Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Alan L. Lehman"'
Publikováno v:
Combinatorial Chemistry & High Throughput Screening. 13:422-429
In the one-bead-one-compound (OBOC) combinatorial method, compounds are constructed on bead resin via split-mix library synthesis such that multiple copies of the same compound are displayed on each bead. These libraries are rapidly screened with enz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45eb2d5dd34faf96cc755b816e16c81
https://doi.org/10.2174/138620710791292994
https://doi.org/10.2174/138620710791292994
Publikováno v:
Accounts of Chemical Research. 36:370-377
The "one-bead-one-compound" (OBOC) combinatorial library method synthesizes millions of random compounds such that each bead displays only one compound. Bead libraries are screened, and positive beads are isolated for structure analysis. Peptide subs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e174f6e9df76cb3618cd9e92b4b867e
https://doi.org/10.1021/ar0201299
https://doi.org/10.1021/ar0201299
Publikováno v:
Journal of combinatorial chemistry. 8(4)
To screen one-bead-one-compound (OBOC) combinatorial bead libraries,(1) one generally uses tagged purified protein as the screening probe. Compound beads that interact with the purified protein are then identified, for example, via an enzyme-linked c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40c1b8cc8a535d907f34010268c2c7b7
https://pubmed.ncbi.nlm.nih.gov/16827569
https://pubmed.ncbi.nlm.nih.gov/16827569
Autor:
Alan L. Lehman, Ninh Doan, Ruiwu Liu, Aimin Song, Amanda M. Enstrom, Joeseph Maxwell, Kit S. Lam
Publikováno v:
ChemInform. 36
Publisher Summary In the “one-bead one-compound” (OBOC) combinatorial library method, compound beads are prepared by a “split-mix” synthesis approach that results in the display of many copies of the same compound on one single bead. This cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::849f05f2206dc3b550199b4aaac9d4cb
https://doi.org/10.1002/chin.200504261
https://doi.org/10.1002/chin.200504261
Autor:
Mark J. Kurth, Xin Cong, Sung Hee Hwang, Carlito B. Lebrilla, Kit S. Lam, Marilyn M. Olmstead, Alan L. Lehman
Publikováno v:
Organic letters. 6(21)
[reaction: see text] A bromine-/chlorine-containing mass-tag encoding strategy for a small-molecule OBOC combinatorial library is reported. The resulting MALDI FTMS isotope pattern of each tag clearly defines the component building blocks of each "hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63445f3c8cba64ab74d79f5de2462e5c
https://pubmed.ncbi.nlm.nih.gov/15469360
https://pubmed.ncbi.nlm.nih.gov/15469360
Autor:
Kit S, Lam, Alan L, Lehman, Aimin, Song, Ninh, Doan, Amanda M, Enstrom, Joseph, Maxwell, Ruiwu, Liu
Publikováno v:
Methods in enzymology. 369
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8f2dcaf5babbcb0792dda76add7433f9
https://pubmed.ncbi.nlm.nih.gov/14722961
https://pubmed.ncbi.nlm.nih.gov/14722961
Autor:
Ruiwu Liu, Kit S. Lam, Aimin Song, Alan L. Lehman, Amanda M. Enstrom, Ninh Doan, Joeseph Maxwell
Publisher Summary In the “one-bead one-compound” (OBOC) combinatorial library method, compound beads are prepared by a “split-mix” synthesis approach that results in the display of many copies of the same compound on one single bead. This cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d3b130f14da2d85721905832c95390a
https://doi.org/10.1016/s0076-6879(03)69017-8
https://doi.org/10.1016/s0076-6879(03)69017-8
Autor:
Michael E. Dahmus, Alan L. Lehman
Publikováno v:
The Journal of biological chemistry. 275(20)
The phosphorylation state of the carboxyl-terminal domain (CTD) of the largest RNA polymerase (RNAP) II subunit plays an important role in the regulation of transcript elongation. This report examines the sensitivity of RNAP II to dephosphorylation b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13611027ee713a2c69eea26067c53be3
https://pubmed.ncbi.nlm.nih.gov/10809737
https://pubmed.ncbi.nlm.nih.gov/10809737
Autor:
Alan L. Lehman, Thomas Lehman
Publikováno v:
American Journal of Physics. 56:1046-1047
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88580b3a8d2d106776f0f0c7c6de8aaf
https://doi.org/10.1119/1.15342
https://doi.org/10.1119/1.15342