Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Alan K. Mallams"'
Autor:
Bimalendu Dasmahapatra, Doll Ronald J, Cheng Li, Alan K. Mallams, David Hesk, Mark Demma, Robert A. Ramos, Eugene Maxwell, Ming Liu, Cynthia Seidel-Dugan, Lianzhu Liang, W. Robert Bishop, Randall R. Rossman
Publikováno v:
Journal of Biological Chemistry. 285:10198-10212
Abrogation of p53 function occurs in almost all human cancers, with more than 50% of cancers harboring inactivating mutations in p53 itself. Mutation of p53 is indicative of highly aggressive cancers and poor prognosis. The vast majority of mutations
Autor:
Carmen S. Alvarez, Taveras Arthur G, Bancha Vibulbhan, Doll Ronald J, Viyyoor M. Girijavallabhan, Birendra N. Pramanik, Mathew S. Bryant, Donna Carr, Ashit K. Ganguly, Linda James, Alan K. Mallams, Chao Jianping, Adriano Afonso, Jeff Deskus, Ming Liu, Lynn Wang, Randall R. Rossman, Lalwani Tarik, Paul Kirschmeier, Cynthia J. Vaccaro, Larry Heimark, Stacy W. Remiszewski, F. George Njoroge, W. Robert Bishop, Robert Patton, Jocelyn del Rosario, Pat Pinto, and Amin A. Nomeir
Publikováno v:
Journal of Medicinal Chemistry. 42:2651-2661
Farnesyl protein transferase (FPT) is a promising target for the development of cancer chemotherapeutics because it is responsible for the farnesylation of oncogenic p21 Ras proteins which are found in nearly 30% of all human cancers and necessary fo
Autor:
Alan K. Mallams, Randall R. Rossman, Ronald J. Doll, Viyyoor M. Girijavallabhan, Ashit K. Ganguly, Joanne Petrin, Lynn Wang, Robert Patton, W. Robert Bishop, Donna M. Carr, Paul Kirschmeier, Joseph J. Catino, Matthew S. Bryant, Kwang-Jong Chen, Walter A. Korfmacher, Cymbelene Nardo, Shiyong Wang, Amin A. Nomeir, Chin-Chung Lin, Zujun Li, Jianping Chen, Suining Lee, Janet Dell, Philip Lipari, Michael Malkowski, Bodan Yaremko, Ivan King, Ming Liu
Publikováno v:
Journal of Medicinal Chemistry. 41:877-893
The synthesis of a variety of novel 4-amido, 4-carbamoyl and 4-carboxamido derivatives of 1-(8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperazine to explore the SAR of of this series of FPT inhibitors is described. This result
Autor:
Alan K. Mallams, Doll Ronald J, Shiyong Wang, Jesse Wong, Walter R. Bishop, Ashit K. Ganguly, F. G. Njoroge, Donna Carr, Linda James, Bancha Vibulbhan, Taveras Arthur G, Z. Li, C. Nardo, I. King, James J. Kaminski, Joanne M. Petrin, Paul Kirschmeier, V. Girijavallabhan, Stacy W. Remiszewski, Ming Liu, Carmen S. Alvarez, Randall R. Rossman, Chin-Chung Lin, Mathew S. Bryant, Mark E. Snow, Joseph J. Catino
Publikováno v:
Bioorganic & Medicinal Chemistry. 5:93-99
Ras farnesylation by farnesyl protein transferase (FPT) is an intracellular event that facilitates the membrane association of the ras protein and is involved in the signal transduction process. FPT inhibition could be a novel, noncytotoxic method of
Autor:
Michael L. Gross, Ronald L. Cerny, Birendra N. Pramanik, Alan K. Mallams, Denise K. MacMillan
Publikováno v:
Journal of the American Society for Mass Spectrometry. 5:151-158
Molecular weights of macrolide antibiotics can be determined from either (M + H)+ or (M + Met)+, the latter desorbed from alkali metal salt-saturated matrices. The ion chemistry of macrolides, as determined by tandem mass spectrometry (MS/MS), is dif
Autor:
Stacy Remiszewski, W. R. Bishop, Ronald J. Maplewood Doll, Randall R. Rossman, J. Desai, C. J. Aki, Corey Strickland, J. Deskus, P. Kirschmeier, Robert Patton, Mathew S. Bryant, Ronald Wolin, D. F. Rane, Carmen S. Alvarez, James Wang, J. del Rosario, Y. Liu, F. G. Njoroge, John D. Kelly, Donna Carr, Amin A. Nomeir, P. Pinto, B. Vibulbhan, Cooper Alan B, Adriano Afonso, Ming Liu, Linda James, Michael Connolly, V. Girijavallabhan, Patricia C. Weber, Chao Jianping, A. K. Ganguly, Alan K. Mallams, Lynn Wang, Arthur G. Taveras
Publikováno v:
Anticancer Agents ISBN: 9780841237452
Anticancer Agents: Frontiers in Cancer Chemotherapy
Anticancer Agents: Frontiers in Cancer Chemotherapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4b7cd535d2226118db7c5197f319cee
https://doi.org/10.1021/bk-2001-0796.ch013
https://doi.org/10.1021/bk-2001-0796.ch013
Autor:
A.K. Ganguly, Piwinski John J, D. Cesarz, J. del Rosario, V. Girijavallabhan, Hung V. Le, William T. Windsor, J. Deskus, Margaret M. Albanese, Corey Strickland, Doll Ronald J, Randall R. Rossman, Patricia C. Weber, Bancha Vibulbhan, Zhen Wu, Taveras Arthur G, Stacy W. Remiszewski, F. G. Njoroge, Alan K. Mallams, Carmen S. Alvarez
Publikováno v:
Journal of medicinal chemistry. 42(12)
Crystallographic and thermodynamic studies of farnesyl protein transferase (FPT) complexed with novel tricyclic inhibitors provide insights into the observed SAR for this unique class of nonpeptidic FPT inhibitors. The crystallographic structures rev
Autor:
Matthew Bryant, Dell J, Ming Liu, Amin A. Nomeir, Bohdan Yaremko, Randall R. Rossman, Paul Kirschmeier, Doll Ronald J, Chin-Chung Lin, Walter A. Korfmacher, Joseph J. Catino, N. Prioli, M. Malkowski, Philip Lipari, Walter R. Bishop, V. Girijavallabhan, Z. Li, Alan K. Mallams, Jianping Chen, Suininhg Lee
Publikováno v:
Cancer chemotherapy and pharmacology. 43(1)
The products of the Ha-, Ki-, and N-ras proto-oncogenes comprise a family of 21 kDa guanine nucleotide-binding proteins which play a crucial role in growth factor signal transduction and in the control of cellular proliferation and differentiation. A
Autor:
Andrew T. McPhail, Kelly Joseph M, Joycelyn del Rosario, James Wang, Ronald Wolin, Arthur G. Taveras, Alan K. Mallams, Stacy Remiszewski, C.-C. Lin, W. Robert Bishop, and Viyyoor M. Girijavallabhan, P. Kirschmeier, Carmen S. Alvarez, J. Desai, Lynn Wang, Jeffrey Deskus, Cooper Alan B, Michael Connolly, Adriano Afonso, F. George Njoroge, P. Pinto, Y. Liu, Ming Liu, B. Vibulbhan, Robert Patton, Dinananth F. Rane, Amin A. Nomeir, Jesse Wong, Ronald J. Maplewood Doll, Randall R. Rossman, Mathew S. Bryant, A. K. Ganguly
Publikováno v:
Journal of medicinal chemistry. 41(24)
We have previously shown that appropriate modification of the benzocycloheptapyridine tricyclic ring system can provide potent farnesyl protein transferase (FPT) inhibitors with good cellular activity. Our laboratories have also established that inco
Autor:
Raymond Brambilla, Peter L. Bartner, Dena L. Boxler, Alan K. Mallams, James B. Morton, Paul Reichert, Ton That Thang, Gabor Lukacs, Satoshi Omura
Publikováno v:
Journal of the American Chemical Society. 100:663-666