Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Alan M. Hyde"'
Autor:
Peter E. Maligres, Feng Peng, Ralph Calabria, Louis-Charles Campeau, Wenyong Chen, Peter G. Dormer, Meredith Green, Cyndi Qixin He, Alan M. Hyde, Artis Klapars, Mona Utne Larsen, John Limanto, Guiquan Liu, Yizhou Liu, Aaron Moment, Timothy Nowak, Rebecca T. Ruck, Michael Shevlin, Zhiguo Jake Song, Lushi Tan, Weidong Tong, Jacob H. Waldman, Honglin Ye, Ralph Zhao, George Zhou, Michael A. Zompa, Susan L. Zultanski
Publikováno v:
Organic Process Research & Development. 26:2728-2738
Publikováno v:
Synlett. 32:192-196
The ability of maleate half-ester salts to serve as electrophilic partners in 1,4-conjugate addition reactions with control of regioselectivity has previously been explored in only a limited context with soft nucleophiles. We have demonstrated that b
Publikováno v:
Organic Process Research & Development. 23:1860-1871
The widespread use of amidine and guanidine bases in synthetic chemistry merits a thorough understanding of their chemical properties. The propensity of these reagents to hydrolyze under mild condi...
Autor:
Kevin R. Campos, Lushi Tan, Daniel A. DiRocco, Tyler A. Davis, Rebecca T. Ruck, Peter E. Maligres, Artis Klapars, John Y. L. Chung, Zhiguo Jake Song, Mona Utne Larsen, Wenyong Chen, Timothy J. Wright, Amude M. Kassim, Guiquan Liu, John Limanto, Aaron Moment, Stephen M. Dalby, Susan L. Zultanski, Louis-Charles Campeau, Ralph Calabria, Michael Shevlin, Feng Peng, Bryon Simmons, Alan M. Hyde
Publikováno v:
Chemical Science
An efficient route to the HCV antiviral agent uprifosbuvir was developed in 5 steps from readily available uridine in 50% overall yield. This concise synthesis was achieved by development of several synthetic methods: (1) complexation-driven selectiv
Autor:
Steven F. Oliver, Eric R. Ashley, Christopher Wise, Robert K. Orr, Eric B. Sirota, Rebecca T. Ruck, Joseph F. Leone, Jamie M. McCabe Dunn, Andrew Nolting, Andrew W. Gibson, Alan M. Hyde, Jon A. Jurica
Publikováno v:
Green Chemistry. 20:2519-2525
Herein we describe the route scouting and process development efforts toward a green and sustainable synthesis of the HCV NS5b cyclic prodrug nucleoside (CPN) 1. Through the discovery and development of a crystallization-induced dynamic resolution an
Publikováno v:
Journal of the American Chemical Society. 139:12299-12309
An investigation of the mechanism of benzoic acid/thiourea co-catalysis in the asymmetric Pictet–Spengler reaction is reported. Kinetic, computational, and structure–activity relationship studies provide evidence that rearomatization via deproton
Autor:
Michael Shevlin, Yong-Li Zhong, Alan M. Hyde, Jacob H. Waldman, Feng Peng, Susan L. Zultanski
Publikováno v:
Organic Process Research & Development. 21:1355-1370
Overarching principles for salting-out extraction are long-established but poorly disseminated. We highlight the opportunity for more widespread application of this technique using the Hofmeister series as a foundational basis for choosing the right
Autor:
Nobuyoshi Yasuda, Jiajing Tan, Edward C. Sherer, Alan M. Hyde, Cyndi Qixin He, Andrew Brunskill, Kendall N. Houk, Yu-hong Lam, Adam Simon
Publikováno v:
The Journal of Organic Chemistry. 82:8645-8650
A model for the stereoselectivity of intramolecular alkylations by N,N'-disubstituted cinchona alkaloids reported by Xiang et al. was established using density functional theory (DFT) calculations. The stereocontrol is based on the minimal distortion
Autor:
Daniel A. DiRocco, Yining Ji, Rebecca T. Ruck, Ian W. Davies, Edward C. Sherer, Alan M. Hyde, Mikhail Reibarkh, Louis-Charles Campeau, Peter E. Maligres, Andrew Brunskill, James F. Dropinski, Rose Mathew, Artis Klapars, John Limanto
Publikováno v:
Science. 356:426-430
Getting phosphorus into healthy shape ProTide therapeutics play a trick on the body, getting nucleoside analogs where they need to be by decorating them with unnatural phosphoramidates in place of ordinary phosphates. These compounds pose an unusual
Autor:
Hongming Li, R. Thomas Williamson, Edward C. Sherer, Andrew Brunskill, Kevin M. Belyk, Ian W. Davies, Louis-Charles Campeau, Rebecca T. Ruck, Katrina W. Lexa, Sumei Ren, Jingjun Yin, Qinghao Chen, Yining Ji, Alan M. Hyde
Publikováno v:
Chemical Science. 8:2841-2851
Significant catalyst loading reduction and increased reaction robustness have been achieved for a Pd-catalyzed asymmetric intramolecular C–N coupling through comprehensive mechanistic studies. Detailed kinetic, spectroscopic, and crystallographic a