Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Alan M. Simm"'
Publikováno v:
Journal of Antimicrobial Chemotherapy. 51:523-530
The penicillin binding protein (PBP) genes dacA, dacB and ftsI from 14 cefuroxime-resistant (CXM(R)) isolates and three clinical isolates with low CXM MIC for non-beta-lactamase-producing Haemophilus influenzae type b were molecularly characterized.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1baf6875ed9d2381b648cef8ebcc888
https://doi.org/10.1093/jac/dkg107
https://doi.org/10.1093/jac/dkg107
Autor:
Mark Toleman, Tanya A. Murphy, Timothy R. Walsh, Doug Biedenbach, Ana Cristina Gales, Alan M. Simm, Ronald N. Jones
Publikováno v:
Journal of Antimicrobial Chemotherapy. 50:673-679
The gene encoding the metallo-beta-lactamase SPM-1 was cloned from a genomic library of Pseudomonas aeruginosa strain 48-1997 A. The insert carrying spm-1 possessed a GC content of 47%, indicating that it is of non-Pseudomonas origin. Upstream of spm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6845662a059cc7c91999225363057802
https://doi.org/10.1093/jac/dkf210
https://doi.org/10.1093/jac/dkf210
Autor:
Alan M. Simm, Matthew B. Avison
Publikováno v:
Journal of Antimicrobial Chemotherapy. 50:331-338
Legionella pneumophila Philadelphia-1 (ATCC 33152) produces a serine active site beta-lactamase. The chromosomal gene that encodes this enzyme, loxA, has been cloned by PCR using information from the L. pneumophila Philadelphia-1 genome sequencing pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f62850a32fe7eef609718e2cf2f90cb0
https://doi.org/10.1093/jac/dkf135
https://doi.org/10.1093/jac/dkf135
Autor:
Michael W. Crowder, Anne L. Carenbauer, Stephen E. Halford, Timothy R. Walsh, Anthony R. Clarke, Peter M. Bennett, John H. Bateson, Catherine S. Higgins, Alan M. Simm
Publikováno v:
Journal of Biological Chemistry. 277:24744-24752
The L1 metallo-beta-lactamase from Stenotrophomonas maltophilia is unique among this class of enzymes because it is tetrameric. Previous work predicted that the two regions of important intersubunit interaction were the residue Met-140 and the N-term
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8fb80158a92d293f039d8503e175eca
https://doi.org/10.1074/jbc.m201524200
https://doi.org/10.1074/jbc.m201524200
Autor:
Olivia Erdozain, Matthew B. Avison, Peter M. Bennett, Alan M. Simm, Pannika R. Niumsup, Steven T. Pullan, Timothy R. Walsh, Catherine S. Higgins
Publikováno v:
FEBS Letters. 509:350-354
Caulobacter crescentus 101123 possesses a gene (Mbl1b) encoding a metallo-β-lactamase with 32% amino acid identity to the L1 metallo-β-lactamase from Stenotrophomonas maltophilia. The gene was cloned into an expression vector and the enzyme, Mbl1b,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3711f85b3f6aaaf5323d476e61c48a04
https://doi.org/10.1016/s0014-5793(01)03152-0
https://doi.org/10.1016/s0014-5793(01)03152-0
Autor:
Peter M. Bennett, Matthew B. Avison, Catherine S. Higgins, Lee Jamieson, Alan M. Simm, Timothy R. Walsh
Publikováno v:
Journal of Antimicrobial Chemotherapy. 47:745-754
Ochrobactrum anthropi is resistant to most cephalosporins and penicillins due, at least in part, to the inducible expression of a single beta-lactamase. The beta-lactamase gene has been cloned and sequenced. It encodes an AmpC-type class 1 serine act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af5dadc07a23737fd1306d9cfae915f3
https://doi.org/10.1093/jac/47.6.745
https://doi.org/10.1093/jac/47.6.745
Expanded molecular diversity generation during directed evolution by trinucleotide exchange (TriNEx)
Publikováno v:
Nucleic Acids Research
Trinucleotide exchange (TriNEx) is a method for generating novel molecular diversity during directed evolution by random substitution of one contiguous trinucleotide sequence for another. Single trinucleotide sequences were deleted at random position
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b2c085c23ed4f6ded834363611b5fd0
https://orca.cardiff.ac.uk/id/eprint/8800/1/Nucl._Acids_Res.-2008-Baldwin-e77.pdf
https://orca.cardiff.ac.uk/id/eprint/8800/1/Nucl._Acids_Res.-2008-Baldwin-e77.pdf
Autor:
John Crosby, E. Joel Loveridge, Peter M. Bennett, Matthew B. Avison, Timothy R. Walsh, Alan M. Simm
Bulgecin A, a sulphonated N-acetyl-D-glucosamine unit linked to a 4-hydroxy-5-hydroxymethylproline ring by a beta-glycosidic linkage, is a novel type of inhibitor for binuclear metallo-beta-lactamases. Using steady-state kinetic analysis with nitroce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e738b57b0877be7643b69caaf98b1c1
https://cronfa.swan.ac.uk/Record/cronfa29994
https://cronfa.swan.ac.uk/Record/cronfa29994
Autor:
Matthew B. Avison, Alan M. Simm, Timothy R. Walsh, Kurshid Nurmahomed, Pannika Niumsup, Peter M. Bennett
Publikováno v:
The Journal of antimicrobial chemotherapy. 51(6)
Aeromonas hydrophila T429125, a human clinical isolate, possesses three coordinately inducible beta-lactamases encoded by ampH (class D beta-lactamase), cepH (class C beta-lactamase) and imiH (class B beta-lactamase). We report that upstream of ampH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::667d006876d6064d7405026dc4c22785
https://pubmed.ncbi.nlm.nih.gov/12746371
https://pubmed.ncbi.nlm.nih.gov/12746371
Publikováno v:
Antimicrobial agents and chemotherapy. 47(2)
SPM-1 is a new metallo-β-lactamase recently identified in Pseudomonas aeruginosa strain 48-1997A, isolated in Sao Paulo, Brazil. Kinetic analysis demonstrated that SPM-1 has a broad hydrolytic profile across a wide range of β-lactam antibiotics. Co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c6ecb7c9916e52a1f47cadbc2cfe5c6
https://pubmed.ncbi.nlm.nih.gov/12543663
https://pubmed.ncbi.nlm.nih.gov/12543663