Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Alan M Michelson"'
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141066 (2015)
Here we used predictive gene expression signatures within a multi-species framework to identify the genes that underlie cardiac cell fate decisions in differentiating embryonic stem cells. We show that the overlapping orthologous mouse and human gene
Externí odkaz:
https://doaj.org/article/ac30b911907a4231bd4d5d0b15bb07ee
Autor:
Brian W Busser, Stephen S Gisselbrecht, Leila Shokri, Terese R Tansey, Caitlin E Gamble, Martha L Bulyk, Alan M Michelson
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69385 (2013)
Homeodomain (HD) proteins are a large family of evolutionarily conserved transcription factors (TFs) having diverse developmental functions, often acting within the same cell types, yet many members of this family paradoxically recognize similar DNA
Externí odkaz:
https://doaj.org/article/ae3415d4afba4ec79cbd98334d7707cd
Autor:
Brian W Busser, Leila Taher, Yongsok Kim, Terese Tansey, Molly J Bloom, Ivan Ovcharenko, Alan M Michelson
Publikováno v:
PLoS Genetics, Vol 8, Iss 3, p e1002531 (2012)
Transcriptional enhancers integrate the contributions of multiple classes of transcription factors (TFs) to orchestrate the myriad spatio-temporal gene expression programs that occur during development. A molecular understanding of enhancers with sim
Externí odkaz:
https://doaj.org/article/c6f346954ed147bb906afc571c06c170
Autor:
Anthony A Philippakis, Brian W Busser, Stephen S Gisselbrecht, Fangxue Sherry He, Beatriz Estrada, Alan M Michelson, Martha L Bulyk
Publikováno v:
PLoS Computational Biology, Vol 2, Iss 5, p e53 (2006)
While combinatorial models of transcriptional regulation can be inferred for metazoan systems from a priori biological knowledge, validation requires extensive and time-consuming experimental work. Thus, there is a need for computational methods that
Externí odkaz:
https://doaj.org/article/15a5874a0a4a422197c9547317d96a8f
Autor:
Beatriz Estrada, Sung E Choe, Stephen S Gisselbrecht, Sebastien Michaud, Lakshmi Raj, Brian W Busser, Marc S Halfon, George M Church, Alan M Michelson
Publikováno v:
PLoS Genetics, Vol 2, Iss 2, p e16 (2006)
An important but largely unmet challenge in understanding the mechanisms that govern the formation of specific organs is to decipher the complex and dynamic genetic programs exhibited by the diversity of cell types within the tissue of interest. Here
Externí odkaz:
https://doaj.org/article/d67d84d924ac42b0a755d3eb45df2677
Publikováno v:
Nucleic Acids Research
Here we used discriminative training methods to uncover the chromatin, transcription factor (TF) binding and sequence features of enhancers underlying gene expression in individual cardiac cells. We used machine learning with TF motifs and ChIP data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5134074500c8cb321bb5fd3683f6e829
https://doi.org/10.1093/nar/gkv011
https://doi.org/10.1093/nar/gkv011
Autor:
Alan M. Michelson, Terese Tansey, Michael T. Nolte, Shaad M. Ahmad, Stephen S. Gisselbrecht, Nasser M. Rusan, Neal Jeffries, Brian W. Busser
Publikováno v:
Developmental Cell. 23(1):97-111
The development of a complex organ requires the specification of appropriate numbers of each of its constituent cell types, as well as their proper differentiation and correct positioning relative to each other. During Drosophila cardiogenesis, all t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::790d8ca7163b87e3db281af86c1eee3b
Autor:
Adrian D. Haimovich, Brian W. Busser, Xianmin Zhu, Alan M. Michelson, Yongsok Kim, Neal Jeffries, Martha L. Bulyk, Anton Aboukhalil, Shaad M. Ahmad, Terese Tansey
Publikováno v:
Development (Cambridge, England)
A common theme in developmental biology is the repeated use of the same gene in diverse spatial and temporal domains, a process that generally involves transcriptional regulation mediated by multiple separate enhancers, each with its own arrangement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cfc1da6c604ca85a4377d62a48f3403
https://doi.org/10.1242/dev.069005
https://doi.org/10.1242/dev.069005
Autor:
Savina Jaeger, Brian W. Busser, Aditi Singhania, Michael F. Berger, Martha L. Bulyk, Stephen S. Gisselbrecht, Bo Zhou, Leila Shokri, Alan M. Michelson
Publikováno v:
Development (Cambridge, England)
A subfamily of Drosophila homeodomain (HD) transcription factors (TFs) controls the identities of individual muscle founder cells (FCs). However, the molecular mechanisms by which these TFs generate unique FC genetic programs remain unknown. To inves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ef5f43a414ddeef0fda97c6c29887d5
https://doi.org/10.1242/dev.077362
https://doi.org/10.1242/dev.077362
Autor:
Stephen S. Gisselbrecht, Alan M. Michelson, Neal Jeffries, Shaad M. Ahmad, Pritha Bhattacharyya
Publikováno v:
Development (Cambridge, England)
Cardiogenesis involves the coordinated regulation of multiple biological processes by a finite set of transcription factors (TFs). Here, we show that the Forkhead TFs Checkpoint suppressor homologue (CHES-1-like) and Jumeau (Jumu), which govern cardi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e04971bd0f5467256e03075f17efaf86
https://pubmed.ncbi.nlm.nih.gov/26657774
https://pubmed.ncbi.nlm.nih.gov/26657774