Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Alan J. Lueke"'
Autor:
Leslie J. Donato, Duane Burton, Michael Camilleri, Irene Busciglio, Alan J. Lueke, Priya Vijayvargiya
Publikováno v:
Alimentary Pharmacology & Therapeutics. 49:744-758
Background Biomarkers in irritable bowel syndrome (IBS) may guide targeted therapy in this multifactorial disease. It has been suggested that 75% accuracy and cost Aim To identify differences in faecal bile acids, faecal fat and fasting serum C4 (7a-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19b2e85fe3fd33a8fcbb692951603778
https://doi.org/10.1111/apt.15106
https://doi.org/10.1111/apt.15106
Autor:
Irene Busciglio, Priya Vijayvargiya, Alan J. Lueke, Michael Camilleri, Duane Burton, Leslie J. Donato
Publikováno v:
Clinical Gastroenterology and Hepatology. 16:522-527
Background & Aims Short-term administration of delayed-release chenodeoxycholic acid to patients with irritable bowel syndrome with constipation (IBS-C) accelerates colonic transit and reduces symptoms. A preliminary study has shown that patients wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fc997ecdb9efc5b240a65fdca970d08
https://doi.org/10.1016/j.cgh.2017.06.039
https://doi.org/10.1016/j.cgh.2017.06.039
Autor:
Amber V. Gray, Jeffrey W. Meeusen, Joseph H. Butterfield, Amy K. Saenger, Leslie J. Donato, Alan J. Lueke
Publikováno v:
Clinical Biochemistry. 49:979-982
Systemic mastocytosis (SM) is a disorder characterized by the excessive accumulation of clonally derived mast cells in various tissues. When triggered, mast cells release large amounts of histamine, prostaglandins and leukotrienes. Leukotriene E4 (LT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8e71e2d0d011246d127145c3763c9e3
https://doi.org/10.1016/j.clinbiochem.2016.02.007
https://doi.org/10.1016/j.clinbiochem.2016.02.007
Autor:
William Rossini, Alan J. Lueke, Ann Taylor, Teresa Miceli, Leslie J. Donato, Michael Camilleri, Duane Burton, William J. Hogan, Wilson I. Gonsalves, Priya Vijayvargiya
Publikováno v:
Bone marrow transplantation. 54(11)
Autologous stem cell transplant (ASCT) for multiple myeloma (MM) is associated with diarrhea during the peri-transplant period. We aimed to appraise mechanisms of peri-ASCT diarrhea in a prospective, longitudinal study of patients with MM. We compare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd3f11ff771c64af13d5cda2679cde1e
https://pubmed.ncbi.nlm.nih.gov/31148601
https://pubmed.ncbi.nlm.nih.gov/31148601
Autor:
Amy Boldingh, Andres Acosta, Amber V. Gray, Alan J. Lueke, Roy B. Dyer, Leslie J. Donato, Michael Camilleri, Alan R. Zinsmeister, Irene Busciglio
Publikováno v:
Alimentary Pharmacology & Therapeutics. 41:438-448
Background About one-third of patients with IBS-diarrhea (IBS-D) have evidence of increased bile acid (BA) synthesis or excretion.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3775da874655a82d778eaba7f4d635c3
https://doi.org/10.1111/apt.13065
https://doi.org/10.1111/apt.13065
Autor:
Paula Carlson, Michael Camilleri, Ibironke Oduyebo, Stephen Joseph Rossi, Duane Burton, Michael Ryks, Disha Khemani, Alan J. Lueke, Irene Busciglio, Sara Linker Nord, Leslie J. Donato, Alfred D. Nelson, Deborah Rhoten, Kathline H. Kim, Alan R. Zinsmeister
Publikováno v:
The American journal of gastroenterology. 113(5)
NGM282 is an analog of fibroblast growth factor 19 (FGF19), a potent inhibitor of bile acid (BA) synthesis in animals and humans. In phase 2 trials in type 2 diabetes and primary biliary cholangitis, NGM282 was associated with dose-related abdominal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e831d38623f2decdcc03d38abbd1200c
https://pubmed.ncbi.nlm.nih.gov/29717197
https://pubmed.ncbi.nlm.nih.gov/29717197
Publikováno v:
Clinical biochemistry. 52
Background Imbalance of bile acids (BA) homeostasis in the gastrointestinal tract can lead to chronic diarrhea or constipation when BA in the colon are in excess or low, respectively. Since both disturbances of bowel function can result from other et
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d207209d956ec35db106fde81ad2097a
https://pubmed.ncbi.nlm.nih.gov/29051033
https://pubmed.ncbi.nlm.nih.gov/29051033
Autor:
Alan J. Lueke, Leslie J. Donato, Jessica O'Neill, Irene Busciglio, Michael Camilleri, Priya Vijayvargiya, Duane Burton, Paula Carlson
Publikováno v:
Alimentary pharmacologytherapeutics. 46(6)
SummaryBackground The serum biomarkers, elevated 7αC4 (C4) and decreased FGF19, have been proposed as screening tests for bile acid diarrhoea. Aim To analyse prevalence, specificity and reproducibility of fasting C4 and FGF19 in identifying bile aci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d00291b73c26f1d212258b68be445c5a
https://pubmed.ncbi.nlm.nih.gov/28880443
https://pubmed.ncbi.nlm.nih.gov/28880443
Publikováno v:
Clinical Chemistry. 60:1519-1523
BACKGROUND Aggressive LDL cholesterol (LDL-C)-lowering strategies are recommended for primary and secondary prevention of cardiovascular events. A newly derived equation for LDL-C estimation was recently published that addressed limitations in the co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2657423540693071aa18356a7e510942
https://doi.org/10.1373/clinchem.2014.227710
https://doi.org/10.1373/clinchem.2014.227710
Autor:
Irene Busciglio, Deborah Rhoten, Alan J. Lueke, Andrea Shin, Andres Acosta, Alan R. Zinsmeister, Paula Carlson, Michael Camilleri, Michael Ryks, Jesse Lamsam, Duane Burton, Leslie J. Donato
Publikováno v:
American Journal of Gastroenterology. 109:1621-1630
OBJECTIVES: Approximately 25% of patients with irritable bowel syndrome-diarrhea (IBS-D) have increased total fecal bile acids (BA) and serum C4 (surrogate for BA synthesis). BA synthesis-related genes (KLB and FGFR4) are associated with colonic tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00acc48447127c1885542386d1b27ca7
https://doi.org/10.1038/ajg.2014.215
https://doi.org/10.1038/ajg.2014.215