Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Alan J. Warren"'
Autor:
Janeska J. de Jonge, Andreas Graw, Vasileios Kargas, Christopher Batters, Antonino F. Montanarella, Tom O’Loughlin, Chloe Johnson, Susan D. Arden, Alan J. Warren, Michael A. Geeves, John Kendrick-Jones, Nathan R. Zaccai, Markus Kröss, Claudia Veigel, Folma Buss
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Myosin motors perform many fundamental functions in eukaryotic cells by providing force generation, transport or tethering capacity. Motor activity control within the cell involves on/off switches, however, few examples are known of how myos
Externí odkaz:
https://doaj.org/article/7154c67ddb744e59a37c38b04052c87d
Autor:
Heather E. Machado, Nina F. Øbro, Nicholas Williams, Shengjiang Tan, Ahmed Z. Boukerrou, Megan Davies, Miriam Belmonte, Emily Mitchell, E. Joanna Baxter, Nicole Mende, Anna Clay, Philip Ancliff, Jutta Köglmeier, Sally B. Killick, Austin Kulasekararaj, Stefan Meyer, Elisa Laurenti, Peter J. Campbell, David G. Kent, Jyoti Nangalia, Alan J. Warren
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Clonal tracking of cells using somatic mutations permits exploration of clonal dynamics in human disease. Here, we perform whole genome sequencing of 323 haematopoietic colonies from 10 individuals with the inherited ribosomopathy Shwachman-
Externí odkaz:
https://doaj.org/article/83d4535580c848179ab239f1596e4673
Autor:
Jacob Gordon, Fleur L. Chapus, Elizabeth G. Viverette, Jason G. Williams, Leesa J. Deterding, Juno M. Krahn, Mario J. Borgnia, Joseph Rodriguez, Alan J. Warren, Robin E. Stanley
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
PELP1 is a large scaffolding protein implicated in many cellular activities, including ribosome assembly as part of the Rix1 complex, comprising PELP1, WDR18, TEX10 and other components. Here, authors present the cryo-EM structure of PELP1 in complex
Externí odkaz:
https://doaj.org/article/7a28ba5ed69749b48501c3dc0b091105
Autor:
Francesca Fioredda, Julia Skokowa, Hannah Tamary, Michail Spanoudakis, Piero Farruggia, Antonio Almeida, Daniela Guardo, Petter Höglund, Peter E. Newburger, Jan Palmblad, Ivo P. Touw, Cornelia Zeidler, Alan J. Warren, David C. Dale, Karl Welte, Carlo Dufour, Helen A. Papadaki
Publikováno v:
HemaSphere, Vol 7, Iss 4, p e872 (2023)
Neutropenia, as an isolated blood cell deficiency, is a feature of a wide spectrum of acquired or congenital, benign or premalignant disorders with a predisposition to develop myelodysplastic neoplasms/acute myeloid leukemia that may arise at any age
Externí odkaz:
https://doaj.org/article/8d24a5729708435dac85ec75944ea448
Autor:
Pekka Jaako, Alexandre Faille, Shengjiang Tan, Chi C. Wong, Norberto Escudero-Urquijo, Pablo Castro-Hartmann, Penny Wright, Christine Hilcenko, David J. Adams, Alan J. Warren
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Jaako et al. discover a conserved tier of translational control that dynamically couples ribosome assembly and recycling. This mechanism is corrupted in an inherited bone marrow failure disorder associated with an increased risk of blood cancer.
Externí odkaz:
https://doaj.org/article/453b7a70084349bea9b8597caaa6ef1f
Autor:
Pedro Rebelo-Guiomar, Simone Pellegrino, Kyle C. Dent, Aldema Sas-Chen, Leonor Miller-Fleming, Caterina Garone, Lindsey Van Haute, Jack F. Rogan, Adam Dinan, Andrew E. Firth, Byron Andrews, Alexander J. Whitworth, Schraga Schwartz, Alan J. Warren, Michal Minczuk
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Rebelo-Guiomar et al. unveil late stage assembly intermediates of the human mitochondrial ribosome by inactivating the methyltransferase MRM2 in cells. Absence of MRM2 impairs organismal homeostasis, while its catalytic activity is dispensable for mi
Externí odkaz:
https://doaj.org/article/b26a6648dba14e5181a35583967acaa7
Autor:
Shengjiang Tan, Laëtitia Kermasson, Christine Hilcenko, Vasileios Kargas, David Traynor, Ahmed Z. Boukerrou, Norberto Escudero-Urquijo, Alexandre Faille, Alexis Bertrand, Maxim Rossmann, Beatriz Goyenechea, Li Jin, Jonathan Moreil, Olivier Alibeu, Blandine Beaupain, Christine Bôle-Feysot, Stefano Fumagalli, Sophie Kaltenbach, Jean-Alain Martignoles, Cécile Masson, Patrick Nitschké, Mélanie Parisot, Aurore Pouliet, Isabelle Radford-Weiss, Frédéric Tores, Jean-Pierre de Villartay, Mohammed Zarhrate, Ai Ling Koh, Kong Boo Phua, Bruno Reversade, Peter J. Bond, Christine Bellanné-Chantelot, Isabelle Callebaut, François Delhommeau, Jean Donadieu, Alan J. Warren, Patrick Revy
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Shwachman-Diamond syndrome (SDS) is a leukemia predisposition disorder that is caused by defective release of eIF6 during ribosome assembly. Here the authors show that acquired somatic EIF6 mutations are frequent in the hematopoietic cells from indiv
Externí odkaz:
https://doaj.org/article/a48dd70c00914ebb83beed70d65306d7
Autor:
Sandra Cantilena, Luca Gasparoli, Deepali Pal, Olaf Heidenreich, Jan‐Henning Klusmann, Joost H. A. Martens, Alexandre Faille, Alan J. Warren, Mawar Karsa, Ruby Pandher, Klaartje Somers, Owen Williams, Jasper de Boer
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 6, Pp n/a-n/a (2022)
Abstract Background Improving the poor prognosis of infant leukaemias remains an unmet clinical need. This disease is a prototypical fusion oncoprotein‐driven paediatric cancer, with MLL (KMT2A)‐fusions present in most cases. Direct targeting of
Externí odkaz:
https://doaj.org/article/1c1567bc09014df8bcc740417102afeb
Autor:
Shengjiang Tan, Laëtitia Kermasson, Christine Hilcenko, Vasileios Kargas, David Traynor, Ahmed Z. Boukerrou, Norberto Escudero-Urquijo, Alexandre Faille, Alexis Bertrand, Maxim Rossmann, Beatriz Goyenechea, Li Jin, Jonathan Moreil, Olivier Alibeu, Blandine Beaupain, Christine Bôle-Feysot, Stefano Fumagalli, Sophie Kaltenbach, Jean-Alain Martignoles, Cécile Masson, Patrick Nitschké, Mélanie Parisot, Aurore Pouliet, Isabelle Radford-Weiss, Frédéric Tores, Jean-Pierre de Villartay, Mohammed Zarhrate, Ai Ling Koh, Kong Boo Phua, Bruno Reversade, Peter J. Bond, Christine Bellanné-Chantelot, Isabelle Callebaut, François Delhommeau, Jean Donadieu, Alan J. Warren, Patrick Revy
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/8657ae5e714d4945aeb05193ccfe9904
Autor:
Alice Costantini, Jessica J. Alm, Francesca Tonelli, Helena Valta, Céline Huber, Anh N. Tran, Valentina Daponte, Nadi Kirova, Yong-Uk Kwon, Jung Yun Bae, Woo Yeong Chung, Shengjiang Tan, Yves Sznajer, Gen Nishimura, Tuomas Näreoja, Alan J. Warren, Valérie Cormier-Daire, Ok-Hwa Kim, Antonella Forlino, Tae-Joon Cho, Outi Mäkitie
Publikováno v:
Bone Reports, Vol 13, Iss , Pp 100647- (2020)
Externí odkaz:
https://doaj.org/article/82391d474b4843248d0f88dd26afa5d1