PDHGG) are aggressive tumors affecting children and young adults, with no effective treatment. These highly heterogeneous malignancies arise in different sites of the Central Nervous System (CNS), carrying
Externí odkaz:
https://doaj.org/article/94b54df944b44522a711132ecb3fea4b
Autor:
Giada Del Baldo, Andrea Carai, Rachid Abbas, Antonella Cacchione, Mara Vinci, Valentina Di Ruscio, Giovanna Stefania Colafati, Sabrina Rossi, Francesca Diomedi Camassei, Nicola Maestro, Sara Temelso, Giulia Pericoli, Emmanuel De Billy, Isabella Giovannoni, Alessia Carboni, Martina Rinelli, Emanuele Agolini, Alan Mackay, Chris Jones, Silvia Chiesa, Mario Balducci, Franco Locatelli, Angela Mastronuzzi
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 14 (2022)
Background: Diffuse intrinsic pontine glioma (DIPG) is a fatal disease with a median overall survival (OS) of less than 12 months after diagnosis. Radiotherapy (RT) still remains the mainstay treatment. Several other therapeutic strategies have been
Externí odkaz:
https://doaj.org/article/6424a769c3b241c4b0d3dc614eda6a04
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract A central need for neurodegenerative diseases is to find curative drugs for the many clinical subtypes, the causative gene for most cases being unknown. This requires the classification of disease cases at the genetic and cellular level, an
Externí odkaz:
https://doaj.org/article/8ca07526bb474194b884a6feb2839f05
Autor:
Yura Grabovska, Alan Mackay, Patricia O’Hare, Stephen Crosier, Martina Finetti, Edward C. Schwalbe, Jessica C. Pickles, Amy R. Fairchild, Aimee Avery, Julia Cockle, Rebecca Hill, Janet Lindsey, Debbie Hicks, Mark Kristiansen, Jane Chalker, John Anderson, Darren Hargrave, Thomas S. Jacques, Karin Straathof, Simon Bailey, Chris Jones, Steven C. Clifford, Daniel Williamson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Here, using methylCIBERSORT, the authors characterize the tumour-immune microenvironment of paediatric central nervous system (CNS) tumours and its association with tumour type and prognosis. These findings suggest that immuno-methylomic profiling ma
Externí odkaz:
https://doaj.org/article/ec15b2c4e08f447294d1c85b886169aa
Autor:
Sweelin Chew, Riikka Lampinen, Liudmila Saveleva, Paula Korhonen, Nikita Mikhailov, Alexandra Grubman, Jose M. Polo, Trevor Wilson, Mika Komppula, Teemu Rönkkö, Cheng Gu, Alan Mackay-Sim, Tarja Malm, Anthony R. White, Pasi Jalava, Katja M. Kanninen
Publikováno v:
Particle and Fibre Toxicology, Vol 17, Iss 1, Pp 1-15 (2020)
Abstract Background The adverse effects of air pollutants including particulate matter (PM) on the central nervous system is increasingly reported by epidemiological, animal and post-mortem studies in the last decade. Oxidative stress and inflammatio
Externí odkaz:
https://doaj.org/article/1c2a6611524442c9936f8b5edcd03f3f
Autor:
Hannah C. Leeson, Zoe Hunter, Harman Kaur Chaggar, Martin F. Lavin, Alan Mackay-Sim, Ernst J. Wolvetang
Publikováno v:
Stem Cell Research, Vol 56, Iss , Pp 102528- (2021)
Ataxia Telangiectasia is a rare autosomal recessive disorder caused by a mutated ATM gene. The most debilitating symptom of Ataxia Telangiectasia is the progressive neurodegeneration of the cerebellum, though the molecular mechanisms driving this deg
Externí odkaz:
https://doaj.org/article/6699cf1e6cf540f2a7dc0930af1fb9f5