Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Alan M Moses"'
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 9, p e1010452 (2022)
Constraint-based modeling is a powerful framework for studying cellular metabolism, with applications ranging from predicting growth rates and optimizing production of high value metabolites to identifying enzymes in pathogens that may be targeted fo
Externí odkaz:
https://doaj.org/article/cc75f290167c4c51a45f3eb41448544c
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 6, p e1010238 (2022)
A major challenge to the characterization of intrinsically disordered regions (IDRs), which are widespread in the proteome, but relatively poorly understood, is the identification of molecular features that mediate functions of these regions, such as
Externí odkaz:
https://doaj.org/article/cb97a63ed41d4fd2a040177bf0b5297a
Publikováno v:
PLoS Genetics, Vol 17, Iss 9, p e1009629 (2021)
Stochastic signaling dynamics expand living cells' information processing capabilities. An increasing number of studies report that regulators encode information in their pulsatile dynamics. The evolutionary mechanisms that lead to complex signaling
Externí odkaz:
https://doaj.org/article/fc43d48845f1409795c80b3a2d11b345
Publikováno v:
eLife, Vol 10 (2021)
In previous work, we showed that intrinsically disordered regions (IDRs) of proteins contain sequence-distributed molecular features that are conserved over evolution, despite little sequence similarity that can be detected in alignments (Zarin et al
Externí odkaz:
https://doaj.org/article/a6e4dce7bd0e4410a47cefd1282bcbdc
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 9, p e1007348 (2019)
Cellular microscopy images contain rich insights about biology. To extract this information, researchers use features, or measurements of the patterns of interest in the images. Here, we introduce a convolutional neural network (CNN) to automatically
Externí odkaz:
https://doaj.org/article/687354cd37c843249bb050c254ef608f
Publikováno v:
eLife, Vol 8 (2019)
Intrinsically disordered regions make up a large part of the proteome, but the sequence-to-function relationship in these regions is poorly understood, in part because the primary amino acid sequences of these regions are poorly conserved in alignmen
Externí odkaz:
https://doaj.org/article/1ef704afc0bf411db20f5fbcef6b58fb
Autor:
Alex X Lu, Yolanda T Chong, Ian Shen Hsu, Bob Strome, Louis-Francois Handfield, Oren Kraus, Brenda J Andrews, Alan M Moses
Publikováno v:
eLife, Vol 7 (2018)
The evaluation of protein localization changes on a systematic level is a powerful tool for understanding how cells respond to environmental, chemical, or genetic perturbations. To date, work in understanding these proteomic responses through high-th
Externí odkaz:
https://doaj.org/article/53a7eae98e7f4b198f6b9657f1119bc4
Publikováno v:
PLoS Genetics, Vol 13, Iss 4, p e1006735 (2017)
Regulatory networks often increase in complexity during evolution through gene duplication and divergence of component proteins. Two models that explain this increase in complexity are: 1) adaptive changes after gene duplication, such as resolution o
Externí odkaz:
https://doaj.org/article/f0ef18ca1ff94da990049a0607b78b52
Autor:
Alex Xijie Lu, Alan M Moses
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0158712 (2016)
Despite the importance of characterizing genes that exhibit subcellular localization changes between conditions in proteome-wide imaging experiments, many recent studies still rely upon manual evaluation to assess the results of high-throughput imagi
Externí odkaz:
https://doaj.org/article/dc82daf7dffe4ea3a312782dfc253059
Autor:
Gergő Gógl, Kyle D Schneider, Brian J Yeh, Nashida Alam, Alex N Nguyen Ba, Alan M Moses, Csaba Hetényi, Attila Reményi, Eric L Weiss
Publikováno v:
PLoS Biology, Vol 13, Iss 5, p e1002146 (2015)
Eukaryotic cells commonly use protein kinases in signaling systems that relay information and control a wide range of processes. These enzymes have a fundamentally similar structure, but achieve functional diversity through variable regions that dete
Externí odkaz:
https://doaj.org/article/31471c17669943c58389a0fa123abf73