Výsledky vyhledávání - "Alan M. Solinger"

Risankizumab, an IL-23 inhibitor, for ankylosing spondylitis: results of a randomised, double-blind, placebo-controlled, proof-of-concept, dose-finding phase 2 study

Autor: Carlo Salvarani, Dominique Baeten, Lai-Shan Tam, David B. Hall, Alan M. Solinger, Steven J. Padula, Tae-Hwan Kim, Chandrasena Pamulapati, Paul Scholl, James Cheng-Chung Wei, Mikkel Østergaard, Joachim Sieper, Pentti Järvinen, Stella Aslanyan, Sudha Visvanathan, Yakov Datsenko

Publikováno v: Annals of the Rheumatic Diseases
Baeten, D, Østergaard, M, Wei, J C-C, Sieper, J, Järvinen, P, Tam, L-S, Salvarani, C, Kim, T-H, Solinger, A, Datsenko, Y, Pamulapati, C, Visvanathan, S, Hall, D B, Aslanyan, S, Scholl, P & Padula, S J 2018, ' Risankizumab, an IL-23 inhibitor, for ankylosing spondylitis : results of a randomised, double-blind, placebo-controlled, proof-of-concept, dose-finding phase 2 study ', Annals of the Rheumatic Diseases, vol. 77, no. 9, pp. 1295-1302 . https://doi.org/10.1136/annrheumdis-2018-213328
Annals of the rheumatic diseases, 77(9), 1295-1302. BMJ Publishing Group

ObjectivesTo evaluate the efficacy and safety of risankizumab, a humanised monoclonal antibody targeting the p19 subunit of interleukin-23 (IL-23), in patients with active ankylosing spondylitis (AS).MethodsA total of 159 patients with biological-na�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff74393412a5f8c7bb73f2246c6abbaa
https://hdl.handle.net/11380/1167263

Zobrazit plný text záznamu

Effects of gevokizumab on glycemia and inflammatory markers in type 2 diabetes

Autor: Charles A. Dinarello, Claudia Cavelti-Weder, Malaika Kurz-Levin, Marc A. Stahel, Andrea Babians-Brunner, Marc Y. Donath, Alan M. Solinger, Cornelia Keller, Thomas Mandrup-Poulsen, Hany Zayed

Publikováno v: Diabetes care
Diabetes Care, 35, 8, pp. 1654-62
Diabetes Care
Diabetes Care, 35, 1654-62

OBJECTIVE Metabolic activation of the innate immune system governed by interleukin (IL)-1β contributes to β-cell failure in type 2 diabetes. Gevokizumab is a novel, human-engineered monoclonal anti–IL-1β antibody. We evaluated the safety and bio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d887ea542a1af368905d5096883d9c6c

Zobrazit plný text záznamu

Interleukin-1β-regulating antibody XOMA 052 (gevokizumab) in the treatment of acute exacerbations of resistant uveitis of Behçet's disease: an open-label pilot study

Autor: Ahmet Gül, Bahar Artım Esen, Charles A. Dinarello, Alan M. Solinger, Leonid L. Reznikov, A. M. Mirza, Patrick J. Scannon, Ilknur Tugal-Tutkun

Publikováno v: Annals of the Rheumatic Diseases. 71:563-566

Objective Uveitis and retinal vasculitis are sight-threatening manifestations of Behcet9s disease with limited treatment options. This pilot study aimed to evaluate the safety, pharmacokinetics and clinical activity of XOMA 052 (gevokizumab), a recom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8aa9a4f962a3ad8ecd2098a8b1376f5
https://doi.org/10.1136/annrheumdis-2011-155143

Zobrazit plný text záznamu

The safety of anakinra in high-risk patients with active rheumatoid arthritis: Six-month observations of patients with comorbid conditions

Autor: Roy Fleischmann, Gino DiVittorio, Joy Schechtman, Thomas Liu, Alan M. Solinger, John Tesser, Sanford Hartman, Michael Schiff

Publikováno v: Arthritis & Rheumatism. 50:1752-1760

Objective To determine in a placebo-controlled, double-blind trial the safety profile of daily anakinra (Kineret) use in patients with active rheumatoid arthritis (RA) and concurrent comorbid conditions. Methods In 169 centers in 9 countries, 1,414 p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c43da30f151a15282a39bca8fd735a2
https://doi.org/10.1002/art.20277

Zobrazit plný text záznamu

Rheumatic manifestations of human immunodeficiency virus

Autor: Alan M. Solinger

Publikováno v: Current Rheumatology Reports. 5:205-209

Since July 1983, various rheumatic, musculoskeletal, or other immune disorders characterized by dysregulation have been associated with HIV and AIDS. Infections occur, but with a lower frequency than expected in a patient population with a disorder p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b312859dcb4c5b2f39011a435b72867e
https://doi.org/10.1007/s11926-003-0068-7

Zobrazit plný text záznamu

Anti-IL-23A mAb BI 655066 for treatment of moderate-to-severe psoriasis: Safety, efficacy, pharmacokinetics, and biomarker results of a single-rising-dose, randomized, double-blind, placebo-controlled trial

Autor: Alexander White, Elaine E.L. Wang, Laura K. Ferris, Bojan Lalovic, Frank Wagner, Steven J. Padula, James G. Krueger, Sudha Visvanathan, Alan M. Solinger, Alan Menter, Paul Scholl, Stella Aslanyan, David B. Hall

Publikováno v: The Journal of allergy and clinical immunology. 136(1)

Background IL-23 is associated with plaque psoriasis susceptibility and pathogenesis. BI 655066 is a fully human IgG 1 mAb specific for the IL-23 p19 subunit. Objective This first-in-human proof-of-concept study evaluated the clinical and biological

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5046da1c682d039c2e73b12ef9d62319
https://pubmed.ncbi.nlm.nih.gov/25769911

Zobrazit plný text záznamu

HUMAN IMMUNODEFICIENCY VIRUS INFECTION IS NOT ASSOCIATED WITH REITER’S SYNDROME

Autor: Alan M. Solinger, Marcus R. Clark, Marc C. Hochberg

Publikováno v: Rheumatic Disease Clinics of North America. 18:267-276

The cohorts presented are the largest available and the only ones for which suitable controls exist. They suggest that RS occurs in less than 1% of individuals infected with HIV. Additionally, infection with HIV is no independently associated with RS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f0f1b2c811d00d92f401bbb9fefa8bb9
https://doi.org/10.1016/s0889-857x(21)00723-7

Zobrazit plný text záznamu

Induction of Autoantibodies by Human Immunodeficiency Virus Infection and Their Significance

Autor: Evelyn V. Hess, Alan M. Solinger

Publikováno v: Rheumatic Disease Clinics of North America. 17:157-176

SUMMARY Although many of the changes in HIV and AIDS appear to be global, on closer investigation the defects are specific and can be explained by recognized mechanisms. Despite a demonstrated concurrent polyclonal B-cell activation, studies fail to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::638612e30094ef187c1eb24c289d773a
https://doi.org/10.1016/s0889-857x(21)00095-8

Zobrazit plný text záznamu

Emergence of acyclovir-resistant varicella zoster virus in an AIDS patient on prolonged acyclovir therapy

Autor: Alan M. Solinger, William G. Hoppenjans, Karen K. Biron, Calvin C. Linnemann

Publikováno v: AIDS. 4:577-580

We demonstrate for the first time the appearance of acyclovir resistance in serial varicella zoster isolates from a patient treated with acyclovir. We recovered varicella zoster virus three times over a period of 5 months from the skin lesions of thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db94a28b8f5b663d38f78a09411a0ccd
https://doi.org/10.1097/00002030-199006000-00014

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání