Zobrazeno 1 - 5
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pro vyhledávání: '"Alan M. Hebert"'
Publikováno v:
Genes & Development. 26:2709-2723
The ability to generate asymmetry at the cell cortex underlies cell polarization and asymmetric cell division. Here we demonstrate a novel role for the tumor suppressor Merlin and closely related ERM proteins (Ezrin, Radixin, and Moesin) in generatin
Publikováno v:
Developmental Cell. 19:727-739
SummaryThe neurofibromatosis type 2 (NF2) tumor suppressor, Merlin, is a FERM (Four point one, Ezrin, Radixin, Moesin) domain-containing protein whose loss results in defective morphogenesis and tumorigenesis in multiple tissues. Like the closely rel
Autor:
Tali Mazor, Alan M. Hebert, Andrew G. Howe, Debabrata RayChaudhuri, Sameer Urgaonkar, Peter A. Wood, Carolyn A. Robinson, Jared T. Shaw, Shubhasish Mukherjee
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:6651-6655
A new small molecule inhibitor of bacterial cell division has been discovered using a high-throughput screen in Escherichia coli . Although the lead screening hit ( 534F6 ) exhibited modest inhibition of the GTPase activity of FtsZ (20 ± 5% at 100
Autor:
Alan M. Hebert, Rebecca B. Mets, Debabrata RayChaudhuri, Danielle N. Margalit, Timothy J. Mitchison, Marc W. Kirschner, Laura Romberg
Publikováno v:
Proceedings of the National Academy of Sciences. 101:11821-11826
FtsZ, the ancestral homolog of eukaryotic tubulins, is a GTPase that assembles into a cytokinetic ring structure essential for cell division in prokaryotic cells. Similar to tubulin, purified FtsZ polymerizes into dynamic protofilaments in the presen
Autor:
Marc W. Kirschner, Danielle N. Margalit, Alan M. Hebert, Rebecca B. Mets, Laura Romberg, Debabrata RayChaudhuri, Timothy J. Mitchison
Publikováno v:
Proceedings of the National Academy of Sciences. 101:13969-13969