Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Alan M. Moses"'
Autor:
Yu-Xi Xiao, Seon Yong Lee, Magali Aguilera-Uribe, Reuben Samson, Aaron Au, Yukti Khanna, Zetao Liu, Ran Cheng, Kamaldeep Aulakh, Jiarun Wei, Adrian Granda Farias, Taylor Reilly, Saba Birkadze, Andrea Habsid, Kevin R. Brown, Katherine Chan, Patricia Mero, Jie Qi Huang, Maximilian Billmann, Mahfuzur Rahman, Chad Myers, Brenda J. Andrews, Ji-Young Youn, Christopher M. Yip, Daniela Rotin, W. Brent Derry, Julie D. Forman-Kay, Alan M. Moses, Iva Pritišanac, Anne-Claude Gingras, Jason Moffat
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114417- (2024)
Summary: The ability to sense and respond to osmotic fluctuations is critical for the maintenance of cellular integrity. We used gene co-essentiality analysis to identify an unappreciated relationship between TSC22D2, WNK1, and NRBP1 in regulating ce
Externí odkaz:
https://doaj.org/article/6cfa9d4fad5f4dfe962cefa4d0b2f79f
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 2, Pp 561-570 (2019)
Several examples of transcription factors that show stochastic, unsynchronized pulses of nuclear localization have been described. Here we show that under constant calcium stress, nuclear localization pulses of the transcription factor Crz1 follow st
Externí odkaz:
https://doaj.org/article/c3ea6c6b295d41c0bd45ff2f1a124677
Publikováno v:
BMC Bioinformatics, Vol 19, Iss 1, Pp 1-15 (2018)
Abstract Background Crm1-dependent Nuclear Export Signals (NESs) are clusters of alternating hydrophobic and non-hydrophobic amino acid residues between 10 to 15 amino acids in length. NESs were largely thought to follow simple consensus patterns, ba
Externí odkaz:
https://doaj.org/article/804e16d80f374c8fb4829b7c9e6b17c0
Autor:
Ji-Young Youn, Helena Friesen, Alex N. Nguyen Ba, Wendy Liang, Vincent Messier, Mike J. Cox, Alan M. Moses, Brenda Andrews
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 7, Iss 3, Pp 911-921 (2017)
Kinases and transcription factors (TFs) are key modulators of important signaling pathways and their activities underlie the proper function of many basic cellular processes such as cell division, differentiation, and development. Changes in kinase a
Externí odkaz:
https://doaj.org/article/bb4fa5f0741545718cc5e2bad10e1eff
Publikováno v:
Entropy, Vol 21, Iss 7, p 662 (2019)
Bioinformatics and biophysical studies of intrinsically disordered proteins and regions (IDRs) note the high entropy at individual sequence positions and in conformations sampled in solution. This prevents application of the canonical sequence-struct
Externí odkaz:
https://doaj.org/article/0c33bbf4540c4c78991b08e2ddcbad8d
Algorithms for computational protein design usually begin with a 3D structure and design an amino acid sequence that will fold into that structure. Since intrinsically disordered protein regions lack stable 3D structures, strategies for their design
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::590d54c42aac705f74588963f59cdb52
https://doi.org/10.1101/2023.04.28.538739
https://doi.org/10.1101/2023.04.28.538739
Here we frame the cis-regulatory code (that connects the regulatory functions of non-coding regions, such as promoters and UTRs, to their DNA sequences) as a representation building problem. Representation learning has emerged as a new approach to un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7bc88661350fcbafe22070865d04d3b
https://doi.org/10.1101/2023.04.09.536185
https://doi.org/10.1101/2023.04.09.536185
Autor:
Sean R. Millar, Jie Qi Huang, Karl J. Schreiber, Yi-Cheng Tsai, Jiyun Won, Jianping Zhang, Alan M. Moses, Ji-Young Youn
Publikováno v:
Chemical Reviews.
Autor:
Erin E. Duffy, Benjamin Finander, GiHun Choi, Ava C. Carter, Iva Pritisanac, Aqsa Alam, Victor Luria, Amir Karger, William Phu, Maxwell A. Sherman, Elena G. Assad, Naomi Pajarillo, Alexandra Khitun, Elizabeth E. Crouch, Sanika Ganesh, Jin Chen, Bonnie Berger, Nenad Sestan, Anne O’Donnell-Luria, Eric J. Huang, Eric C. Griffith, Julie D. Forman-Kay, Alan M. Moses, Brian T. Kalish, Michael E. Greenberg
Publikováno v:
Nature neuroscience, vol 25, iss 10
The precise regulation of gene expression is fundamental to neurodevelopment, plasticity and cognitive function. Although several studies have profiled transcription in the developing human brain, there is a gap in understanding of accompanying trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51f1812dea783a335dcb51a8256cbbf1
https://escholarship.org/uc/item/6gc2q79k
https://escholarship.org/uc/item/6gc2q79k
Autor:
Ian S. Hsu, Alan M. Moses
Publikováno v:
The FEBS Journal. 289:647-658
Although the quantity and quality of single-cell data have progressed rapidly, making quantitative predictions with single-cell stochastic models remains challenging. The stochastic nature of cellular processes leads to at least three challenges in b