Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Alan K. Howe"'
Autor:
Kathryn V. Svec, Alan K. Howe
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Cell migration requires establishment and maintenance of directional polarity, which in turn requires spatial heterogeneity in the regulation of protrusion, retraction, and adhesion. Thus, the signaling proteins that regulate these various structural
Externí odkaz:
https://doaj.org/article/44bf5d0096c945d8be6fea26b189e3a4
Autor:
Andrew J. McKenzie, Stephanie R. Hicks, Kathryn V. Svec, Hannah Naughton, Zöe L. Edmunds, Alan K. Howe
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-20 (2018)
Abstract There is growing appreciation of the importance of the mechanical properties of the tumor microenvironment on disease progression. However, the role of extracellular matrix (ECM) stiffness and cellular mechanotransduction in epithelial ovari
Externí odkaz:
https://doaj.org/article/e188616ed8974641a305dd3aa2218f57
Autor:
Bart O. Williams, Alan K. Howe, Merry Jo Oursler, Larry Pederson, Ming Ruan, Christine M Hachfeld, Rachel A Davey, Megan M. Weivoda, Yasuhiro Kobayashi, Sundeep Khosla, Jennifer J. Westendorf, Jeffrey D Zajac
Publikováno v:
Journal of Bone and Mineral Research. 34:1546-1548
Although there has been extensive characterization of the Wnt signaling pathway in the osteoblast lineage, the effects of Wnt proteins on the osteoclast lineage are less well studied. We found that osteoclast lineage cells express canonical Wnt recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df26116b7ec428ea047d420f3c16a4a4
https://doi.org/10.1002/jbmr.3740
https://doi.org/10.1002/jbmr.3740
Protein kinase A activity and anchoring are required for ovarian cancer cell migration and invasion.
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26552 (2011)
Epithelial ovarian cancer (EOC) is the deadliest of the gynecological malignancies, due in part to its clinically occult metastasis. Therefore, understanding the mechanisms governing EOC dissemination and invasion may provide new targets for antimeta
Externí odkaz:
https://doaj.org/article/6ad1b0fe16984ccdaf8a489ce763052b
Publikováno v:
J Vis Exp
Durotaxis is the process by which cells sense and respond to gradients of tension. In order to study this process in vitro, the stiffness of the substrate underlying a cell must be manipulated. While hydrogels with graded stiffness and long-term migr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6258a6dc8f8027e761a3acbe071596e7
https://doi.org/10.3791/59995
https://doi.org/10.3791/59995
Publikováno v:
Molecular Biology of the Cell
Mitochondria infiltrate leading edge lamellipodia, increasing local mitochondrial mass and relative ATP concentration. AMPK regulates infiltration of mitochondria into the leading edge of 2D lamellipodia and 3D invadopodia, coupling local metabolic s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23186f5889882b1c7d8ed53d85975779
https://doi.org/10.1091/mbc.e16-05-0286
https://doi.org/10.1091/mbc.e16-05-0286
Publikováno v:
Molecular Biology of the Cell
Dynamic subcellular regulation of Protein kinase A (PKA) activity is important for the motile behavior of many cell types, yet the mechanisms governing PKA activity during cell migration remain largely unknown. The motility of SKOV-3 epithelial ovari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e6f09df9fc31bcae75194f18c24933f
Autor:
Zöe L. Edmunds, Kathryn V Svec, Stephanie R. Hicks, Alan K. Howe, Andrew J. McKenzie, Hannah Naughton
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-20 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-20 (2018)
There is growing appreciation of the importance of the mechanical properties of the tumor microenvironment on disease progression. However, the role of extracellular matrix (ECM) stiffness and cellular mechanotransduction in epithelial ovarian cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::643d815a39debc24f76565990677967e
https://doi.org/10.1101/238311
https://doi.org/10.1101/238311
Autor:
Merry Jo Oursler, Ming Ruan, Jeffrey D Zajac, Megan M. Weivoda, Alan K. Howe, Larry Pederson, Jennifer J. Westendorf, Christine M Hachfeld, Bart O. Williams, Yasuhiro Kobayashi, Sundeep Khosla, Rachel A Davey
Publikováno v:
Journal of Bone and Mineral Research. 31:65-75
Although there has been extensive characterization of the Wnt signaling pathway in the osteoblast lineage, the effects of Wnt proteins on the osteoclast lineage are less well studied. We found that osteoclast lineage cells express canonical Wnt recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10fca5b3912efce6dd5121e9ef939585
https://doi.org/10.1002/jbmr.2599
https://doi.org/10.1002/jbmr.2599
Publikováno v:
Journal of Cellular Biochemistry. 114:1714-1719
The biomechanical behavior of connective tissue in response to stretching is generally attributed to the molecular composition and organization of its extracellular matrix. It also is becoming apparent that fibroblasts play an active role in regulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::083271fd37fe14b4bf0abffc2dc609f5
https://doi.org/10.1002/jcb.24521
https://doi.org/10.1002/jcb.24521