Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Alan John Pettman"'
Autor:
Joel M. Hawkins, Debbie Kraus, Susana Torres, Garry Scrivens, Alan John Pettman, Mark R. Taylor, Roman Szucs, Roland Brown
Publikováno v:
Organic Process Research & Development. 19:1596-1603
A new method for the fast and convenient synthesis of pharmaceutical oxidation products is described. Two oxidation products of fesoterodine were electrochemically synthesized, isolated, and characterized. The influence of synthetic operating paramet
Publikováno v:
RSC Adv.. 4:51845-51849
A heterogeneous copper catalyst, formed in situ, has been shown to dehydrocouple commercially available amine boranes whilst transferring hydrogen for the reduction of selected organic functional groups in an aqueous medium. The catalytic system has
Publikováno v:
Advanced Synthesis & Catalysis. 355:35-40
Promoted by iodide anion the rhodium complex dimer, [Cp*RhCl2]2, catalyzes efficiently the transfer hydrogenation of various quaternary pyridinium salts under mild conditions, affording not only piperidines but also 1,2,3,6-tetrahydropyridines in a h
Autor:
Alan John Pettman, Nieves Castro, Iain Robert Gladwell, Ian B. Moses, Natalie A. Morrison, Maninder S. Panesar, Nicholas Murray Thomson, Pieter D. de Koning
Publikováno v:
Organic Process Research & Development. 15:1256-1265
The development of a practical, scalable route to PF-00610355 (8) is described. In this convergent approach, amine 9 is coupled to protected bromohydrin 1 to give the doubly protected intermediate 26. TBS-Deprotection of 26 affords the benzyl protect
Autor:
Iain Robert Gladwell, Ian B. Moses, Nicholas Murray Thomson, Maninder S. Panesar, Alan John Pettman, Pieter D. de Koning
Publikováno v:
Organic Process Research & Development. 15:1247-1255
The initial route used to prepare PF-00610355 (8) for early clinical development is described. Through careful choice of solvent, an efficient, telescoped route to carboxylic acid 23 was developed, affording this late-stage intermediate in 80% yield
Autor:
Yogesh A. Sabnis, Alan John Pettman, Bernard Joseph Banks, Neil Feeder, Robert Crook, Graham Lunn
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:4608-4611
In looking for a novel achiral μ opioid receptor antagonist for the treatment of pruritus, we designed and synthesised azabicyclo[3.1.0]hexane compounds as a new class of opioid ligand. During optimisation, an addition of a single methyl resulted in
Autor:
Andrew J. Bibb, Petar I. Nikiforov, Stuart Field, Steven J. Fussell, Olivier Dirat, Mason Clive Philip, Alan John Pettman, Colin M. Burns, Green Stuart, Ian B. Moses, Jinu S. Mathew, Graham Checksfield, Barry Richard Dillon, Flavien Susanne, Suju Mathew
Publikováno v:
Organic Process Research & Development. 15:1010-1017
We report the discovery and optimization of an amine-promoted Friedel–Crafts alkylation of cinnamaldehyde with 4-hydroxymethyl phenol. This reaction has been used successfully on commercial scale (200 kg) in the context of the manufacture of fesote
Autor:
Alan John Pettman, Daniel R. Yazbeck, Maninder S. Panesar, Nicholas Murray Thomson, Ian B. Moses, Iain Robert Gladwell, Pieter D. de Koning, Natalie A. Morrison
Publikováno v:
Organic Process Research & Development. 15:871-875
An efficient process to ethyl [3-(2-amino-2-methylpropyl)phenyl]acetate 6 has been developed. Key steps include a novel enzymatic desymmetrization of diester 2 and a Ritter reaction between alcohol...
Autor:
Alan John Pettman, Suju Mathew, Georges Assaf, Doug Critcher, Gemma Cansell, Stewart T. Hayes, Stuart Field
Publikováno v:
Tetrahedron Letters. 51:5048-5051
We report our results on the construction of a morpholine ring system from the corresponding epoxide and amino alcohol. From this study, we were able to convert a previous four-step synthesis into a more efficient two-step process.
Publikováno v:
Angewandte Chemie International Edition. 49:7548-7552
Reductive amination of a wide variety of aromatic and aliphatic ketones and aldehydes with primary and secondary amines proceeds smoothly in the presence of a novel cyclometalated Ir catalyst.