Zobrazeno 1 - 10
of 214
pro vyhledávání: '"Alan Lau"'
Autor:
Elizabeth L. Hardaker, Emilio Sanseviero, Ankur Karmokar, Devon Taylor, Marta Milo, Chrysis Michaloglou, Adina Hughes, Mimi Mai, Matthew King, Anisha Solanki, Lukasz Magiera, Ricardo Miragaia, Gozde Kar, Nathan Standifer, Michael Surace, Shaan Gill, Alison Peter, Sara Talbot, Sehmus Tohumeken, Henderson Fryer, Ali Mostafa, Kathy Mulgrew, Carolyn Lam, Scott Hoffmann, Daniel Sutton, Larissa Carnevalli, Fernando J. Calero-Nieto, Gemma N. Jones, Andrew J. Pierce, Zena Wilson, David Campbell, Lynet Nyoni, Carla P. Martins, Tamara Baker, Gilberto Serrano de Almeida, Zainab Ramlaoui, Abdel Bidar, Benjamin Phillips, Joseph Boland, Sonia Iyer, J. Carl Barrett, Arsene-Bienvenu Loembé, Serge Y. Fuchs, Umamaheswar Duvvuri, Pei-Jen Lou, Melonie A. Nance, Carlos Alberto Gomez Roca, Elaine Cadogan, Susan E. Critichlow, Steven Fawell, Mark Cobbold, Emma Dean, Viia Valge-Archer, Alan Lau, Dmitry I. Gabrilovich, Simon T. Barry
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The Ataxia telangiectasia and Rad3-related (ATR) inhibitor ceralasertib in combination with the PD-L1 antibody durvalumab demonstrated encouraging clinical benefit in melanoma and lung cancer patients who progressed on immunotherapy. Here we
Externí odkaz:
https://doaj.org/article/189773f2417346dcbdf8b6281d57effa
Autor:
Matthew King, Dmitry Gabrilovich, Simon Barry, Mark Cobbold, Viia Valge-Archer, Adina Hughes, Elizabeth Hardaker, Alison Peter, Anisha Solanki, Lukasz Magiera, Gozde Kar, Stephen Fawell, Ankur Karmokar, Marta Milo, Chrysiis Michaloglou, Ricardo Miragaia, Sara Talbot, Carolyn Lam, Daniel Sutton, Scott Hoffmann, Larissa Carnevalli, Zena Wilson, Alan Lau
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/4011e2f43eec424c8619525f52d29501
Autor:
Ankur Karmokar, Rebecca Sargeant, Adina M. Hughes, Hana Baakza, Zena Wilson, Sara Talbot, Sarah Bloomfield, Elisabetta Leo, Gemma N. Jones, Maria Likhatcheva, Luis Tobalina, Emma Dean, Elaine B. Cadogan, Alan Lau
Publikováno v:
Cancers, Vol 15, Iss 16, p 4195 (2023)
Ataxia-telangiectasia mutated gene (ATM) is a key component of the DNA damage response (DDR) and double-strand break repair pathway. The functional loss of ATM (ATM deficiency) is hypothesised to enhance sensitivity to DDR inhibitors (DDRi). Whole-ex
Externí odkaz:
https://doaj.org/article/55a888fddaa1462f828520921c2b9414
Autor:
Tudor Petreus, Elaine Cadogan, Gareth Hughes, Aaron Smith, Venkatesh Pilla Reddy, Alan Lau, Mark James O’Connor, Susan Critchlow, Marianne Ashford, Lenka Oplustil O’Connor
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Petreus et al. describe a platform combining 3D tumour-on-chip technology and pump driven microfluidics to study drug effects at physiological exposures preclinically. They test colorectal cancer spheroids with combinations of two drugs and show that
Externí odkaz:
https://doaj.org/article/fe393dff3e4d4995a5151b725bf099ec
Autor:
Timothy I. Johnson, Christopher J. Minteer, Daniel Kottmann, Charles R. Dunlop, Sandra Bernaldo de Quirós Fernández, Larissa S. Carnevalli, Yann Wallez, Alan Lau, Frances M. Richards, Duncan I. Jodrell
Publikováno v:
EBioMedicine, Vol 68, Iss , Pp 103396- (2021)
Background: Chemotherapy and targeted agent anti-cancer efficacy is largely dependent on the proliferative state of tumours, as exemplified by agents that target DNA synthesis/replication or mitosis. As a result, cell cycle specificities of a number
Externí odkaz:
https://doaj.org/article/4408046a6c6241ba8f27a66d0de90ae8
Autor:
Janis Vella, Maresca Attard Pizzuto, Nicolette Sammut Bartolo, Francesca Wirth, Louise Grech, Jennifer Pham, Christina Mactal Haaf, Alan Lau, Anthony Serracino Inglott, Lilian M. Azzopardi
Publikováno v:
MedEdPublish, Vol 10, Iss 1 (2021)
Background A three-year post-graduate international Doctorate in Pharmacy collaborative course, was launched by the Department of Pharmacy, University of Malta in collaboration with the College of Pharmacy, University of Illinois at Chicago. Aim a
Externí odkaz:
https://doaj.org/article/a498068d54a94b328a716d9cbb329ded
Autor:
Jong Hak Kim, Alan Lau
Selected peer-reviewed extended papers abstracts of which were presented at the 7th International Conference on Composite Materials and Material Engineering (ICCMME), and the 12th International Conference on Advanced Materials Research (ICAMR)Aggrega
This volume of'Engineering Innovations'presents research results on materials properties and their processing technologies, reliability of technological equipment and machines, and technologies of unit reconditioning. Readers can also look at the res
Autor:
Yung-Jue Bang, Mark J. O'Connor, Alan Lau, Jeff Brown, Do-Youn Oh, Tae-Yong Kim, Jin Won Kim, Kyung-Hun Lee, Hee-Jun Kim, Yaewon Yang, Debora Keunyoung Kim, Miso Lee, Seongyeong Kim, Hyemin Jang, Seock-Ah Im, Ahrum Min
Conflict of Interest Form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::146122d7bd6bf8c8ee659602acf859b1
https://doi.org/10.1158/1535-7163.22507636
https://doi.org/10.1158/1535-7163.22507636
Autor:
Sven Rottenberg, Jos Jonkers, Piet Borst, Shridar Ganesan, Mark J. O'Connor, Alan Lau, Niall M.B. Martin, Aaron Cranston, James H. Doroshow, Amal Aly, Jiuping Ji, Ellen Wientjens, Rinske Drost, Serge A. Zander, Liesbeth van Deemter, Wendy Sol, Ute Boon, Ariena Kersbergen, Janneke E. Jaspers
PDF file - 1.2MB, This file contains additional data on tumor responses to olaparib treatment (Fig. S1 and S2), pH2AX stainings on treated and untreated tumors (Fig. S3), analysis of mutations in 53BP1 (Fig. S4 and S7B), characterization of cell line
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a652d31d7f726c5046308e033b91f32
https://doi.org/10.1158/2159-8290.22528427.v1
https://doi.org/10.1158/2159-8290.22528427.v1