Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Alan M. Zahler"'
Autor:
Jessie M N G L Suzuki, Kenneth Osterhoudt, Catiana H Cartwright-Acar, Destiny R Gomez, Sol Katzman, Alan M Zahler
Publikováno v:
PLoS Genetics, Vol 18, Iss 2, p e1010028 (2022)
Pre-mRNA splicing is an essential step of eukaryotic gene expression carried out by a series of dynamic macromolecular protein/RNA complexes, known collectively and individually as the spliceosome. This series of spliceosomal complexes define, assemb
Externí odkaz:
https://doaj.org/article/cdcfaf0bec86410ba01793f3b79cae02
Autor:
Catiana H Cartwright-Acar, Kenneth Osterhoudt, Jessie M N G L Suzuki, Destiny R Gomez, Sol Katzman, Alan M Zahler
Publikováno v:
Nucleic acids research. 50(20)
The spliceosome undergoes extensive rearrangements as it assembles onto precursor messenger RNAs. In the earliest assembly step, U1snRNA identifies the 5′ splice site. However, U1snRNA leaves the spliceosome relatively early in assembly, and 5′ s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1460e473cee4dd5ad1e9e33b780f87b0
https://pubmed.ncbi.nlm.nih.gov/36321655
https://pubmed.ncbi.nlm.nih.gov/36321655
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0170870 (2017)
During its sexual reproduction, the stichotrichous ciliate Oxytricha trifallax orchestrates a remarkable transformation of one of the newly formed germline micronuclear genomes. Hundreds of thousands of gene pieces are stitched together, excised from
Externí odkaz:
https://doaj.org/article/8aa70b65858843faa0176a516895eac1
Pre-mRNA splicing is an essential step of eukaryotic gene expression carried out by a series of dynamic macromolecular protein/RNA complexes, known collectively and individually as the spliceosome. This series of spliceosomal complexes define, assemb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d78799fbde78aaec69ffc67b8e116c06
https://doi.org/10.1101/2021.06.30.450627
https://doi.org/10.1101/2021.06.30.450627
Autor:
J. Matthew Ragle, Christine Guthrie, Megan Mayerle, Sol Katzman, Samira Yitiz, Lucero E Rogel, Alan M. Zahler, Cameron M. Soulette, Andrea Ramirez
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 6
Pre-mRNA splicing must occur with extremely high fidelity. Spliceosomes assemble onto pre-mRNA guided by specific sequences (5′ splice site, 3′ splice site, and branchpoint). When splice sites are mutated, as in many hereditary diseases, the spli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2cc6d448e5a659eab1812458c5b3c60
https://doi.org/10.1073/pnas.1819020116
https://doi.org/10.1073/pnas.1819020116
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42371 (2012)
Ciliated protozoans possess two types of nuclei; a transcriptionally silent micronucleus, which serves as the germ line nucleus, and a transcriptionally active macronucleus, which serves as the somatic nucleus. The macronucleus is derived from a new
Externí odkaz:
https://doaj.org/article/12d1d4eb792c4664a6cd831d7a669c6b
Autor:
Marissa L Glover, Sol Katzman, James Matthew Ragle, Samira Yitiz, Lucero E Rogel, Alan M. Zahler
Publikováno v:
RNA. 24:1314-1325
The tri-snRNP 27K protein is a component of the human U4/U6-U5 tri-snRNP and contains an N-terminal phosphorylated RS domain. In a forward genetic screen in C. elegans, we previously identified a dominant mutation, M141T, in the highly-conserved C-te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::318a8866f42369e725e4c9da752db7ce
https://doi.org/10.1261/rna.066878.118
https://doi.org/10.1261/rna.066878.118
Autor:
Sergio Barberan-Soler, Alan M Zahler
Publikováno v:
PLoS Genetics, Vol 4, Iss 2, p e1000001 (2008)
Alternative splicing generates protein diversity and allows for post-transcriptional gene regulation. Estimates suggest that 10% of the genes in Caenorhabditis elegans undergo alternative splicing. We constructed a splicing-sensitive microarray to de
Externí odkaz:
https://doaj.org/article/c38489f533324027aef68c0d694df45f
Autor:
Jennifer L Kabat, Sergio Barberan-Soler, Paul McKenna, Hiram Clawson, Tracy Farrer, Alan M Zahler
Publikováno v:
PLoS Computational Biology, Vol 2, Iss 7, p e86 (2006)
Many alternative splicing events are regulated by pentameric and hexameric intronic sequences that serve as binding sites for splicing regulatory factors. We hypothesized that intronic elements that regulate alternative splicing are under selective p
Externí odkaz:
https://doaj.org/article/9d0dd288e00e496e9be1f86ad694c491
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 2, p e0170870 (2017)
PLoS ONE, Vol 12, Iss 2, p e0170870 (2017)
During its sexual reproduction, the stichotrichous ciliate Oxytricha trifallax orchestrates a remarkable transformation of one of the newly formed germline micronuclear genomes. Hundreds of thousands of gene pieces are stitched together, excised from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d101a0efc28985decde720ae85827f5
http://europepmc.org/articles/PMC5312943
http://europepmc.org/articles/PMC5312943