Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Alan J. Kennan"'
Autor:
Kaylee M. Clark, Melissa S. Schenkel, Trey W. Pittman, Isabelle C. Samper, Loran B. R. Anderson, Wisarut Khamcharoen, Suad Elmegerhi, Rushika Perera, Weena Siangproh, Alan J. Kennan, Brian J. Geiss, David S. Dandy, Charles S. Henry
Publikováno v:
ACS measurement science au. 2(6)
The COVID-19 pandemic focused attention on a pressing need for fast, accurate, and low-cost diagnostic tests. This work presents an electrochemical capillary driven immunoassay (eCaDI) developed to detect SARS-CoV-2 nucleocapsid (N) protein. The low-
Autor:
Rachel L. Tennyson, Susanne N. Walker, Brian R. McNaughton, Reuben S. Harris, Terumasa Ikeda, Alan J. Kennan
Publikováno v:
ChemBioChem. 17:1945-1950
The size, functional group diversity and three-dimensional structure of proteins often allow these biomolecules to bind disease-relevant structures that challenge or evade small-molecule discovery. Additionally, folded proteins are often much more st
Autor:
Maria L. Diss, Alan J. Kennan
Publikováno v:
The Journal of Organic Chemistry. 73:9752-9755
We report several coiled coil heterotrimers with varying core residue buried polar groups, all with T(m) values43 degrees C. Introduction of new synthetic side chain structures, including some terminating in monosubstituted ureas, diversifies the poo
Autor:
Alan J. Kennan, Maria L. Diss
Publikováno v:
Organic Letters. 10:3797-3800
We describe simultaneous formation of three distinct heterodimeric coiled coils from a mixture of six different peptides. The choice among electrostatically viable complexes is governed by alignment of buried core residues, including a fundamentally
Autor:
Alan J. Kennan, Nathan A. Schnarr
Publikováno v:
Organic Letters. 7:395-398
[structure: see text] The design of antiparallel coiled-coil heterotrimers with singly mismatched electrostatic interfaces is reported. The new complexes exhibit expected properties for well-formed coiled-coils and have stabilities comparable to thos
Autor:
Philip Travisano, Alan J. Kennan
Publikováno v:
Organic Letters. 6:4219-4222
Coiled-coil trimers of differing stability have been designed by judicious choice of hydrophobic core side chain identity. Steric matching of two alanines with one large side chain at three core positions affords stable heterotrimers. Use of either c
Autor:
Nathan A. Schnarr, Alan J. Kennan
Publikováno v:
Journal of the American Chemical Society. 126:14447-14451
The design of an antiparallel coiled-coil 1:1:1 heterotrimer is described. Control of strand orientation results from proper alignment of sterically matched hydrophobic core side chains. Matched core layers position one cyclohexylalanine side chain a
Autor:
Nathan A. Schnarr, Alan J. Kennan
Publikováno v:
Journal of the American Chemical Society. 125:13046-13051
The capacity for sequential and specific exchange of single peptides from coiled-coil heterotrimers is investigated. Dual hydrophobic-hydrophilic interface systems permit iterative cycles of pH-triggered strand exchange that can specifically replace
Autor:
Alan J. Kennan, Nathan A. Schnarr
Publikováno v:
Journal of the American Chemical Society. 125:667-671
Designed coiled-coil heterotrimers are described whose assembly is governed by both hydrophobic and hydrophilic forces. Sterically matched hydrophobic core side-chain packing of alanine and cyclohexylalanine has been shown to promote formation of a 1
Publikováno v:
Nature. 389:706-709
The preparation of synthetic molecules showing the remarkable efficiencies characteristic of natural biopolymer catalysts remains a formidable challenge for chemical biology. Although significant advances have been made in the understanding of protei