Zobrazeno 1 - 10
of 197
pro vyhledávání: '"Alan Lichtenstein"'
Autor:
Angelica Benavides-Serrato, Jihye Lee, Brent Holmes, Kenna A Landon, Tariq Bashir, Michael E Jung, Alan Lichtenstein, Joseph Gera
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0212160 (2019)
[This corrects the article DOI: 10.1371/journal.pone.0176599.].
Externí odkaz:
https://doaj.org/article/6135fc6ac3384c2cb1bc61b7bb8498c8
Autor:
Angelica Benavides-Serrato, Jacquelyn T. Saunders, Brent Holmes, Robert N. Nishimura, Alan Lichtenstein, Joseph Gera
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 1, p 344 (2020)
Internal ribosome entry site (IRES)-mediated protein synthesis has been demonstrated to play an important role in resistance to mechanistic target of rapamycin (mTOR) targeted therapies. Previously, we have demonstrated that the IRES trans-acting fac
Externí odkaz:
https://doaj.org/article/2b6e47cfebdc4f6bb9e3cb2c7dd72784
Autor:
Angelica Benavides-Serrato, Jihye Lee, Brent Holmes, Kenna A Landon, Tariq Bashir, Michael E Jung, Alan Lichtenstein, Joseph Gera
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0176599 (2017)
A small molecule which specifically blocks the interaction of Rictor and mTOR was identified utilizing a high-throughput yeast two-hybrid screen and evaluated as a potential inhibitor of mTORC2 activity in glioblastoma multiforme (GBM). In vitro, CID
Externí odkaz:
https://doaj.org/article/dfba5d1f920047d6a7daff473ec6327c
Autor:
Yijiang Shi, Patrick Frost, Bao Hoang, Yonghui Yang, Carolyne Bardeleben, Joseph Gera, Alan Lichtenstein
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94011 (2014)
Because multiple myeloma (MM) cells are at risk for endoplasmic reticulum (ER) stress, they require a carefully regulated mechanism to promote protein translation of selected transcripts when proliferation is stimulated. MAPK-interacting kinases (MNK
Externí odkaz:
https://doaj.org/article/afbb6a8ed1804a6b8aca5b065b7ec90c
Autor:
Alan Lichtenstein, Carolyne Bardeleben, Veena Mysore, Patrick J. Frost, Yijiang Shi, Bao Hoang
Suppl fig 7: A) MM1.S MM cells transfected with empty vector (ev) or wild type SGK (sgk) subsequently treated with 0, 10 or 20 nM Bortezomib for 8 hrs followed by immunoblot assay.; B) MM cells uninfected (par=parental) or infected with shRNA targeti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34078e49608ae84c4431aa198eac82d1
https://doi.org/10.1158/1541-7786.22514134
https://doi.org/10.1158/1541-7786.22514134
Autor:
Joseph Gera, Alan Lichtenstein, Janine Masri, Lauren Anderson, Teresa Ruegg, Nicholas Artinian, Brent Holmes, Tariq Bashir, Andrew Bernath, Cheri Cloninger
A variety of mechanisms confer hypersensitivity of tumor cells to the macrolide rapamycin, the prototypic mTORC1 inhibitor. Several studies have shown that the status of the AKT kinase plays a critical role in determining hypersensitivity. Cancer cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93ab69775d46fd3d83a1f2aad6c02274
https://doi.org/10.1158/1535-7163.c.6535204
https://doi.org/10.1158/1535-7163.c.6535204
Autor:
Alan Lichtenstein, Joseph F. Gera, Michael E. Jung, Jihye Lee, Rogelio Hernandez-Pando, Gabriela Antonio-Andres, Sara Huerta-Yepez, Patrick Frost, Yijiang Shi, Mario I. Vega
Prior work indicates DEPTOR expression in multiple myeloma cells could be a therapeutic target. DEPTOR binds to mTOR via its PDZ domain and inhibits mTOR kinase activity. We previously identified a drug, which prevented mTOR–DEPTOR binding (NSC1264
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2059020c921a01df6787589792c87af8
https://doi.org/10.1158/1535-7163.c.6537720.v1
https://doi.org/10.1158/1535-7163.c.6537720.v1
Autor:
Alan Lichtenstein, Joseph F. Gera, Michael E. Jung, Jihye Lee, Rogelio Hernandez-Pando, Gabriela Antonio-Andres, Sara Huerta-Yepez, Patrick Frost, Yijiang Shi, Mario I. Vega
Suppl fig 6: Immunocompetent non-tumor bearing mice injected IP daily with increasing concentrations of drug 3g for 21 days followed by harvest of serum for assays of alkaline phosphatase, ALT, AST, bilirubin and BUN. Chemistry values of control mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dbe87cdf5a9d1eff4590ac68322ad8e
https://doi.org/10.1158/1535-7163.22504392
https://doi.org/10.1158/1535-7163.22504392
E-cadherin is an important tumor suppressor gene whose expression is lost when cells acquire a metastatic phenotype. We analyzed the role of E-cadherin missplicing as a mechanism of its downregulation by analyzing a misspliced E-cadherin transcript t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d3098e3b0882f22565625b59a5bc54c
https://doi.org/10.1158/1535-7163.c.6535474
https://doi.org/10.1158/1535-7163.c.6535474
Autor:
Alan Lichtenstein, Yijiang Shi, Bao Hoang, Patrick Frost, Sara Bassilian, Joseph R. Reeve, Sanjai Sharma, Carolyne Bardeleben
PDF file - 82K, Cell cycle analysis of cells treated with AICAr in the presence or absence of uridine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b8e7e86fdfe5eb830a83bde205b7d66
https://doi.org/10.1158/1535-7163.22500717
https://doi.org/10.1158/1535-7163.22500717