Zobrazeno 1 - 10 of 116 pro vyhledávání: '"Alan M. Kaplan"'
1
Akademický článek
Toward a molecular pathogenic pathway for Yersinia pestis YopM
Autor: Annette M. Uittenbogaard, R. Lakshman Chelvarajan, Tanya eMyers-Morales, Amanda A. Gorman, W. June Brickey, Zhan eYe, Alan M. Kaplan, Donald A. Cohen, Jenny P.-Y. Ting, Susan C. Straley
Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 2 (2012)
YopM is one of the six effector Yops of the human-pathogenic Yersinia, but its mechanism has not been defined. After delivery to J774A.1 monocyte-like cells, YopM can rapidly bind and activate the serine/threonine kinases RSK1 and PRK2. However, in i
Externí odkaz: https://doaj.org/article/137463cd821e4008999c8df2193823b3
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4
Data from A Critical Role for the Inflammatory Response in a Mouse Model of Preneoplastic Progression
Autor: Jeffrey M. Rosen, Donald A. Cohen, Sandra H. Burnett, Alan M. Kaplan, Wa Xian, Kathryn L. Schwertfeger
The tumor microenvironment, which includes inflammatory cells, vasculature, extracellular matrix, and fibroblasts, is a critical mediator of neoplastic progression and metastasis. Using an inducible transgenic mouse model of preneoplastic progression
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ee0d34fddcae98048041bb8baf03965
https://doi.org/10.1158/0008-5472.c.6494475.v1
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5
Akademický článek
Caspase-3 mediates the pathogenic effect of Yersinia pestis YopM in liver of C57BL/6 mice and contributes to YopM's function in spleen.
Autor: Zhan Ye, Amanda A Gorman, Annette M Uittenbogaard, Tanya Myers-Morales, Alan M Kaplan, Donald A Cohen, Susan C Straley
Publikováno v: PLoS ONE, Vol 9, Iss 11, p e110956 (2014)
The virulence protein YopM of the plague bacterium Yersinia pestis has different dominant effects in liver and spleen. Previous studies focused on spleen, where YopM inhibits accumulation of inflammatory dendritic cells. In the present study we focus
Externí odkaz: https://doaj.org/article/0cd27ae7bd4947d792edf4b54f9405de
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6
Anti-IL-23p19 therapy inhibits the adoptive transfer of syngeneic graft-versus-host disease
Autor: C. Darrell Jennings, Alan M. Kaplan, J. Scott Bryson, J. Anthony Brandon
Publikováno v: Cytokine. 61:732-735
Syngeneic graft-versus-host disease (SGVHD), a chronic inflammatory disease, develops following irradiation, syngeneic bone marrow transplantation (BMT) and treatment with the immunosuppressive agent cyclosporine A (CsA). We have shown that TH1 and T
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01c823aac8dbc47641b55a1f9d7e3e7d
https://doi.org/10.1016/j.cyto.2013.01.005
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7
Role of Oxidative Stress in the Colonic Complications of Murine Syngeneic Graft-versus-host Disease
Autor: Donald A. Cohen, Jacqueline Perez, Alan M. Kaplan, J. Scott Bryson, C. Darrell Jennings, J. Anthony Brandon
Publikováno v: The Open Nitric Oxide Journal. 3:72-80
Syngeneic graft-versus-host disease (SGVHD) develops in mice following lethal irradiation, reconstitution with syngeneic bone marrow (BM) and treatment with a short course of the immunosuppressive agent cyclosporine A (CsA). The development of SGVHD
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a31249154c908ea8908aca581fa7282
https://doi.org/10.2174/1875042701103010072
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8
Development of a TH17 immune response during the induction of murine syngeneic graft-versus-host disease
Autor: Alan M. Kaplan, C. Darrell Jennings, J. Anthony Brandon, J. Scott Bryson
Publikováno v: Cytokine. 52:265-273
Syngeneic graft-versus-host disease (SGVHD) develops following lethal irradiation, reconstitution with syngeneic bone marrow (BM) and treatment with a 21 day course of the immunosuppressive agent cyclosporine A (CsA). Clinical symptoms of SGVHD appea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::894fe999cd64625cec812bd99e371319
https://doi.org/10.1016/j.cyto.2010.08.006
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9
Association between chronic liver and colon inflammation during the development of murine syngeneic graft-versus-host disease
Autor: C. Darrell Jennings, J. Scott Bryson, Subbarao Bondada, Donald A. Cohen, Jacqueline Perez, Vishal J. Sindhava, Alan M. Kaplan, J. Anthony Brandon
Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 299:G602-G613
The murine model of cyclosporine A (CsA)-induced syngeneic graft-versus-host disease (SGVHD) is a bone marrow (BM) transplantation model that develops chronic colon inflammation identical to other murine models of CD4+T cell-mediated colitis. Interes
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccc55a9d8d4097f3e49633aff9f3917b
https://doi.org/10.1152/ajpgi.00511.2009
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10
Gr1+Cells Control Growth of YopM-NegativeYersinia pestisduring Systemic Plague
Autor: Alan M. Kaplan, Nico van Rooijen, Susan C. Straley, Zhan Ye, Edward J. Kerschen, Donald A. Cohen
Publikováno v: Ye, Z, Kerschen, E J, Cohen, D, Kaplan, A M, van Rooijen, N & Straley, S C 2009, ' Gr1(+) Cells Control Growth of YopM-Negative Yersinia pestis during Systemic Plague ', Infection and Immunity, vol. 77, no. 9, pp. 3791-3806 . https://doi.org/10.1128/IAI.00284-09
Infection and Immunity, 77(9), 3791-3806. American Society for Microbiology
YopM, a protein toxin ofYersinia pestis, is necessary for virulence in a mouse model of systemic plague. We previously reported YopM-dependent natural killer (NK) cell depletion from blood and spleen samples of infected mice. However, in this study w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd4dfcb373aee81effe00e81e46502cb
https://doi.org/10.1128/iai.00284-09
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