Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Alan M. Roseman"'
Autor:
Robert E. Turnbull, Louise Fairall, Almutasem Saleh, Emma Kelsall, Kyle L. Morris, T. J. Ragan, Christos G. Savva, Aditya Chandru, Christopher J. Millard, Olga V. Makarova, Corinne J. Smith, Alan M. Roseman, Andrew M. Fry, Shaun M. Cowley, John W. R. Schwabe
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The MiDAC complex recruits class I histone deacetylases to chromatin but little is known about its precise structure and function. Here, the authors explore the role of MiDAC in the cell cycle and during mouse embryogenesis, and present cryoEM struct
Externí odkaz:
https://doaj.org/article/6a71d260306a424c936ce21edc133482
Autor:
Tomas Adomavicius, Margherita Guaita, Yu Zhou, Martin D. Jennings, Zakia Latif, Alan M. Roseman, Graham D. Pavitt
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
During the integrated stress response, translation is modulated through the phosphorylation of translation initiation factor eIF2 and the formation of a complex with eIF2B. Here the authors present structures of the eIF2:eIF2B complex with and withou
Externí odkaz:
https://doaj.org/article/b178b1da56a2498cb1e4d2d9ec16bc26
Autor:
Luigi De Colibus, Elina Roine, Thomas S. Walter, Serban L. Ilca, Xiangxi Wang, Nan Wang, Alan M. Roseman, Dennis Bamford, Juha T. Huiskonen, David I. Stuart
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Here, the authors present the cryo-EM structure of the archaeal virus SH1 at 3.8 Å resolution and show how the major capsid proteins assemble into hetero-hexamers, providing insights into the assembly process of this and related PRD1-adeno lineage v
Externí odkaz:
https://doaj.org/article/c49688e838814e378948c888e788bdd5
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 8, p 4087 (2022)
As essential components of our connective tissues, elastic fibres give tissues such as major blood vessels, skin and the lungs their elasticity. Their formation is complex and co-ordinately regulated by multiple factors. In this review, we describe k
Externí odkaz:
https://doaj.org/article/1d602c0135d3486f80508231dfa6b6d0
Autor:
Alan R. F. Godwin, Rana Dajani, Xinyang Zhang, Jennifer Thomson, David F. Holmes, Christin S. Adamo, Gerhard Sengle, Michael J. Sherratt, Alan M. Roseman, Clair Baldock
Publikováno v:
Nature Structural & Molecular Biology. 30:608-618
Genetic mutations in fibrillin microfibrils cause serious inherited diseases, such as Marfan syndrome and Weill–Marchesani syndrome (WMS). These diseases typically show major dysregulation of tissue development and growth, particularly in skeletal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::400c67b7f71f6588859742122393a277
https://doi.org/10.1038/s41594-023-00950-8
https://doi.org/10.1038/s41594-023-00950-8
Autor:
Alan RF Godwin, Jennifer Thomson, David F Holmes, Christin S Adamo, Gerhard Sengle, Michael J Sherratt, Alan M Roseman, Clair Baldock
Genetic mutations in fibrillin microfibrils cause a range of serious inherited diseases such as Marfan syndrome (MFS) and Weill-Marchesani syndrome (WMS). These diseases typically show major dysregulation of tissue development and growth, particularl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b872a4f3960a89eb50d64c9385e52f4a
https://doi.org/10.1101/2022.08.26.505362
https://doi.org/10.1101/2022.08.26.505362
Autor:
Valeriy Titarenko, Alan M. Roseman
Publikováno v:
Acta Crystallographica. Section D, Structural Biology
Titarenko, V & Roseman, A 2021, ' Theoretical and practical approaches to improve the performance of local correlation algorithms for volume data analysis and shape recognition ', Acta Crystallographica Section D: Structural Biology, vol. 77, no. 4, 4, pp. 447-456 . https://doi.org/10.1107/S2059798321001212
Titarenko, V & Roseman, A 2021, ' Theoretical and practical approaches to improve the performance of local correlation algorithms for volume data analysis and shape recognition ', Acta Crystallographica Section D: Structural Biology, vol. 77, no. 4, 4, pp. 447-456 . https://doi.org/10.1107/S2059798321001212
Several approaches are presented to improve the performance of local correlation algorithms based on prior information about 3D search and target maps.
In this paper, several approaches to be used to accelerate algorithms for fitting an atomic s
In this paper, several approaches to be used to accelerate algorithms for fitting an atomic s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bb17616f0c0b40f7f72bad7bf7e62d3
http://europepmc.org/articles/PMC8025886
http://europepmc.org/articles/PMC8025886
Autor:
Muhammad Saleem, C. Alistair Siebert, Alan M. Roseman, Hannah Chan, Sebastian Aston-Deaville, Alessandra Facchetti, Ian M. Feavers, Richard F. Collins, Sunil Maharjan, Emil Carlsson, Angela Thistlethwaite, Jeremy P. Derrick
Publikováno v:
Aston-Deaville, S, Carlsson, E, Saleem, M, Thistlethwaite, A, Chan, H, Maharjan, S, Facchetti, A, Feavers, I M, Siebert, C A, Collins, R, Roseman, A & Derrick, J 2020, ' An assessment of the use of Hepatitis B Virus core protein virus-like particles to display heterologous antigens from Neisseria meningitidis ', Vaccine, vol. 38, no. 16, pp. 3201-3209 . https://doi.org/10.1016/j.vaccine.2020.03.001
Vaccine
Vaccine
Neisseria meningitidis is the causative agent of meningococcal meningitis and sepsis and remains a significant public health problem in many countries. Efforts to develop a comprehensive vaccine against serogroup B meningococci have focused on the us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f059b429288d71278721dc7b8e8aa82
https://doi.org/10.1016/j.vaccine.2020.03.001
https://doi.org/10.1016/j.vaccine.2020.03.001
Autor:
Sarah M. Smith, Gabrielle Laroque, Katherine M. Wood, Kyle L. Morris, Alan M. Roseman, Richard B. Sessions, Stephen J. Royle, Corinne J. Smith, Frances M. Brodsky
Publikováno v:
Biophysical Journal. 122:514a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::422aa4a849de3499244d3daea522d7ac
https://doi.org/10.1016/j.bpj.2022.11.2736
https://doi.org/10.1016/j.bpj.2022.11.2736
Autor:
Katherine M. Wood, Alan M. Roseman, Richard B. Sessions, Gabrielle Larocque, Kyle L. Morris, Sarah Marie Smith, Stephen J. Royle, Corinne J. Smith
Publikováno v:
Sarah, S, Roseman, A & Smith, C J 2021, ' Multi-modal adaptor-clathrin contacts drive coated vesicle assembly ', EMBO Journal, vol. 40, no. 19, e108795 . https://doi.org/10.15252/embj.2021108795
The EMBO Journal
Smith, S M, Larocque, G, Wood, K M, Morris, K L, Roseman, A M, Sessions, R B, Royle, S J & Smith, C J 2021, ' Multi-modal adaptor-clathrin contacts drive coated vesicle assembly ', EMBO Journal, vol. 40, no. 19, e108795, pp. 1-16 . https://doi.org/10.15252/embj.2021108795
The EMBO Journal
Smith, S M, Larocque, G, Wood, K M, Morris, K L, Roseman, A M, Sessions, R B, Royle, S J & Smith, C J 2021, ' Multi-modal adaptor-clathrin contacts drive coated vesicle assembly ', EMBO Journal, vol. 40, no. 19, e108795, pp. 1-16 . https://doi.org/10.15252/embj.2021108795
Clathrin‐coated pits are formed by the recognition of membrane and cargo by the AP2 complex and the subsequent recruitment of clathrin triskelia. A role for AP2 in coated‐pit assembly beyond initial clathrin recruitment has not been explored. Cla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5e102381816f54d797395af92e6a07d
https://www.research.manchester.ac.uk/portal/en/publications/multimodal-adaptorclathrin-contacts-drive-coated-vesicle-assembly(adc49815-2b9c-4ca1-8234-d3f692865210).html
https://www.research.manchester.ac.uk/portal/en/publications/multimodal-adaptorclathrin-contacts-drive-coated-vesicle-assembly(adc49815-2b9c-4ca1-8234-d3f692865210).html