Výsledky vyhledávání - "Alan L. Hiti"

Successful correction of the human β-thalassemia major phenotype using a lentiviral vector

Autor: Geetha Puthenveetil, Ying Yu, Naveen Qureshi, Ping Xia, Punam Malik, Denysha Carbonell, Licheng Zeng, Alan L Hiti, Jessica Scholes, Jiing-Kuan Yee, Shulian Li

Publikováno v: Blood. 104:3445-3453

beta-thalassemias are the most common single gene disorders and are potentially amenable to gene therapy. However, retroviral vectors carrying the human beta-globin cassette have been notoriously unstable. Recently, considerable progress has been mad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea535745eb1a78219a576673073d8249
https://doi.org/10.1182/blood-2004-04-1427

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Ineffective erythropoiesis in β-thalassemia major is due to apoptosis at the polychromatophilic normoblast stage

Autor: Timothy C. Fisher, Herbert J. Meiselman, Alan L. Hiti, Licheng Zeng, Liesl A Mathias, Punam Malik, Kenneth I. Weinberg

Publikováno v: Experimental Hematology. 28:1343-1353

Beta-thalassemia major is characterized by ineffective erythropoiesis, although it is difficult to define the dynamics of this process from the static information revealed by analysis of bone marrow (BM) aspirates. We aimed to study the kinetics of s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afc7377388fd2c9aa04b9d044e992839
https://doi.org/10.1016/s0301-472x(00)00555-5

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An In Vitro Model of Human Red Blood Cell Production From Hematopoietic Progenitor Cells

Autor: Licheng Zeng, Timothy C. Fisher, Herbert J. Meiselman, Thomas D. Coates, Parvin Izadi, Lora Barsky, Donald B. Kohn, Alan L. Hiti, Punam Malik, Kenneth I. Weinberg

Publikováno v: Blood. 91:2664-2671

Hemoglobinopathies, such as β-thalassemias and sickle cell anemia (SCA), are among the most common inherited gene defects. Novel models of human erythropoiesis that result in terminally differentiated red blood cells (RBCs) would be able to address

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b67f034ef4c31935a6e6f0634608db9
https://doi.org/10.1182/blood.v91.8.2664.2664_2664_2671

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Evidence of a dominant transcriptional pathway which regulates an undifferentiated and complete metastatic phenotype

Autor: Sanford H. Barsky, Mark D. Sternlicht, Joe W. Gray, Suzi Safarians, Sophia D Stewart, Alan L. Hiti, Mai Nguyen, Koei Chin

Publikováno v: Oncogene. 15:2077-2091

The highly metastatic amelanotic C8161 human melanoma line was found to exhibit complete dominance of its undifferentiated and metastatic phenotype in multiple somatic cell hybridization studies designed to bypass the presence of potential tumor supp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8e0ff1aa2ad66667dd4bd4141c19f5e
https://doi.org/10.1038/sj.onc.1201379

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Nonspecific Interstitial Pneumonitis Mimicking Pneumocystis carinii Pneumonia

Autor: Michael Koss, C T Boylen, L Hirano, Fred R. Sattler, L Zeng, C Hughlett, F Hofman, L Nichols, Alan L. Hiti

Publikováno v: American Journal of Respiratory and Critical Care Medicine. 156:912-917

Bronchoalveolar lavage (BAL) and transbronchial biopsies from 351 human immunodeficiency virus (HIV)-positive patients with presumed Pneumocystis pneumonia were analyzed to determine the spectrum and frequency of interstitial lung disease mimicking P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff128961954edb0b477e565ef254d4f0
https://doi.org/10.1164/ajrccm.156.3.9612050

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Beta-globin haplotypes from blood spots for follow-up of newborn hemoglobinopathy screening

Autor: Qing Xiang, Darleen R. Powars, Licheng Zeng, Fred Lorey, Alan L. Hiti

Publikováno v: American Journal of Hematology. 54:76-78

The inheritance of sickle-cell anemia upon the background of the major beta-globin gene cluster haplotypes has been associated with differing risks for major organ failure, and more recently with response to hydroxyurea treatment. Early identificatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3f1c01ca28aa0b187ccc3c4b9a9b6d1
https://doi.org/10.1002/(sici)1096-8652(199701)54:1<76::aid-ajh12>3.0.co

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Outcome of sickle cell anemia: a 4-decade observational study of 1056 patients

Autor: Cage S. Johnson, Linda S. Chan, Alan L. Hiti, Emily Ramicone, Darleen R. Powars

Publikováno v: Medicine. 84(6)

Based on a prospective cohort study of 1056 patients with sickle cell anemia (Hb SS) initiated in 1959, we investigated the influence of calendar era, age, sex, and prior medical conditions on the subsequent development of irreversible organ damage a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c510f2423df6268c197c9fd743d1907
https://pubmed.ncbi.nlm.nih.gov/16267411

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Human CD34(+) and CD34(+)CD38(-) hematopoietic progenitors in sickle cell disease differ phenotypically and functionally from normal and suggest distinct subpopulations that generate F cells

Autor: Licheng Zeng, Kenneth I. Weinberg, Alan L. Hiti, Lori R Luck, Punam Malik

Publikováno v: Experimental hematology. 32(5)

Sickle cell disease (SCD) is remarkable for stress erythropoiesis. We investigated the progenitor populations contributing to erythroid stress.We characterized hematopoietic progenitor cells in sickle bone marrow and sickle peripheral blood from pati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2986c2085b7a2617c10df11518829fbc
https://pubmed.ncbi.nlm.nih.gov/15145217

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