Zobrazeno 1 - 10
of 196
pro vyhledávání: '"Alan J. Korman"'
Autor:
Ornella Pagliano, Robert M. Morrison, Joe-Marc Chauvin, Hridesh Banerjee, Diwakar Davar, Quanquan Ding, Tokiyoshi Tanegashima, Wentao Gao, Saranya R. Chakka, Richelle DeBlasio, Ava Lowin, Kevin Kara, Mignane Ka, Bochra Zidi, Rada Amin, Itay Raphael, Shuowen Zhang, Simon C. Watkins, Cindy Sander, John M. Kirkwood, Marcus Bosenberg, Ana C. Anderson, Vijay K. Kuchroo, Lawrence P. Kane, Alan J. Korman, Arvind Rajpal, Sean M. West, Minhua Han, Christine Bee, Xiaodi Deng, Xiao Min Schebye, Pavel Strop, Hassane M. Zarour
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 9 (2022)
T cell immunoglobulin mucin domain-containing protein 3 (Tim-3) negatively regulates innate and adaptive immunity in cancer. To identify the mechanisms of Tim-3 in cancer immunity, we evaluated the effects of Tim-3 blockade in human and mouse melanom
Externí odkaz:
https://doaj.org/article/00341078d5a94f57ba93043742d00efb
Blood–brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy
Autor:
Anna Galstyan, Janet L. Markman, Ekaterina S. Shatalova, Antonella Chiechi, Alan J. Korman, Rameshwar Patil, Dmytro Klymyshyn, Warren G. Tourtellotte, Liron L. Israel, Oliver Braubach, Vladimir A. Ljubimov, Leila A. Mashouf, Arshia Ramesh, Zachary B. Grodzinski, Manuel L. Penichet, Keith L. Black, Eggehard Holler, Tao Sun, Hui Ding, Alexander V. Ljubimov, Julia Y. Ljubimova
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Abstract Brain glioma treatment with checkpoint inhibitor antibodies to cytotoxic T-lymphocyte-associated antigen 4 (a-CTLA-4) and programmed cell death-1 (a-PD-1) was largely unsuccessful due to their inability to cross blood–brain barrier (BBB).
Externí odkaz:
https://doaj.org/article/094da27c385c4fb5be871715c40d5f4e
Autor:
Anna Galstyan, Janet L. Markman, Ekaterina S. Shatalova, Antonella Chiechi, Alan J. Korman, Rameshwar Patil, Dmytro Klymyshyn, Warren G. Tourtellotte, Liron L. Israel, Oliver Braubach, Vladimir A. Ljubimov, Leila A. Mashouf, Arshia Ramesh, Zachary B. Grodzinski, Manuel L. Penichet, Keith L. Black, Eggehard Holler, Tao Sun, Hui Ding, Alexander V. Ljubimov, Julia Y. Ljubimova
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-20129-9
Externí odkaz:
https://doaj.org/article/c5eafb16680642ac8a00a3c8aa9d916a
Autor:
Erika J. Crosby, Junping Wei, Xiao Yi Yang, Gangjun Lei, Tao Wang, Cong-Xiao Liu, Pankaj Agarwal, Alan J. Korman, Michael A. Morse, Kenneth Gouin, Simon R. V. Knott, H. Kim Lyerly, Zachary C. Hartman
Publikováno v:
OncoImmunology, Vol 7, Iss 5 (2018)
Triple-negative breast cancer (TNBC) is an aggressive and molecularly diverse breast cancer subtype typified by the presence of p53 mutations (∼80%), elevated immune gene signatures and neoantigen expression, as well as the presence of tumor infilt
Externí odkaz:
https://doaj.org/article/c1f12874871c4c10bce8a2bcabe257fc
Autor:
Katherine E. Lewis, Mark J. Selby, Gregg Masters, Jose Valle, Gennaro Dito, Wendy R. Curtis, Richard Garcia, Kathy A. Mink, Kimberly S. Waggie, Matthew S. Holdren, Joseph F. Grosso, Alan J. Korman, Maria Jure-Kunkel, Stacey R. Dillon
Publikováno v:
OncoImmunology, Vol 7, Iss 1 (2018)
Recent advances in cancer treatment with checkpoint blockade of receptors such as CTLA-4 and PD-1 have demonstrated that combinations of agents with complementary immunomodulatory effects have the potential to enhance antitumor activity as compared t
Externí odkaz:
https://doaj.org/article/54e3b8070e6e4ea1b4254c709405e4a3
Autor:
Kent Thudium, Mark Selby, Julie A. Zorn, Gregory Rak, Xi-Tao Wang, Roderick Todd Bunch, Jason M. Hogan, Pavel Strop, Alan J. Korman
Publikováno v:
Cancer Immunology Research. 10:1175-1189
Novel therapeutic approaches combining immune checkpoint inhibitors are needed to improve clinical outcomes for patients with cancer. Lymphocyte-activation gene 3 (LAG-3) is an immune checkpoint molecule that inhibits T-cell activity and antitumor im
Autor:
Douglas Hanahan, Melody A. Swartz, Lisa M. Coussens, Alan J. Korman, Wesley Horton, Nadine Zangger, Dhaarini Murugan, Mélanie Tichet, Stephan Wullschleger, Gabriele Galliverti
Cancers induced by human papillomaviruses (HPV) should be responsive to immunotherapy by virtue of expressing the immunogenic oncoproteins E6/E7. However, advanced forms of cervical cancer, driven by HPV, are poorly responsive to immune response–en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1820704b78feea6b9c16767badac9930
https://doi.org/10.1158/2326-6066.c.6550152.v1
https://doi.org/10.1158/2326-6066.c.6550152.v1
Autor:
Alan J. Korman, Pavel Strop, Jason M. Hogan, Roderick Todd Bunch, Xi-Tao Wang, Gregory Rak, Julie A. Zorn, Mark Selby, Kent Thudium
Novel therapeutic approaches combining immune-checkpoint inhibitors are needed to improve clinical outcomes for patients with cancer. Lymphocyte-activation gene 3 (LAG-3) is an immune-checkpoint molecule that inhibits T-cell activity and antitumor im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61f873646c4378fa6cbb3fc2c62d7017
https://doi.org/10.1158/2326-6066.c.6551000.v1
https://doi.org/10.1158/2326-6066.c.6551000.v1
Autor:
Douglas Hanahan, Melody A. Swartz, Lisa M. Coussens, Alan J. Korman, Wesley Horton, Nadine Zangger, Dhaarini Murugan, Mélanie Tichet, Stephan Wullschleger, Gabriele Galliverti
Supplemental Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80d5b080828c601c05bd0b680610bade
https://doi.org/10.1158/2326-6066.22543143
https://doi.org/10.1158/2326-6066.22543143
Autor:
Alan J. Korman, Pavel Strop, Jason M. Hogan, Roderick Todd Bunch, Xi-Tao Wang, Gregory Rak, Julie A. Zorn, Mark Selby, Kent Thudium
Supplementary Data from Preclinical Characterization of Relatlimab, a Human LAG-3–Blocking Antibody, Alone or in Combination with Nivolumab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5105aa7f014ffe63c49424bcb78d4df9
https://doi.org/10.1158/2326-6066.22545668
https://doi.org/10.1158/2326-6066.22545668